SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pf1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		5 / 9 LEU A 361
ASP A 358
LEU A 357
THR A  91
ILE A  97
 None
 1.48A 1hzeA-4pf1A:
undetectable
1hzeB-4pf1A:
undetectable		 1hzeA-4pf1A:
10.16
1hzeB-4pf1A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		5 / 9 ILE A  97
LEU A 361
ASP A 358
LEU A 357
THR A  91
 None
 1.48A 1hzeA-4pf1A:
undetectable
1hzeB-4pf1A:
undetectable		 1hzeA-4pf1A:
10.16
1hzeB-4pf1A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IA0_B_TXLB502_1
(TUBULIN BETA CHAIN)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		5 / 12 ASP A 466
ASP A 456
HIS A 460
THR A 440
PRO A 432
 None
 1.47A 1ia0B-4pf1A:
undetectable		 1ia0B-4pf1A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		5 / 11 GLY A 289
PHE A 348
GLY A 328
GLY A 157
GLY A 156
 None
 1.07A 1mxgA-4pf1A:
undetectable		 1mxgA-4pf1A:
20.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		6 / 8 TYR A  66
ARG A  71
TYR A 107
GLU A 160
GLN A 211
HIS A 325
 None
 0.28A 1nx9A-4pf1A:
52.2		 1nx9A-4pf1A:
48.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		6 / 8 TYR A  66
ARG A  71
TYR A 107
GLU A 160
GLN A 211
HIS A 325
 None
 0.29A 1nx9B-4pf1A:
52.3		 1nx9B-4pf1A:
48.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		6 / 8 TYR A  66
ARG A  71
TYR A 107
GLU A 160
GLN A 211
HIS A 325
 None
 0.30A 1nx9C-4pf1A:
52.2		 1nx9C-4pf1A:
48.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		6 / 8 TYR A  66
ARG A  71
TYR A 107
GLU A 160
GLN A 211
HIS A 325
 None
 0.29A 1nx9D-4pf1A:
52.3		 1nx9D-4pf1A:
48.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		5 / 12 ASN A 237
ASP A 582
ARG A 533
PRO A 260
ASP A 263
 None
 1.32A 1s14A-4pf1A:
undetectable		 1s14A-4pf1A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		5 / 12 ASN A 237
ASP A 582
ARG A 533
PRO A 260
ASP A 263
 None
 1.28A 1s14B-4pf1A:
undetectable		 1s14B-4pf1A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		6 / 12 ALA A 182
GLY A 157
GLY A 156
ILE A 296
GLY A 190
PRO A 300
 None
 1.26A 1sqfA-4pf1A:
undetectable		 1sqfA-4pf1A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUB_B_TXLB501_1
(TUBULIN)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		5 / 12 ASP A 466
ASP A 456
HIS A 460
THR A 440
PRO A 432
 None
 1.47A 1tubB-4pf1A:
4.0		 1tubB-4pf1A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_D_DESD128_1
(TRANSTHYRETIN)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		4 / 4 LYS A 548
LEU A 550
LEU A 544
SER A 496
 None
 1.37A 1tz8D-4pf1A:
2.5		 1tz8D-4pf1A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		5 / 12 LEU A 403
ILE A 619
PHE A 563
LEU A 479
LEU A 411
 None
 0.75A 1xdkF-4pf1A:
undetectable		 1xdkF-4pf1A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		3 / 3 ARG A 436
SER A 448
TYR A 435
 None
 0.98A 2q2hA-4pf1A:
undetectable
2q2hB-4pf1A:
undetectable		 2q2hA-4pf1A:
12.46
2q2hB-4pf1A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		5 / 12 LEU A 320
GLY A 288
VAL A 179
ILE A 296
ASP A 295
 None
None
None
None
GOL  A 705 ( 4.6A)
 0.85A 3cjtC-4pf1A:
undetectable		 3cjtC-4pf1A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		5 / 12 THR A 168
HIS A 278
LEU A 306
ILE A 286
LEU A 119
 None
 1.29A 3gwxB-4pf1A:
undetectable		 3gwxB-4pf1A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		4 / 4 GLY A 298
TYR A 297
GLY A 190
ASP A 186
 None
None
None
GOL  A 703 (-4.9A)
 0.96A 3kl3A-4pf1A:
undetectable		 3kl3A-4pf1A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		4 / 7 ARG A  74
LEU A  49
THR A  64
ARG A  70
 None
 1.03A 3nxuA-4pf1A:
undetectable		 3nxuA-4pf1A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		5 / 11 ILE A 622
ALA A 482
GLY A 483
GLY A 321
HIS A 383
 None
 1.02A 4e47A-4pf1A:
undetectable		 4e47A-4pf1A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		5 / 11 ILE A 622
ALA A 482
GLY A 483
GLY A 321
HIS A 383
 None
 1.01A 4e47B-4pf1A:
undetectable		 4e47B-4pf1A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		3 / 3 TYR A  66
ARG A 329
HIS A 325
 None
 1.13A 4fubA-4pf1A:
undetectable		 4fubA-4pf1A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		5 / 11 ILE A 622
ALA A 482
GLY A 483
GLY A 321
HIS A 383
 None
 1.06A 4jdsA-4pf1A:
undetectable		 4jdsA-4pf1A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		5 / 11 ILE A 622
ALA A 482
GLY A 483
GLY A 321
HIS A 383
 None
 1.06A 4jdsB-4pf1A:
undetectable		 4jdsB-4pf1A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		5 / 12 ILE A 622
ALA A 482
GLY A 483
GLY A 321
HIS A 383
 None
 1.07A 4jlgA-4pf1A:
undetectable		 4jlgA-4pf1A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		4 / 7 VAL A 607
ALA A 487
ARG A 583
ILE A 529
 None
 0.66A 4uxqA-4pf1A:
undetectable		 4uxqA-4pf1A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		3 / 3 TYR A 613
THR A 615
THR A 610
 None
 0.69A 5aoxB-4pf1A:
undetectable		 5aoxB-4pf1A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		3 / 3 TYR A 613
THR A 615
THR A 610
 None
 0.76A 5aoxE-4pf1A:
undetectable		 5aoxE-4pf1A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		5 / 11 ILE A 622
ALA A 482
GLY A 483
GLY A 321
HIS A 383
 None
 0.98A 5ayfA-4pf1A:
undetectable		 5ayfA-4pf1A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		5 / 12 LEU A 175
ALA A 154
PRO A 180
LEU A 302
LEU A 306
 None
 1.09A 5ljeA-4pf1A:
undetectable		 5ljeA-4pf1A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		4 / 8 GLY A 336
ARG A 436
VAL A 455
ASP A 456
 GOL  A 702 (-3.9A)
None
None
None
 0.91A 5vlmA-4pf1A:
undetectable		 5vlmA-4pf1A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		5 / 12 GLN A 558
GLU A 376
LEU A 290
ASP A 506
PHE A 563
 None
 1.50A 5vlmF-4pf1A:
undetectable		 5vlmF-4pf1A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		5 / 12 ALA A 182
GLY A 156
ASP A 292
ILE A 296
GLY A 451
 None
 1.20A 5wwsB-4pf1A:
undetectable		 5wwsB-4pf1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		4 / 5 MET A 271
TYR A 162
GLY A 161
GLY A 156
 GOL  A 703 ( 4.2A)
GOL  A 703 (-4.3A)
None
None
 1.14A 5x7pA-4pf1A:
undetectable		 5x7pA-4pf1A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		5 / 12 MET A 115
GLU A 294
HIS A 325
ASP A 292
ASP A 192
 None
GOL  A 705 (-3.2A)
None
None
GOL  A 705 (-2.9A)
 1.44A 5ximB-4pf1A:
undetectable		 5ximB-4pf1A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		4 / 8 GLN A  55
VAL A  54
ILE A  50
THR A  30
 None
 1.05A 6cduG-4pf1A:
2.0
6cduH-4pf1A:
undetectable		 6cduG-4pf1A:
18.66
6cduH-4pf1A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		4 / 5 PHE A 181
VAL A 282
MET A 353
VAL A 287
 None
 1.22A 6ekzA-4pf1A:
undetectable		 6ekzA-4pf1A:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		4 / 8 ASP A 497
ARG A 533
VAL A 607
GLN A 484
 None
 1.29A 6fbvD-4pf1A:
undetectable		 6fbvD-4pf1A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4pf1 PEPTIDASE
S15/COCE/NOND
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		4 / 8 GLN A 354
ILE A  59
ALA A 154
VAL A 178
 None
 1.04A 6hu9a-4pf1A:
undetectable
6hu9e-4pf1A:
undetectable		 6hu9a-4pf1A:
19.91
6hu9e-4pf1A:
11.99