SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pf6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4pf6 C4-DICARBOXYLATE-BIN
DING PROTEIN
(Roseobacter
denitrificans) 		4 / 8 PHE A 182
LEU A 236
VAL A 108
PHE A 314
 None
None
PGE  A 402 ( 4.1A)
None
 1.02A 1gsfC-4pf6A:
undetectable		 1gsfC-4pf6A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 4pf6 C4-DICARBOXYLATE-BIN
DING PROTEIN
(Roseobacter
denitrificans) 		5 / 11 LEU A 252
ALA A  88
VAL A 260
MET A  85
LEU A  30
 None
 1.35A 1hbpA-4pf6A:
undetectable		 1hbpA-4pf6A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4pf6 C4-DICARBOXYLATE-BIN
DING PROTEIN
(Roseobacter
denitrificans) 		5 / 12 GLN A  91
LEU A 239
MET A 124
LEU A 139
THR A 130
 KDO  A 401 ( 4.6A)
None
None
None
None
 1.35A 1ya3B-4pf6A:
undetectable		 1ya3B-4pf6A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4pf6 C4-DICARBOXYLATE-BIN
DING PROTEIN
(Roseobacter
denitrificans) 		5 / 10 ILE A 242
ALA A 267
ALA A 268
LEU A  46
ALA A  45
 None
 0.97A 3falC-4pf6A:
undetectable		 3falC-4pf6A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 4pf6 C4-DICARBOXYLATE-BIN
DING PROTEIN
(Roseobacter
denitrificans) 		4 / 6 ASP A 209
PRO A 296
THR A 233
VAL A 150
 None
 1.13A 4yoaA-4pf6A:
undetectable		 4yoaA-4pf6A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4pf6 C4-DICARBOXYLATE-BIN
DING PROTEIN
(Roseobacter
denitrificans) 		5 / 12 ILE A 242
ALA A 267
ALA A 268
LEU A  46
ALA A  45
 None
 0.99A 5uanA-4pf6A:
undetectable		 5uanA-4pf6A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4pf6 C4-DICARBOXYLATE-BIN
DING PROTEIN
(Roseobacter
denitrificans) 		5 / 12 ILE A 242
ALA A 267
ALA A 268
LEU A  46
ALA A  45
 None
 0.96A 5z12B-4pf6A:
undetectable		 5z12B-4pf6A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4pf6 C4-DICARBOXYLATE-BIN
DING PROTEIN
(Roseobacter
denitrificans) 		5 / 12 ILE A 242
ALA A 267
ALA A 268
LEU A  46
ALA A  45
 None
 1.00A 5z12C-4pf6A:
undetectable		 5z12C-4pf6A:
14.46