SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pet'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Colwellia
psychrerythraea) 		4 / 6 LEU A 222
TRP A 217
PHE A  49
TYR A 101
 None
PYR  A 402 ( 4.1A)
PYR  A 402 (-4.2A)
None
 1.32A 1ibgH-4petA:
undetectable		 1ibgH-4petA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J78_B_VDYB500_1
(VITAMIN D BINDING
PROTEIN)		 4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Colwellia
psychrerythraea) 		5 / 10 GLU A 216
VAL A 218
PHE A  49
TYR A 102
LEU A  82
 CA  A 403 ( 2.1A)
PYR  A 402 ( 4.6A)
PYR  A 402 (-4.2A)
PYR  A 402 (-4.4A)
None
 1.47A 1j78B-4petA:
0.0		 1j78B-4petA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Colwellia
psychrerythraea) 		3 / 3 TRP A 217
PHE A  49
TRP A  42
 PYR  A 402 ( 4.1A)
PYR  A 402 (-4.2A)
None
 1.37A 1r15C-4petA:
undetectable		 1r15C-4petA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Colwellia
psychrerythraea) 		3 / 3 TRP A 217
PHE A  49
TRP A  42
 PYR  A 402 ( 4.1A)
PYR  A 402 (-4.2A)
None
 1.36A 1r15F-4petA:
undetectable		 1r15F-4petA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Colwellia
psychrerythraea) 		3 / 3 TRP A 217
PHE A  49
TRP A  42
 PYR  A 402 ( 4.1A)
PYR  A 402 (-4.2A)
None
 1.37A 1r15G-4petA:
undetectable		 1r15G-4petA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Colwellia
psychrerythraea) 		3 / 3 TRP A 217
PHE A  49
TRP A  42
 PYR  A 402 ( 4.1A)
PYR  A 402 (-4.2A)
None
 1.36A 1r15H-4petA:
undetectable		 1r15H-4petA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Colwellia
psychrerythraea) 		4 / 7 TYR A 235
THR A 244
THR A 155
SER A 221
 None
PYR  A 402 ( 4.1A)
PYR  A 402 ( 4.9A)
None
 1.17A 1tv8A-4petA:
undetectable		 1tv8A-4petA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Colwellia
psychrerythraea) 		3 / 3 SER A 200
GLU A  40
ASP A  51
 None
 0.77A 2avdB-4petA:
undetectable		 2avdB-4petA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Colwellia
psychrerythraea) 		4 / 8 TYR A 235
THR A 244
THR A 155
SER A 221
 None
PYR  A 402 ( 4.1A)
PYR  A 402 ( 4.9A)
None
 1.15A 2fb2A-4petA:
undetectable		 2fb2A-4petA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Colwellia
psychrerythraea) 		4 / 7 TYR A 235
THR A 244
THR A 155
SER A 221
 None
PYR  A 402 ( 4.1A)
PYR  A 402 ( 4.9A)
None
 1.11A 2fb2B-4petA:
undetectable		 2fb2B-4petA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Colwellia
psychrerythraea) 		5 / 11 GLY A  43
GLU A  40
LEU A 222
ARG A 225
GLY A  50
 None
 1.17A 2fn1A-4petA:
undetectable		 2fn1A-4petA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Colwellia
psychrerythraea) 		4 / 6 TRP A  42
GLY A  83
GLY A  96
GLN A 247
 None
 0.95A 2qx6A-4petA:
undetectable
2qx6B-4petA:
undetectable		 2qx6A-4petA:
20.33
2qx6B-4petA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Colwellia
psychrerythraea) 		4 / 6 SER A 200
PRO A  44
GLY A  43
TRP A  42
 None
 1.43A 2y7pA-4petA:
4.0		 2y7pA-4petA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Colwellia
psychrerythraea) 		5 / 12 PHE A 304
LEU A 188
ALA A 214
PHE A 163
TYR A 236
 None
 1.29A 3apxA-4petA:
undetectable		 3apxA-4petA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Colwellia
psychrerythraea) 		4 / 4 THR A 115
VAL A 218
GLY A 238
THR A 237
 None
PYR  A 402 ( 4.6A)
None
None
 1.10A 3cflA-4petA:
1.6		 3cflA-4petA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Colwellia
psychrerythraea) 		5 / 12 GLY A 152
GLY A 153
ALA A  52
PHE A 150
ALA A  99
 None
None
None
None
PYR  A 402 ( 4.4A)
 1.01A 3jb2A-4petA:
undetectable		 3jb2A-4petA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Colwellia
psychrerythraea) 		3 / 3 PHE A  49
SER A 221
SER A 281
 PYR  A 402 (-4.2A)
None
None
 0.88A 3ufgB-4petA:
undetectable		 3ufgB-4petA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Colwellia
psychrerythraea) 		5 / 12 PHE A 150
PRO A 151
PHE A 129
LEU A 337
ILE A 333
 None
 1.42A 4a83A-4petA:
undetectable		 4a83A-4petA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Colwellia
psychrerythraea) 		5 / 12 PRO A 199
ARG A 179
ALA A 184
GLY A 185
LEU A 188
 None
PYR  A 402 (-2.8A)
None
None
None
 1.42A 4oadA-4petA:
undetectable		 4oadA-4petA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Colwellia
psychrerythraea) 		5 / 10 TYR A 102
LEU A 246
LEU A  38
ALA A  57
GLY A  50
 PYR  A 402 (-4.4A)
PYR  A 402 ( 4.6A)
None
None
None
 1.47A 4rn6A-4petA:
undetectable		 4rn6A-4petA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Colwellia
psychrerythraea) 		5 / 12 GLU A 186
ILE A 312
ALA A 311
VAL A 308
PHE A 304
 None
 1.17A 4u95B-4petA:
undetectable		 4u95B-4petA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJQ_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Colwellia
psychrerythraea) 		5 / 12 MET A 249
ILE A  84
ARG A 179
GLU A 216
GLU A 241
 None
None
PYR  A 402 (-2.8A)
CA  A 403 ( 2.1A)
CA  A 403 ( 2.5A)
 1.38A 4zjqD-4petA:
undetectable		 4zjqD-4petA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Colwellia
psychrerythraea) 		4 / 7 VAL A 250
LEU A 258
MET A  56
VAL A  60
 None
 1.00A 5e4dA-4petA:
undetectable
5e4dB-4petA:
undetectable		 5e4dA-4petA:
21.97
5e4dB-4petA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Colwellia
psychrerythraea) 		4 / 4 GLN A 125
THR A 114
THR A 330
LEU A 320
 None
 1.49A 5m5kA-4petA:
undetectable		 5m5kA-4petA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Colwellia
psychrerythraea) 		4 / 4 GLN A 125
THR A 114
THR A 330
LEU A 320
 None
 1.48A 5m5kC-4petA:
undetectable		 5m5kC-4petA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Colwellia
psychrerythraea) 		3 / 3 SER A 281
SER A 285
PHE A  49
 None
None
PYR  A 402 (-4.2A)
 0.78A 5mugA-4petA:
undetectable		 5mugA-4petA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Colwellia
psychrerythraea) 		3 / 3 GLY A 219
VAL A 299
MET A 301
 None
 0.59A 5ycpA-4petA:
undetectable		 5ycpA-4petA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		 4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Colwellia
psychrerythraea) 		5 / 10 THR A 244
GLY A 153
LEU A 246
TYR A 101
HIS A  97
 PYR  A 402 ( 4.1A)
None
PYR  A 402 ( 4.6A)
None
None
 1.23A 6gnfC-4petA:
undetectable		 6gnfC-4petA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7
(Colwellia
psychrerythraea) 		5 / 12 GLY A 185
LEU A 188
THR A 244
GLY A 243
ASN A 316
 None
None
PYR  A 402 ( 4.1A)
None
None
 1.12A 6gngA-4petA:
undetectable		 6gngA-4petA:
19.65