SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pe6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 4pe6 PUTATIVE ABC
TRANSPORTER
(Thermobispora
bispora) 		3 / 3 TRP A 328
VAL A 286
TRP A 340
 None
 1.12A 1c4dA-4pe6A:
undetectable
1c4dB-4pe6A:
undetectable		 1c4dA-4pe6A:
8.28
1c4dB-4pe6A:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 4pe6 PUTATIVE ABC
TRANSPORTER
(Thermobispora
bispora) 		3 / 3 ARG A 182
TYR A 194
LYS A 198
 None
 0.97A 1uujB-4pe6A:
undetectable		 1uujB-4pe6A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4pe6 PUTATIVE ABC
TRANSPORTER
(Thermobispora
bispora) 		5 / 12 ALA A 238
ILE A 240
VAL A 284
ALA A 285
LEU A 319
 None
 1.12A 2h42B-4pe6A:
undetectable		 2h42B-4pe6A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 4pe6 PUTATIVE ABC
TRANSPORTER
(Thermobispora
bispora) 		5 / 9 PHE A 264
ALA A 270
TYR A 273
ALA A 249
GLY A 247
 None
 1.25A 2v7bA-4pe6A:
3.5		 2v7bA-4pe6A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 4pe6 PUTATIVE ABC
TRANSPORTER
(Thermobispora
bispora) 		5 / 9 PHE A 264
ALA A 270
TYR A 273
ALA A 249
GLY A 247
 None
 1.27A 2v7bB-4pe6A:
3.6		 2v7bB-4pe6A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 4pe6 PUTATIVE ABC
TRANSPORTER
(Thermobispora
bispora) 		4 / 8 ILE A 179
PHE A 252
ALA A 249
VAL A 181
 None
 0.87A 3me6B-4pe6A:
undetectable		 3me6B-4pe6A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4pe6 PUTATIVE ABC
TRANSPORTER
(Thermobispora
bispora) 		5 / 12 GLY A 241
ALA A 164
THR A 197
PHE A 264
VAL A 239
 None
 1.06A 3nvkI-4pe6A:
3.9		 3nvkI-4pe6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4pe6 PUTATIVE ABC
TRANSPORTER
(Thermobispora
bispora) 		4 / 7 PRO A 260
ILE A 259
GLY A 245
SER A 283
 None
 0.99A 4a3uB-4pe6A:
undetectable		 4a3uB-4pe6A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4pe6 PUTATIVE ABC
TRANSPORTER
(Thermobispora
bispora) 		4 / 7 GLY A 219
GLU A 265
ALA A 270
ASP A 335
 None
 0.96A 5mvsA-4pe6A:
2.4		 5mvsA-4pe6A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4pe6 PUTATIVE ABC
TRANSPORTER
(Thermobispora
bispora) 		4 / 8 GLY A 219
GLU A 265
ALA A 270
ASP A 335
 None
 0.95A 5mvsB-4pe6A:
2.2		 5mvsB-4pe6A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4pe6 PUTATIVE ABC
TRANSPORTER
(Thermobispora
bispora) 		4 / 8 GLY A 219
LYS A 224
ALA A 225
ASN A  59
 None
None
None
LTH  A 401 (-3.2A)
 0.88A 5mvsB-4pe6A:
2.2		 5mvsB-4pe6A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 4pe6 PUTATIVE ABC
TRANSPORTER
(Thermobispora
bispora) 		5 / 10 GLU A 265
GLY A 219
GLY A 247
ALA A 222
GLY A 243
 None
 1.11A 6e5zA-4pe6A:
5.6		 6e5zA-4pe6A:
20.64