SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pev'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4pev MEMBRANE LIPOPROTEIN
FAMILY PROTEIN
(Aeropyrum
pernix) 		5 / 11 LEU A 323
LEU A 358
ALA A 196
TYR A 277
GLN A 306
 None
 1.23A 1iiuA-4pevA:
undetectable		 1iiuA-4pevA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4pev MEMBRANE LIPOPROTEIN
FAMILY PROTEIN
(Aeropyrum
pernix) 		5 / 12 LEU A 323
LEU A 358
ALA A 196
TYR A 277
GLN A 306
 None
 1.23A 1kt4A-4pevA:
undetectable		 1kt4A-4pevA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4pev MEMBRANE LIPOPROTEIN
FAMILY PROTEIN
(Aeropyrum
pernix) 		5 / 11 LEU A 323
LEU A 358
ALA A 196
TYR A 277
GLN A 306
 None
 1.20A 1kt7A-4pevA:
undetectable		 1kt7A-4pevA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 4pev MEMBRANE LIPOPROTEIN
FAMILY PROTEIN
(Aeropyrum
pernix) 		5 / 12 THR A 243
ILE A 198
GLY A 402
PHE A 302
ASN A 200
 None
 1.10A 1nv8A-4pevA:
2.5		 1nv8A-4pevA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4pev MEMBRANE LIPOPROTEIN
FAMILY PROTEIN
(Aeropyrum
pernix) 		4 / 5 SER A 321
SER A 359
PHE A 288
VAL A 390
 None
 1.45A 1oipA-4pevA:
undetectable		 1oipA-4pevA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4pev MEMBRANE LIPOPROTEIN
FAMILY PROTEIN
(Aeropyrum
pernix) 		4 / 6 ARG A 171
ASN A 176
PRO A 156
ALA A 155
 None
 1.39A 2ejfB-4pevA:
1.2		 2ejfB-4pevA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 4pev MEMBRANE LIPOPROTEIN
FAMILY PROTEIN
(Aeropyrum
pernix) 		5 / 12 ASP A  85
GLY A 144
ASP A 167
PHE A 226
GLY A 217
 ADN  A 501 (-3.8A)
ADN  A 501 ( 4.1A)
ADN  A 501 (-3.2A)
ADN  A 501 (-4.7A)
None
 1.49A 2fqyA-4pevA:
40.2		 2fqyA-4pevA:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 4pev MEMBRANE LIPOPROTEIN
FAMILY PROTEIN
(Aeropyrum
pernix) 		10 / 12 ASP A  85
PHE A  94
ASN A  95
GLY A 144
ASP A 167
PHE A 226
PHE A 255
GLY A 281
ASP A 307
LYS A 324
 ADN  A 501 (-3.8A)
ADN  A 501 (-3.9A)
ADN  A 501 (-3.5A)
ADN  A 501 ( 4.1A)
ADN  A 501 (-3.2A)
ADN  A 501 (-4.7A)
ADN  A 501 (-3.4A)
ADN  A 501 (-3.2A)
ADN  A 501 (-2.6A)
ADN  A 501 (-3.0A)
 0.63A 2fqyA-4pevA:
40.2		 2fqyA-4pevA:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 4pev MEMBRANE LIPOPROTEIN
FAMILY PROTEIN
(Aeropyrum
pernix) 		6 / 12 PHE A  94
ASN A  95
GLY A 144
ASP A 167
GLY A 281
VAL A 279
 ADN  A 501 (-3.9A)
ADN  A 501 (-3.5A)
ADN  A 501 ( 4.1A)
ADN  A 501 (-3.2A)
ADN  A 501 (-3.2A)
ADN  A 501 ( 4.2A)
 1.49A 2fqyA-4pevA:
40.2		 2fqyA-4pevA:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_1
(PROTEASE)		 4pev MEMBRANE LIPOPROTEIN
FAMILY PROTEIN
(Aeropyrum
pernix) 		5 / 12 LEU A 139
ALA A 102
ASP A 103
VAL A 326
ILE A 334
 None
 1.18A 2o4lA-4pevA:
undetectable		 2o4lA-4pevA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4pev MEMBRANE LIPOPROTEIN
FAMILY PROTEIN
(Aeropyrum
pernix) 		5 / 12 PHE A 276
SER A 303
ASN A 289
GLY A 261
ALA A 265
 None
 1.17A 2x2iA-4pevA:
undetectable		 2x2iA-4pevA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4pev MEMBRANE LIPOPROTEIN
FAMILY PROTEIN
(Aeropyrum
pernix) 		5 / 10 PHE A 276
SER A 303
ASN A 289
GLY A 261
ALA A 265
 None
 1.13A 2x2iB-4pevA:
undetectable		 2x2iB-4pevA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4pev MEMBRANE LIPOPROTEIN
FAMILY PROTEIN
(Aeropyrum
pernix) 		5 / 12 PHE A 276
SER A 303
ASN A 289
GLY A 261
ALA A 265
 None
 1.21A 2x2iC-4pevA:
undetectable		 2x2iC-4pevA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4pev MEMBRANE LIPOPROTEIN
FAMILY PROTEIN
(Aeropyrum
pernix) 		5 / 12 PHE A  94
GLY A  90
ASN A  95
ASP A 327
PHE A 367
 ADN  A 501 (-3.9A)
None
ADN  A 501 (-3.5A)
None
None
 1.10A 2zznB-4pevA:
undetectable		 2zznB-4pevA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 4pev MEMBRANE LIPOPROTEIN
FAMILY PROTEIN
(Aeropyrum
pernix) 		3 / 3 LEU A 323
GLU A 362
ILE A 364
 None
 0.56A 3czhA-4pevA:
undetectable		 3czhA-4pevA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 4pev MEMBRANE LIPOPROTEIN
FAMILY PROTEIN
(Aeropyrum
pernix) 		5 / 12 GLY A 322
GLY A 305
GLY A 278
ASP A 360
ASP A 307
 None
None
None
None
ADN  A 501 (-2.6A)
 1.06A 3ihtA-4pevA:
3.2		 3ihtA-4pevA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4pev MEMBRANE LIPOPROTEIN
FAMILY PROTEIN
(Aeropyrum
pernix) 		5 / 12 GLY A 278
PHE A 226
ALA A 188
VAL A 191
ALA A 216
 None
ADN  A 501 (-4.7A)
None
None
None
 1.29A 4df3A-4pevA:
2.9		 4df3A-4pevA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 4pev MEMBRANE LIPOPROTEIN
FAMILY PROTEIN
(Aeropyrum
pernix) 		5 / 12 ALA A 280
THR A 252
GLU A 266
ALA A 265
THR A 264
 None
 1.16A 4fiaA-4pevA:
undetectable		 4fiaA-4pevA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4pev MEMBRANE LIPOPROTEIN
FAMILY PROTEIN
(Aeropyrum
pernix) 		5 / 12 ALA A 280
THR A 252
GLU A 266
ALA A 265
THR A 264
 None
 1.16A 4fiaA-4pevA:
undetectable		 4fiaA-4pevA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4pev MEMBRANE LIPOPROTEIN
FAMILY PROTEIN
(Aeropyrum
pernix) 		5 / 12 LEU A 356
GLU A 186
GLY A 192
ALA A 196
LEU A 441
 None
 1.27A 4retA-4pevA:
undetectable		 4retA-4pevA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4pev MEMBRANE LIPOPROTEIN
FAMILY PROTEIN
(Aeropyrum
pernix) 		5 / 12 LEU A 356
GLU A 186
GLY A 192
ALA A 196
LEU A 441
 None
 1.26A 4retC-4pevA:
undetectable		 4retC-4pevA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_1
(SERUM ALBUMIN)		 4pev MEMBRANE LIPOPROTEIN
FAMILY PROTEIN
(Aeropyrum
pernix) 		4 / 6 ASN A 176
PHE A 342
LEU A 151
SER A 132
 None
 1.07A 6a7pB-4pevA:
undetectable		 6a7pB-4pevA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4pev MEMBRANE LIPOPROTEIN
FAMILY PROTEIN
(Aeropyrum
pernix) 		4 / 5 ALA A 188
TYR A 230
GLN A 306
ILE A 304
 None
 1.25A 6f6sA-4pevA:
undetectable
6f6sB-4pevA:
undetectable		 6f6sA-4pevA:
12.53
6f6sB-4pevA:
11.34