SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4peq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		5 / 11 ARG B 441
LEU B 414
GLU B 418
ALA B 386
GLY B 384
 None
 1.22A 1cmaA-4peqB:
undetectable
1cmaB-4peqB:
undetectable		 1cmaA-4peqB:
11.49
1cmaB-4peqB:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		5 / 11 LEU B  72
LEU B  92
LEU B 120
LEU B  85
LEU B  87
 None
 0.88A 1mx1B-4peqB:
undetectable		 1mx1B-4peqB:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		4 / 7 VAL B  71
VAL B  28
LEU B   3
LEU B  47
 None
 0.77A 1pthA-4peqB:
undetectable		 1pthA-4peqB:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		4 / 7 VAL B  71
VAL B  28
LEU B   3
LEU B  47
 None
 0.77A 1pthB-4peqB:
undetectable		 1pthB-4peqB:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		4 / 7 LEU B 400
VAL B 372
GLY B 373
ASP B 350
 None
 1.00A 1t88A-4peqB:
undetectable		 1t88A-4peqB:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		4 / 4 GLY B 245
SER B 251
VAL B 274
LEU B 242
 None
 0.89A 1yajB-4peqB:
undetectable		 1yajB-4peqB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		4 / 8 LEU B 400
VAL B 372
GLY B 373
ASP B 350
 None
 0.92A 2a1oA-4peqB:
undetectable		 2a1oA-4peqB:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		3 / 3 SER B  57
ASP B 117
CYH B 147
 None
 1.12A 2br4E-4peqB:
undetectable		 2br4E-4peqB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		5 / 12 LEU B  53
LEU B  75
GLN B  76
LEU B  87
THR B 109
 None
 1.16A 3ix9A-4peqB:
undetectable		 3ix9A-4peqB:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		4 / 6 ILE B 177
VAL B 172
LEU B 144
LEU B 125
 None
 0.92A 3kp6A-4peqB:
undetectable
3kp6B-4peqB:
undetectable		 3kp6A-4peqB:
14.16
3kp6B-4peqB:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB665_1
(ALPHA-GLUCOSIDASE)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		4 / 6 GLU B 283
ASP B 226
ASP B 228
LYS B 200
 None
 1.38A 3pocB-4peqB:
0.5		 3pocB-4peqB:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		4 / 4 LEU B 348
GLY B 349
LEU B 377
GLU B 376
 None
 1.11A 3tgvB-4peqB:
undetectable		 3tgvB-4peqB:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		5 / 12 LEU B 271
GLY B 238
CYH B 243
ARG B 233
ASP B 262
 None
 1.21A 3uj7B-4peqB:
undetectable		 3uj7B-4peqB:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		4 / 8 GLY B 352
ASP B 350
GLY B 349
VAL B 372
 None
 0.88A 4c5nC-4peqB:
undetectable		 4c5nC-4peqB:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		5 / 12 LEU B 275
ALA B 287
LEU B 239
LEU B 242
GLY B 245
 None
 1.20A 4l9qB-4peqB:
undetectable		 4l9qB-4peqB:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		5 / 12 LEU B  58
LEU B  63
ILE B  43
GLY B  34
LEU B  30
 None
 0.89A 4lmnA-4peqB:
undetectable		 4lmnA-4peqB:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		4 / 5 CYH B 300
LEU B 338
LEU B 370
LEU B 313
 None
 1.26A 4n09D-4peqB:
undetectable		 4n09D-4peqB:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		4 / 5 CYH B 324
LEU B 343
LEU B 313
LEU B 356
 None
 1.26A 4n09D-4peqB:
undetectable		 4n09D-4peqB:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		4 / 5 CYH B 357
LEU B 395
LEU B 427
LEU B 370
 None
 1.26A 4n09D-4peqB:
undetectable		 4n09D-4peqB:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		5 / 12 LEU B 414
GLU B 446
VAL B 445
ARG B 443
GLU B 436
 None
 1.28A 4q15B-4peqB:
undetectable		 4q15B-4peqB:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		5 / 11 LEU B  75
LEU B  72
GLU B  55
LEU B  85
LEU B  87
 None
 1.03A 4wg0H-4peqB:
undetectable
4wg0I-4peqB:
undetectable
4wg0J-4peqB:
undetectable		 4wg0H-4peqB:
5.61
4wg0I-4peqB:
5.61
4wg0J-4peqB:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		5 / 11 LEU B  87
GLU B  55
LEU B  85
LEU B  75
LEU B  72
 None
 1.07A 4wg0K-4peqB:
undetectable
4wg0L-4peqB:
undetectable
4wg0M-4peqB:
undetectable		 4wg0K-4peqB:
5.61
4wg0L-4peqB:
5.61
4wg0M-4peqB:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		5 / 12 ARG B 269
LEU B 299
LEU B 263
VAL B 265
GLY B 267
 None
 1.04A 5ikqA-4peqB:
undetectable		 5ikqA-4peqB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		5 / 12 ARG B 269
LEU B 299
LEU B 263
VAL B 265
GLY B 267
 None
 1.04A 5ikqB-4peqB:
undetectable		 5ikqB-4peqB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		4 / 4 ASN B 346
LEU B 348
SER B 344
LEU B 370
 None
 1.28A 5kb5A-4peqB:
undetectable		 5kb5A-4peqB:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		5 / 12 ALA B 180
GLY B 181
ASN B 174
GLU B 145
LEU B 201
 None
 1.22A 5nwuA-4peqB:
undetectable		 5nwuA-4peqB:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		5 / 12 LEU B 414
GLU B 446
VAL B 445
ARG B 443
GLU B 436
 None
 1.16A 5xipD-4peqB:
undetectable		 5xipD-4peqB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		5 / 12 LEU B 414
GLU B 446
VAL B 445
ARG B 443
GLU B 436
 None
 1.24A 5xiqD-4peqB:
undetectable		 5xiqD-4peqB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		5 / 12 LEU B 227
LEU B 214
LEU B 229
GLY B 267
LEU B 263
 None
 0.99A 6b0cD-4peqB:
undetectable		 6b0cD-4peqB:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		3 / 3 ILE B 177
ASN B 232
CYH B 211
 None
 0.73A 6bp4A-4peqB:
undetectable		 6bp4A-4peqB:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		6 / 9 VAL B  99
LEU B  85
GLY B  74
LEU B  75
GLN B  76
VAL B  68
 None
 1.47A 6czmA-4peqB:
undetectable
6czmB-4peqB:
undetectable		 6czmA-4peqB:
24.35
6czmB-4peqB:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		5 / 9 VAL B  99
LEU B  85
GLY B  74
LEU B  75
VAL B  68
 None
 1.24A 6czmB-4peqB:
undetectable
6czmC-4peqB:
undetectable		 6czmB-4peqB:
24.35
6czmC-4peqB:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		5 / 9 VAL B  99
LEU B  85
GLY B  74
LEU B  75
VAL B  68
 None
 1.22A 6czmD-4peqB:
undetectable
6czmE-4peqB:
undetectable		 6czmD-4peqB:
24.35
6czmE-4peqB:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		5 / 10 VAL B  99
LEU B  85
GLY B  74
LEU B  75
VAL B  68
 None
 1.25A 6czmE-4peqB:
undetectable
6czmF-4peqB:
undetectable		 6czmE-4peqB:
24.35
6czmF-4peqB:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1
(Bos
taurus) 		4 / 7 LEU B 356
VAL B 315
LEU B 341
LEU B 338
 None
 0.70A 6g9bA-4peqB:
undetectable
6g9bB-4peqB:
undetectable		 6g9bA-4peqB:
11.90
6g9bB-4peqB:
10.29