SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pfe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJ6_A_AZMA400_1
(CARBONIC ANHYDRASE
XIV)		 4pfe GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Vicugna
pacos) 		5 / 10 HIS A 181
LEU A  53
LEU A  64
THR A  62
THR A  63
 None
None
CRO  A  66 ( 3.9A)
CRO  A  66 ( 4.7A)
None
 1.37A 1rj6A-4pfeA:
undetectable		 1rj6A-4pfeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJ6_B_AZMB401_1
(CARBONIC ANHYDRASE
XIV)		 4pfe GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Vicugna
pacos) 		5 / 10 HIS A 181
LEU A  53
LEU A  64
THR A  62
THR A  63
 None
None
CRO  A  66 ( 3.9A)
CRO  A  66 ( 4.7A)
None
 1.36A 1rj6B-4pfeA:
undetectable		 1rj6B-4pfeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 4pfe GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Vicugna
pacos) 		3 / 3 ASN A 170
LEU A 141
HIS A 169
 None
 0.82A 2q6fB-4pfeA:
undetectable		 2q6fB-4pfeA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 4pfe GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Vicugna
pacos) 		5 / 12 LEU A  44
LEU A  42
ILE A  14
ALA A  37
PHE A  71
 None
CRO  A  66 ( 4.8A)
None
None
None
 1.17A 2qb4A-4pfeA:
undetectable		 2qb4A-4pfeA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 4pfe GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Vicugna
pacos) 		5 / 9 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CRO  A  66 ( 4.9A)
CRO  A  66 ( 4.0A)
None
None
 1.23A 3t3rB-4pfeA:
undetectable		 3t3rB-4pfeA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 4pfe GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Vicugna
pacos) 		5 / 9 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CRO  A  66 ( 4.9A)
CRO  A  66 ( 4.0A)
None
None
 1.27A 3t3rC-4pfeA:
undetectable		 3t3rC-4pfeA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 4pfe GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Vicugna
pacos) 		5 / 10 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CRO  A  66 ( 4.9A)
CRO  A  66 ( 4.0A)
None
None
 1.21A 3t3rD-4pfeA:
undetectable		 3t3rD-4pfeA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0S_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 4pfe GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Vicugna
pacos) 		5 / 11 HIS A 181
LEU A  53
LEU A  64
THR A  62
THR A  63
 None
None
CRO  A  66 ( 3.9A)
CRO  A  66 ( 4.7A)
None
 1.28A 4k0sA-4pfeA:
undetectable		 4k0sA-4pfeA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4pfe GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Vicugna
pacos) 		6 / 12 ALA A 110
LEU A  64
ILE A  14
LEU A  42
TYR A  92
THR A 108
 None
CRO  A  66 ( 3.9A)
None
CRO  A  66 ( 4.8A)
None
None
 1.48A 4qi9A-4pfeA:
undetectable		 4qi9A-4pfeA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4pfe GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Vicugna
pacos) 		6 / 12 ALA A 110
LEU A  64
ILE A  14
LEU A  42
TYR A  92
THR A 108
 None
CRO  A  66 ( 3.9A)
None
CRO  A  66 ( 4.8A)
None
None
 1.44A 4x5iA-4pfeA:
undetectable		 4x5iA-4pfeA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 4pfe GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Vicugna
pacos) 		4 / 8 GLY A 134
ILE A 136
LYS A 131
ASP A 129
 None
 0.94A 6ag0A-4pfeA:
undetectable		 6ag0A-4pfeA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4pfe GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Vicugna
pacos) 		5 / 10 SER A  86
LEU A 201
SER A  72
ILE A 152
PRO A 196
 None
 1.49A 6dlzB-4pfeA:
undetectable
6dlzC-4pfeA:
undetectable		 6dlzB-4pfeA:
13.89
6dlzC-4pfeA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4pfe GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Vicugna
pacos) 		5 / 10 SER A  86
LEU A 201
SER A  72
ILE A 152
PRO A 196
 None
 1.49A 6dm1B-4pfeA:
undetectable
6dm1C-4pfeA:
undetectable		 6dm1B-4pfeA:
13.89
6dm1C-4pfeA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4pfe GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Vicugna
pacos) 		5 / 10 SER A  86
LEU A 201
SER A  72
ILE A 152
PRO A 196
 None
 1.47A 6dm2B-4pfeA:
undetectable
6dm2C-4pfeA:
undetectable		 6dm2B-4pfeA:
13.89
6dm2C-4pfeA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4pfe GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Vicugna
pacos) 		5 / 10 ILE A 152
PRO A 196
SER A  86
LEU A 201
SER A  72
 None
 1.48A 6dm2A-4pfeA:
undetectable
6dm2D-4pfeA:
undetectable		 6dm2A-4pfeA:
13.89
6dm2D-4pfeA:
13.89