SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pf8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4pf8 TRAP-T FAMILY
TRANSPORTER, DCTP
(PERIPLASMIC
BINDING) SUBUNIT
(Sulfitobacter
sp.
NAS-14.1) 		4 / 6 ILE A 254
VAL A  50
ILE A 136
ASP A  84
 None
 0.83A 1uwhA-4pf8A:
undetectable		 1uwhA-4pf8A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 4pf8 TRAP-T FAMILY
TRANSPORTER, DCTP
(PERIPLASMIC
BINDING) SUBUNIT
(Sulfitobacter
sp.
NAS-14.1) 		4 / 7 PHE A 149
ASN A 208
HIS A 230
VAL A 169
 None
GTR  A 402 (-2.9A)
None
None
 1.23A 1wu8A-4pf8A:
undetectable
1wu8C-4pf8A:
undetectable		 1wu8A-4pf8A:
23.50
1wu8C-4pf8A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4pf8 TRAP-T FAMILY
TRANSPORTER, DCTP
(PERIPLASMIC
BINDING) SUBUNIT
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 ALA A 206
PHE A 191
ASN A 208
GLY A 205
ILE A 198
 None
GTR  A 402 ( 3.7A)
GTR  A 402 (-2.9A)
None
None
 1.33A 2dcfA-4pf8A:
undetectable		 2dcfA-4pf8A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4pf8 TRAP-T FAMILY
TRANSPORTER, DCTP
(PERIPLASMIC
BINDING) SUBUNIT
(Sulfitobacter
sp.
NAS-14.1) 		5 / 11 ALA A 206
PHE A 191
ASN A 208
GLY A 205
ILE A 198
 None
GTR  A 402 ( 3.7A)
GTR  A 402 (-2.9A)
None
None
 1.33A 2zmaA-4pf8A:
undetectable		 2zmaA-4pf8A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4pf8 TRAP-T FAMILY
TRANSPORTER, DCTP
(PERIPLASMIC
BINDING) SUBUNIT
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 GLU A  35
GLY A 140
THR A 263
HIS A  41
MET A  43
 None
 1.26A 5esgA-4pf8A:
undetectable		 5esgA-4pf8A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJS_A_SALA603_0
(VICILIN-LIKE
ANTIMICROBIAL
PEPTIDES 2-2)		 4pf8 TRAP-T FAMILY
TRANSPORTER, DCTP
(PERIPLASMIC
BINDING) SUBUNIT
(Sulfitobacter
sp.
NAS-14.1) 		5 / 11 MET A 178
VAL A 162
PHE A 149
MET A 182
GLY A 184
 None
 1.49A 5yjsA-4pf8A:
undetectable		 5yjsA-4pf8A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4pf8 TRAP-T FAMILY
TRANSPORTER, DCTP
(PERIPLASMIC
BINDING) SUBUNIT
(Sulfitobacter
sp.
NAS-14.1) 		4 / 6 MET A 119
ALA A 130
LEU A 131
ALA A 138
 None
 1.09A 6fosB-4pf8A:
undetectable		 6fosB-4pf8A:
13.62