SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pel'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA2_0
(ACTINOMYCIN D)		 4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens;
Kluyvera
cryocrescens) 		4 / 4 THR A 189
PRO B 244
THR A 188
PRO B 227
 None
 1.24A 1a7yA-4pelA:
undetectable
1a7yC-4pelA:
undetectable		 1a7yA-4pelA:
4.51
1a7yC-4pelA:
4.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens;
Kluyvera
cryocrescens) 		6 / 7 MET A 142
PHE A 146
PHE B  24
SER B  67
ALA B  69
ILE B 177
 None
 0.84A 1fxhA-4pelA:
25.6
1fxhB-4pelA:
undetectable		 1fxhA-4pelA:
72.34
1fxhB-4pelA:
17.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens;
Kluyvera
cryocrescens) 		5 / 7 MET A 142
SER A 149
PHE B  24
ALA B  69
PHE B  71
 None
 0.54A 1fxvA-4pelA:
25.6
1fxvB-4pelA:
undetectable		 1fxvA-4pelA:
72.34
1fxvB-4pelA:
17.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens;
Kluyvera
cryocrescens) 		6 / 8 MET A 142
SER A 149
PHE B  24
SER B  67
ALA B  69
ILE B 177
 None
 0.54A 1gm7A-4pelA:
25.6
1gm7B-4pelA:
undetectable		 1gm7A-4pelA:
72.34
1gm7B-4pelA:
17.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens;
Kluyvera
cryocrescens) 		6 / 8 MET A 142
SER A 149
SER B  67
ALA B  69
PHE B  71
ILE B 177
 None
 0.48A 1gm7A-4pelA:
25.6
1gm7B-4pelA:
undetectable		 1gm7A-4pelA:
72.34
1gm7B-4pelA:
17.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens;
Kluyvera
cryocrescens) 		5 / 7 MET A 142
PRO B  22
TYR B  31
SER B  67
ALA B  69
 None
 0.61A 1k5qA-4pelA:
25.6
1k5qB-4pelA:
undetectable		 1k5qA-4pelA:
76.13
1k5qB-4pelA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		4 / 5 GLY B 343
GLN B 341
VAL B 442
SER B 325
 None
 1.31A 1p6kB-4pelB:
undetectable		 1p6kB-4pelB:
22.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens;
Kluyvera
cryocrescens) 		6 / 8 MET A 142
PHE B  24
SER B  67
ALA B  69
ILE B 177
ASN B 241
 None
 0.56A 1pnlA-4pelA:
25.1
1pnlB-4pelA:
undetectable		 1pnlA-4pelA:
72.34
1pnlB-4pelA:
17.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens;
Kluyvera
cryocrescens) 		4 / 8 PHE A 146
PHE B  24
SER B  67
ILE B 177
 None
 0.87A 1pnlA-4pelA:
25.1
1pnlB-4pelA:
undetectable		 1pnlA-4pelA:
72.34
1pnlB-4pelA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens;
Kluyvera
cryocrescens) 		5 / 12 GLY B 194
ALA B 171
SER A 147
PRO B 197
ALA B 142
 None
 1.15A 1sg9C-4pelB:
2.2		 1sg9C-4pelB:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_O_CHDO3085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 11 PHE B 531
GLY B 532
MET B 485
GLU B 482
THR B 481
 None
 1.21A 1v54G-4pelB:
undetectable
1v54N-4pelB:
undetectable
1v54O-4pelB:
undetectable		 1v54G-4pelB:
9.81
1v54N-4pelB:
21.29
1v54O-4pelB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_O_CHDO3085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 11 PHE B 531
GLY B 532
MET B 485
GLU B 482
THR B 481
 None
 1.19A 1v55G-4pelB:
undetectable
1v55N-4pelB:
undetectable
1v55O-4pelB:
undetectable		 1v55G-4pelB:
9.81
1v55N-4pelB:
21.29
1v55O-4pelB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 10 TYR B 196
LEU B 175
ILE B 177
ALA B 250
LEU B 253
 None
 1.13A 1xp0A-4pelB:
undetectable		 1xp0A-4pelB:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		4 / 4 LEU B 296
PRO B 448
ILE B 346
LEU B 347
 None
 1.08A 1ya4C-4pelB:
undetectable		 1ya4C-4pelB:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		4 / 5 GLY B 343
GLN B 341
VAL B 442
SER B 325
 None
 1.32A 1zzuB-4pelB:
undetectable		 1zzuB-4pelB:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens;
Kluyvera
cryocrescens) 		5 / 12 GLU B 398
GLY B 259
ASP B 262
ASN A 183
ALA B 250
 None
 1.18A 2bm9B-4pelB:
undetectable		 2bm9B-4pelB:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 11 PHE B 531
GLY B 532
MET B 485
GLU B 482
THR B 481
 None
 1.23A 2dyrG-4pelB:
undetectable
2dyrN-4pelB:
undetectable
2dyrO-4pelB:
undetectable		 2dyrG-4pelB:
9.81
2dyrN-4pelB:
21.29
2dyrO-4pelB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 11 PHE B 531
GLY B 532
MET B 485
GLU B 482
THR B 481
 None
 1.19A 2eijG-4pelB:
undetectable
2eijN-4pelB:
undetectable
2eijO-4pelB:
undetectable		 2eijG-4pelB:
9.81
2eijN-4pelB:
21.29
2eijO-4pelB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 11 PHE B 531
GLY B 532
MET B 485
GLU B 482
THR B 481
 None
 1.20A 2eilG-4pelB:
undetectable
2eilN-4pelB:
undetectable
2eilO-4pelB:
undetectable		 2eilG-4pelB:
9.81
2eilN-4pelB:
21.29
2eilO-4pelB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_B_ANWB99_0
(PROTEIN S100-A13)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		4 / 8 ALA B  84
THR B 131
THR B 133
LYS B  81
 None
 1.16A 2kotB-4pelB:
undetectable		 2kotB-4pelB:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 12 LEU B 538
GLY B  58
ASP B 484
GLY B  34
ILE B  35
 None
 0.85A 2nnkB-4pelB:
undetectable		 2nnkB-4pelB:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		3 / 3 ARG B 199
ASN B 125
THR A 150
 None
 0.86A 2q63A-4pelB:
undetectable		 2q63A-4pelB:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 10 ILE A  92
PHE A  28
THR B  48
ILE B  35
LEU B  37
 None
 1.20A 2w3aB-4pelA:
undetectable		 2w3aB-4pelA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_T_CHDT1085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 10 MET B 485
GLU B 482
THR B 481
PHE B 531
GLY B 532
 None
 1.21A 2y69A-4pelB:
0.0
2y69B-4pelB:
undetectable
2y69T-4pelB:
undetectable		 2y69A-4pelB:
21.29
2y69B-4pelB:
17.12
2y69T-4pelB:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		4 / 7 ASP B 280
ARG B 533
VAL B  19
ILE B  17
 None
 1.07A 2yfbA-4pelB:
undetectable		 2yfbA-4pelB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		4 / 6 ASP B 280
ARG B 533
VAL B  19
ILE B  17
 None
 1.07A 2yfbB-4pelB:
undetectable		 2yfbB-4pelB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 10 PHE B 531
GLY B 532
MET B 485
GLU B 482
THR B 481
 None
 1.24A 3abmG-4pelB:
undetectable
3abmN-4pelB:
0.7
3abmO-4pelB:
undetectable		 3abmG-4pelB:
9.81
3abmN-4pelB:
21.29
3abmO-4pelB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 11 MET B 485
GLU B 482
THR B 481
PHE B 531
GLY B 532
 None
 1.26A 3ag1A-4pelB:
0.8
3ag1B-4pelB:
undetectable
3ag1T-4pelB:
undetectable		 3ag1A-4pelB:
21.29
3ag1B-4pelB:
17.12
3ag1T-4pelB:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 11 PHE B 531
GLY B 532
MET B 485
GLU B 482
THR B 481
 None
 1.27A 3ag1G-4pelB:
undetectable
3ag1N-4pelB:
0.8
3ag1O-4pelB:
undetectable		 3ag1G-4pelB:
9.81
3ag1N-4pelB:
21.29
3ag1O-4pelB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		6 / 12 ALA A 102
LEU B 553
GLN B 554
VAL B 555
ILE A  19
ARG A  26
 None
 1.05A 3datA-4pelA:
undetectable		 3datA-4pelA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 12 GLY B  41
GLY B  61
THR B  62
VAL B 497
ASP B  43
 None
 1.09A 3eluA-4pelB:
undetectable		 3eluA-4pelB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 12 VAL A  35
GLY A  32
GLY A  99
ALA B  51
ILE B  35
 None
 0.94A 3fuuA-4pelA:
undetectable		 3fuuA-4pelA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens;
Kluyvera
cryocrescens) 		5 / 12 GLU A 194
GLY B 235
VAL B   5
ILE B 188
ASN B 187
 None
 1.36A 3jb2A-4pelA:
undetectable		 3jb2A-4pelA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 12 SER B 390
LEU B 351
TRP A 180
GLY B 260
ALA B 261
 None
 1.05A 3ln1D-4pelB:
undetectable		 3ln1D-4pelB:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		4 / 7 TYR A  25
VAL B 148
VAL A 134
MET A 100
 None
 1.06A 3mssB-4pelA:
undetectable		 3mssB-4pelA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_1
(POL POLYPROTEIN)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 9 LEU B 538
GLY B  58
ASP B 484
GLY B  34
ILE B  35
 None
 0.85A 3u7sA-4pelB:
undetectable		 3u7sA-4pelB:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 10 ILE A  92
VAL A 134
PHE A  28
THR B  48
ILE B  35
 None
 1.32A 3um5B-4pelA:
undetectable		 3um5B-4pelA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 11 MET B 485
GLU B 482
THR B 481
PHE B 531
GLY B 532
 None
 1.24A 3wg7A-4pelB:
undetectable
3wg7B-4pelB:
undetectable
3wg7T-4pelB:
undetectable		 3wg7A-4pelB:
21.29
3wg7B-4pelB:
17.12
3wg7T-4pelB:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 10 PHE B 531
GLY B 532
MET B 485
GLU B 482
THR B 481
 None
 1.25A 3wg7G-4pelB:
undetectable
3wg7N-4pelB:
2.1
3wg7O-4pelB:
undetectable		 3wg7G-4pelB:
9.81
3wg7N-4pelB:
21.29
3wg7O-4pelB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 10 PHE B 531
GLY B 532
MET B 485
GLU B 482
THR B 481
 None
 1.21A 3x2qG-4pelB:
undetectable
3x2qN-4pelB:
0.8
3x2qO-4pelB:
undetectable		 3x2qG-4pelB:
9.81
3x2qN-4pelB:
21.29
3x2qO-4pelB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens;
Kluyvera
cryocrescens) 		5 / 12 TYR A  96
GLY A  30
ILE A   9
GLU B 551
VAL A  34
 None
 1.19A 4azsA-4pelA:
undetectable		 4azsA-4pelA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens;
Kluyvera
cryocrescens) 		5 / 12 TYR A  96
GLY A  30
ILE A   9
GLU B 551
VAL A  34
 None
 1.18A 4azwA-4pelA:
undetectable		 4azwA-4pelA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 12 GLY B  46
GLY B  36
ASP B 501
GLY B  66
PRO B  49
 None
 1.10A 4blvA-4pelB:
undetectable		 4blvA-4pelB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens;
Kluyvera
cryocrescens) 		5 / 12 MET A 142
PHE A 138
ASN B  47
ASP B 484
GLY B  66
 None
 1.25A 4djeB-4pelA:
undetectable		 4djeB-4pelA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)		 4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
(Kluyvera
cryocrescens) 		5 / 12 PRO A  75
GLY A 140
ASN A 144
ILE A 137
PHE A 132
 None
 1.34A 4kotA-4pelA:
undetectable		 4kotA-4pelA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 9 ASP A  38
VAL B 503
ALA B 504
GLY A  15
SER B 508
 None
 1.32A 4mmeB-4pelA:
undetectable		 4mmeB-4pelA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 10 LEU B 538
GLY B  58
ASP B 484
GLY B  34
ILE B  35
 None
 0.84A 4njtB-4pelB:
undetectable		 4njtB-4pelB:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 9 ALA B 430
GLY B 343
ALA B 345
THR B 447
VAL B 442
 None
 1.23A 4r1zA-4pelB:
undetectable		 4r1zA-4pelB:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 12 TRP B  65
GLY B  66
GLY B  58
ILE B  35
ASP B 484
 None
 1.18A 4rtsA-4pelB:
undetectable		 4rtsA-4pelB:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		4 / 8 GLU A  88
ASP A  23
ARG A  26
ARG B 557
 None
 1.20A 4uhxA-4pelA:
undetectable		 4uhxA-4pelA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 11 GLY A  95
ALA A  21
ILE A  19
LEU B  37
ILE A  92
 None
 1.11A 4xumB-4pelA:
undetectable		 4xumB-4pelA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 10 PHE B 531
GLY B 532
MET B 485
GLU B 482
THR B 481
 None
 1.26A 5b1aG-4pelB:
undetectable
5b1aN-4pelB:
0.8
5b1aO-4pelB:
undetectable		 5b1aG-4pelB:
9.81
5b1aN-4pelB:
21.29
5b1aO-4pelB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 11 MET B 485
GLU B 482
THR B 481
PHE B 531
GLY B 532
 None
 1.25A 5b3sA-4pelB:
2.0
5b3sB-4pelB:
undetectable
5b3sT-4pelB:
undetectable		 5b3sA-4pelB:
21.29
5b3sB-4pelB:
17.12
5b3sT-4pelB:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_G_CHDG102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 10 PHE B 531
GLY B 532
MET B 485
GLU B 482
THR B 481
 None
 1.23A 5b3sG-4pelB:
undetectable
5b3sN-4pelB:
undetectable
5b3sO-4pelB:
undetectable		 5b3sG-4pelB:
9.81
5b3sN-4pelB:
21.29
5b3sO-4pelB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 12 GLY B  41
GLY B  61
THR B  62
VAL B 497
ASP B  43
 None
 1.06A 5ehiC-4pelB:
undetectable		 5ehiC-4pelB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 12 VAL B 543
ASP B 542
HIS B  38
LEU B  37
LEU B  55
 None
 1.04A 5hnwB-4pelB:
undetectable		 5hnwB-4pelB:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 12 VAL B 543
ASP B 542
HIS B  38
LEU B  37
LEU B  55
 None
 1.06A 5hnxB-4pelB:
undetectable		 5hnxB-4pelB:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 12 VAL B 543
ASP B 542
HIS B  38
LEU B  37
LEU B  55
 None
 1.03A 5hnyB-4pelB:
undetectable		 5hnyB-4pelB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_G_CHDG102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 10 PHE B 531
GLY B 532
MET B 485
GLU B 482
THR B 481
 None
 1.23A 5iy5G-4pelB:
undetectable
5iy5N-4pelB:
undetectable
5iy5O-4pelB:
undetectable		 5iy5G-4pelB:
9.73
5iy5N-4pelB:
21.29
5iy5O-4pelB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		4 / 8 ASP B 293
TYR B 339
SER B 386
ASN B 478
 None
 0.92A 5l1fA-4pelB:
undetectable
5l1fB-4pelB:
undetectable		 5l1fA-4pelB:
21.24
5l1fB-4pelB:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 12 ILE B 188
GLY B 189
ALA B 182
ILE B  17
ALA B  16
 None
 1.00A 5n0tB-4pelB:
undetectable		 5n0tB-4pelB:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_D_SAMD301_0
(NS5)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 12 GLY B  41
GLY B  61
THR B  62
VAL B 497
ASP B  43
 None
 1.02A 5njvD-4pelB:
undetectable		 5njvD-4pelB:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 11 PHE B 531
GLY B 532
MET B 485
GLU B 482
THR B 481
 None
 1.28A 5w97G-4pelB:
undetectable
5w97a-4pelB:
undetectable
5w97b-4pelB:
undetectable		 5w97G-4pelB:
9.81
5w97a-4pelB:
21.29
5w97b-4pelB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 11 MET B 485
GLU B 482
THR B 481
PHE B 531
GLY B 532
 None
 1.28A 5w97A-4pelB:
undetectable
5w97B-4pelB:
undetectable
5w97g-4pelB:
undetectable		 5w97A-4pelB:
21.29
5w97B-4pelB:
17.12
5w97g-4pelB:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 10 PHE B 531
GLY B 532
MET B 485
GLU B 482
THR B 481
 None
 1.24A 5wauG-4pelB:
undetectable
5waua-4pelB:
1.0
5waub-4pelB:
undetectable		 5wauG-4pelB:
9.81
5waua-4pelB:
21.29
5waub-4pelB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 12 GLY B  41
GLY B  61
THR B  62
VAL B 497
ASP B  43
 None
 1.05A 5wz1D-4pelB:
undetectable		 5wz1D-4pelB:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 12 GLY B  41
GLY B  61
THR B  62
VAL B 497
ASP B  43
 None
 1.05A 5wz1F-4pelB:
undetectable		 5wz1F-4pelB:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 11 MET B 485
GLU B 482
THR B 481
PHE B 531
GLY B 532
 None
 1.23A 5x19A-4pelB:
1.6
5x19B-4pelB:
undetectable
5x19T-4pelB:
undetectable		 5x19A-4pelB:
21.29
5x19B-4pelB:
17.12
5x19T-4pelB:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 10 MET B 485
GLU B 482
THR B 481
PHE B 531
GLY B 532
 None
 1.22A 5x1bA-4pelB:
undetectable
5x1bB-4pelB:
undetectable
5x1bT-4pelB:
undetectable		 5x1bA-4pelB:
21.29
5x1bB-4pelB:
17.12
5x1bT-4pelB:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 11 PHE B 531
GLY B 532
MET B 485
GLU B 482
THR B 481
 None
 1.25A 5x1bG-4pelB:
undetectable
5x1bN-4pelB:
undetectable
5x1bO-4pelB:
undetectable		 5x1bG-4pelB:
9.81
5x1bN-4pelB:
21.29
5x1bO-4pelB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 10 MET B 485
GLU B 482
THR B 481
PHE B 531
GLY B 532
 None
 1.23A 5x1fA-4pelB:
1.0
5x1fB-4pelB:
undetectable
5x1fT-4pelB:
undetectable		 5x1fA-4pelB:
21.29
5x1fB-4pelB:
17.12
5x1fT-4pelB:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 11 PHE B 531
GLY B 532
MET B 485
GLU B 482
THR B 481
 None
 1.23A 5x1fG-4pelB:
undetectable
5x1fN-4pelB:
undetectable
5x1fO-4pelB:
undetectable		 5x1fG-4pelB:
9.81
5x1fN-4pelB:
21.29
5x1fO-4pelB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 11 MET B 485
GLU B 482
THR B 481
PHE B 531
GLY B 532
 None
 1.23A 5xdqA-4pelB:
0.8
5xdqB-4pelB:
undetectable
5xdqT-4pelB:
undetectable		 5xdqA-4pelB:
21.29
5xdqB-4pelB:
17.12
5xdqT-4pelB:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_G_CHDG102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 10 PHE B 531
GLY B 532
MET B 485
GLU B 482
THR B 481
 None
 1.24A 5xdqG-4pelB:
undetectable
5xdqN-4pelB:
0.8
5xdqO-4pelB:
undetectable		 5xdqG-4pelB:
9.81
5xdqN-4pelB:
21.29
5xdqO-4pelB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 11 MET B 485
GLU B 482
THR B 481
PHE B 531
GLY B 532
 None
 1.25A 5xdxA-4pelB:
0.7
5xdxB-4pelB:
undetectable
5xdxT-4pelB:
undetectable		 5xdxA-4pelB:
21.29
5xdxB-4pelB:
17.12
5xdxT-4pelB:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens;
Kluyvera
cryocrescens) 		3 / 3 MET B 527
ASP B 501
ARG A  39
 None
 0.97A 5z6jA-4pelB:
undetectable		 5z6jA-4pelB:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens;
Kluyvera
cryocrescens) 		3 / 3 MET B 527
ASP B 501
ARG A  39
 None
 0.93A 5z6kA-4pelB:
undetectable		 5z6kA-4pelB:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 10 PHE B 531
GLY B 532
MET B 485
GLU B 482
THR B 481
 None
 1.26A 5z85G-4pelB:
undetectable
5z85N-4pelB:
undetectable
5z85O-4pelB:
undetectable		 5z85G-4pelB:
9.81
5z85N-4pelB:
21.29
5z85O-4pelB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_G_CHDG102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 10 PHE B 531
GLY B 532
MET B 485
GLU B 482
THR B 481
 None
 1.23A 5zcoG-4pelB:
undetectable
5zcoN-4pelB:
undetectable
5zcoO-4pelB:
undetectable		 5zcoG-4pelB:
9.81
5zcoN-4pelB:
21.29
5zcoO-4pelB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_G_CHDG102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 10 PHE B 531
GLY B 532
MET B 485
GLU B 482
THR B 481
 None
 1.25A 5zcpG-4pelB:
undetectable
5zcpN-4pelB:
0.8
5zcpO-4pelB:
undetectable		 5zcpG-4pelB:
9.81
5zcpN-4pelB:
21.29
5zcpO-4pelB:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens;
Kluyvera
cryocrescens) 		4 / 8 TYR B  42
GLY B  36
ILE A  19
ASP B  43
 None
 0.92A 6ag0A-4pelB:
undetectable		 6ag0A-4pelB:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		3 / 3 TRP B   4
ILE B 286
GLU B 482
 None
 0.77A 6hcxA-4pelB:
undetectable		 6hcxA-4pelB:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		4 / 8 ASP B 305
ILE B 423
TRP B 350
TYR B 397
 None
 1.25A 6hisA-4pelB:
undetectable
6hisB-4pelB:
undetectable		 6hisA-4pelB:
8.71
6hisB-4pelB:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		4 / 8 ASP B 305
ILE B 423
TRP B 350
TYR B 397
 None
 1.25A 6hisB-4pelB:
undetectable
6hisC-4pelB:
undetectable		 6hisB-4pelB:
8.71
6hisC-4pelB:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		4 / 8 ASP B 305
ILE B 423
TRP B 350
TYR B 397
 None
 1.25A 6hisC-4pelB:
undetectable
6hisD-4pelB:
undetectable		 6hisC-4pelB:
8.71
6hisD-4pelB:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		4 / 8 ASP B 305
ILE B 423
TRP B 350
TYR B 397
 None
 1.25A 6hisD-4pelB:
undetectable
6hisE-4pelB:
undetectable		 6hisD-4pelB:
8.71
6hisE-4pelB:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		4 / 8 TYR B 397
ASP B 305
ILE B 423
TRP B 350
 None
 1.25A 6hisA-4pelB:
undetectable
6hisE-4pelB:
undetectable		 6hisA-4pelB:
8.71
6hisE-4pelB:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4pel PENICILLIN G ACYLASE
SUBUNIT BETA
(Kluyvera
cryocrescens) 		5 / 11 MET B 485
GLU B 482
THR B 481
PHE B 531
GLY B 532
 None
 1.23A 6nknA-4pelB:
undetectable
6nknB-4pelB:
undetectable
6nknT-4pelB:
undetectable		 6nknA-4pelB:
21.29
6nknB-4pelB:
17.12
6nknT-4pelB:
9.81