SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pfb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN
(Fusobacterium
nucleatum) 		5 / 12 VAL A  44
GLY A  89
THR A  31
VAL A  29
LEU A  86
 None
 1.03A 1jg4A-4pfbA:
undetectable		 1jg4A-4pfbA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN
(Fusobacterium
nucleatum) 		4 / 8 PRO A 170
SER A 235
THR A  39
PHE A 145
 G3P  A 407 (-4.2A)
None
None
None
 1.22A 1p7lD-4pfbA:
undetectable		 1p7lD-4pfbA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN
(Fusobacterium
nucleatum) 		4 / 8 PRO A 170
SER A 235
THR A  39
PHE A 145
 G3P  A 407 (-4.2A)
None
None
None
 1.22A 1rg9D-4pfbA:
undetectable		 1rg9D-4pfbA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN
(Fusobacterium
nucleatum) 		4 / 5 MET A  75
ALA A  79
ILE A 136
ASP A  95
 None
 1.17A 1upfA-4pfbA:
undetectable		 1upfA-4pfbA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN
(Fusobacterium
nucleatum) 		5 / 12 ALA A 263
LEU A  43
VAL A  46
ILE A  85
LEU A  60
 None
 1.12A 2qk8A-4pfbA:
undetectable		 2qk8A-4pfbA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN
(Fusobacterium
nucleatum) 		5 / 12 VAL A  29
GLN A 251
ILE A  50
ASN A  51
SER A  54
 None
 1.22A 2vdyA-4pfbA:
undetectable		 2vdyA-4pfbA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN
(Fusobacterium
nucleatum) 		5 / 12 ALA A 263
LEU A  43
VAL A  46
ILE A  85
LEU A  60
 None
 1.19A 3datA-4pfbA:
undetectable		 3datA-4pfbA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN
(Fusobacterium
nucleatum) 		4 / 7 THR A  64
VAL A  29
THR A  31
VAL A  87
 IMD  A 406 ( 3.6A)
None
None
None
 0.62A 3em0B-4pfbA:
undetectable		 3em0B-4pfbA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN
(Fusobacterium
nucleatum) 		4 / 8 TYR A 191
TYR A 195
GLU A 151
ILE A  70
 G3P  A 407 (-3.4A)
None
None
None
 0.91A 3jz0B-4pfbA:
undetectable		 3jz0B-4pfbA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN
(Fusobacterium
nucleatum) 		5 / 11 LEU A 174
THR A 104
ASN A 101
GLY A  94
ASP A  95
 None
 1.25A 3sfuC-4pfbA:
undetectable		 3sfuC-4pfbA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN
(Fusobacterium
nucleatum) 		5 / 12 VAL A  29
GLN A 251
ILE A  50
ASN A  51
SER A  54
 None
 1.21A 4c49A-4pfbA:
undetectable		 4c49A-4pfbA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN
(Fusobacterium
nucleatum) 		4 / 5 VAL A 138
LEU A  93
ILE A 136
LEU A 132
 None
 0.76A 4mghA-4pfbA:
undetectable		 4mghA-4pfbA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN
(Fusobacterium
nucleatum) 		4 / 5 LEU A 141
TYR A 100
ALA A 131
ILE A 136
 None
 1.02A 4y03B-4pfbA:
undetectable		 4y03B-4pfbA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN
(Fusobacterium
nucleatum) 		5 / 10 GLY A 233
GLY A 146
GLY A 208
SER A 209
ILE A 210
 None
 0.93A 5aqfA-4pfbA:
undetectable		 5aqfA-4pfbA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN
(Fusobacterium
nucleatum) 		5 / 10 GLY A 233
GLY A 146
GLY A 208
SER A 209
ILE A 210
 None
 0.92A 5aqfC-4pfbA:
undetectable		 5aqfC-4pfbA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN
(Fusobacterium
nucleatum) 		5 / 10 GLY A 233
GLY A 146
GLY A 208
SER A 209
ILE A 210
 None
 0.94A 5aqyA-4pfbA:
undetectable		 5aqyA-4pfbA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN
(Fusobacterium
nucleatum) 		4 / 4 VAL A 222
GLU A 151
GLY A 205
LEU A 198
 None
 1.02A 5g5gC-4pfbA:
undetectable		 5g5gC-4pfbA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN
(Fusobacterium
nucleatum) 		4 / 7 HIS A 230
ILE A 179
VAL A 169
ARG A 148
 None
None
None
G3P  A 407 (-2.9A)
 1.29A 5kkzC-4pfbA:
undetectable
5kkzE-4pfbA:
undetectable		 5kkzC-4pfbA:
19.21
5kkzE-4pfbA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN
(Fusobacterium
nucleatum) 		4 / 7 ILE A 179
VAL A 169
ARG A 148
HIS A 230
 None
None
G3P  A 407 (-2.9A)
None
 1.26A 5kkzK-4pfbA:
undetectable
5kkzQ-4pfbA:
undetectable		 5kkzK-4pfbA:
20.48
5kkzQ-4pfbA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN
(Fusobacterium
nucleatum) 		4 / 7 HIS A 230
ILE A 179
VAL A 169
ARG A 148
 None
None
None
G3P  A 407 (-2.9A)
 1.32A 5kkzM-4pfbA:
undetectable
5kkzO-4pfbA:
undetectable		 5kkzM-4pfbA:
19.21
5kkzO-4pfbA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN
(Fusobacterium
nucleatum) 		4 / 6 MET A 319
ASN A 101
VAL A 103
LEU A 322
 None
 1.35A 5xdhA-4pfbA:
undetectable
5xdhC-4pfbA:
undetectable		 5xdhA-4pfbA:
17.83
5xdhC-4pfbA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN
(Fusobacterium
nucleatum) 		4 / 5 LEU A 198
VAL A 222
GLU A 151
LEU A 206
 None
 0.90A 5xooB-4pfbA:
undetectable		 5xooB-4pfbA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN
(Fusobacterium
nucleatum) 		4 / 8 GLN A  38
THR A  39
SER A 209
PHE A 112
 None
 0.98A 6eqpA-4pfbA:
undetectable		 6eqpA-4pfbA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_0
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN
(Fusobacterium
nucleatum) 		5 / 12 PRO A 170
ILE A  70
THR A 216
PHE A 145
PHE A  33
 G3P  A 407 (-4.2A)
None
G3P  A 407 ( 4.5A)
None
G3P  A 407 (-4.4A)
 1.45A 6hloA-4pfbA:
0.6		 6hloA-4pfbA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN
(Fusobacterium
nucleatum) 		5 / 12 PRO A 170
ILE A  70
THR A 216
PHE A 145
PHE A  33
 G3P  A 407 (-4.2A)
None
G3P  A 407 ( 4.5A)
None
G3P  A 407 (-4.4A)
 1.49A 6j20A-4pfbA:
undetectable		 6j20A-4pfbA:
20.52