SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pfi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4pfi TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 7 GLY A 340
THR A 336
PHE A 149
PHE A 163
 None
 1.17A 2qx4A-4pfiA:
undetectable
2qx4B-4pfiA:
undetectable		 2qx4A-4pfiA:
21.04
2qx4B-4pfiA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 4pfi TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 LEU A 219
PHE A 188
ASN A 175
LEU A 177
THR A 210
 None
 1.17A 2w3mB-4pfiA:
undetectable		 2w3mB-4pfiA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4pfi TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 5 THR A 190
PHE A 188
PHE A 183
TYR A 203
 None
 1.21A 3em0A-4pfiA:
undetectable		 3em0A-4pfiA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 4pfi TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 12 ILE A 146
ALA A 148
LEU A 139
ILE A 255
ARG A 253
 None
 1.32A 3ia4B-4pfiA:
undetectable		 3ia4B-4pfiA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 4pfi TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Marinobacter
hydrocarbonoclas
ticus) 		5 / 11 PHE A 163
PHE A 149
GLY A 121
LEU A 129
PHE A 145
 None
 0.90A 3t3rA-4pfiA:
undetectable		 3t3rA-4pfiA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 4pfi TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 5 THR A  46
ILE A  78
GLU A 272
PHE A  66
 None
 1.29A 4ac9C-4pfiA:
undetectable		 4ac9C-4pfiA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4pfi TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 5 THR A  46
ILE A  78
GLU A 272
PHE A  66
 None
 1.32A 4acaC-4pfiA:
undetectable		 4acaC-4pfiA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4pfi TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 5 THR A  46
ILE A  78
GLU A 272
PHE A  66
 None
 1.30A 4acbC-4pfiA:
undetectable		 4acbC-4pfiA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 4pfi TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT
(Marinobacter
hydrocarbonoclas
ticus) 		4 / 8 SER A 252
TYR A 203
SER A 193
ASN A 124
 None
 1.10A 5l1fA-4pfiA:
2.5
5l1fB-4pfiA:
4.3		 5l1fA-4pfiA:
16.81
5l1fB-4pfiA:
16.81