SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pfm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4pfm 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Shewanella
benthica) 		4 / 6 SER A 125
ALA A 123
THR A  89
ASN A  77
 None
 1.16A 1yvpB-4pfmA:
undetectable		 1yvpB-4pfmA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 4pfm 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Shewanella
benthica) 		6 / 12 ALA A 255
ILE A 262
GLY A 260
PRO A 211
VAL A 210
ILE A 209
 None
 1.49A 2bpxB-4pfmA:
undetectable		 2bpxB-4pfmA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 4pfm 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Shewanella
benthica) 		4 / 8 LEU A 239
ARG A 290
SER A   5
MET A 217
 None
 1.14A 2qd2A-4pfmA:
undetectable		 2qd2A-4pfmA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4pfm 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Shewanella
benthica) 		5 / 12 ILE A  74
ALA A  38
ASN A   3
ALA A   8
ILE A 158
 None
None
None
KPI  A 161 ( 3.4A)
None
 1.04A 3e00A-4pfmA:
undetectable		 3e00A-4pfmA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 4pfm 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Shewanella
benthica) 		5 / 10 ASP A 200
ARG A 174
PHE A 181
ILE A 131
ILE A   6
 None
 1.11A 3ihzA-4pfmA:
undetectable		 3ihzA-4pfmA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O5R_A_FK5A1001_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 4pfm 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Shewanella
benthica) 		5 / 11 ASP A 200
ARG A 174
PHE A 181
ILE A 131
ILE A   6
 None
 1.22A 3o5rA-4pfmA:
undetectable		 3o5rA-4pfmA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 4pfm 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Shewanella
benthica) 		5 / 12 ALA A 255
ALA A 289
LYS A 287
ALA A 285
ILE A 236
 None
 1.01A 3ut5D-4pfmA:
undetectable		 3ut5D-4pfmA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4pfm 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Shewanella
benthica) 		5 / 12 LEU A  95
ILE A 128
GLN A 130
HIS A  56
VAL A  19
 None
None
None
LYS  A 301 (-3.9A)
None
 1.36A 3w1wB-4pfmA:
2.0		 3w1wB-4pfmA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4pfm 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Shewanella
benthica) 		4 / 7 GLY A  76
GLY A 102
MET A 100
HIS A 118
 None
 0.92A 4c5nA-4pfmA:
2.1		 4c5nA-4pfmA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4pfm 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Shewanella
benthica) 		5 / 12 ASN A 156
ASP A 127
ILE A 128
ALA A  98
VAL A  97
 None
 1.18A 4dx5B-4pfmA:
undetectable		 4dx5B-4pfmA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4pfm 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Shewanella
benthica) 		5 / 12 ASN A 156
ASP A 127
ILE A 128
ALA A  98
VAL A  97
 None
 1.16A 4u8vB-4pfmA:
undetectable		 4u8vB-4pfmA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4pfm 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Shewanella
benthica) 		5 / 12 ASN A 156
ASP A 127
ILE A 128
ALA A  98
VAL A  97
 None
 1.17A 4u95B-4pfmA:
0.7		 4u95B-4pfmA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 4pfm 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Shewanella
benthica) 		5 / 12 LEU A 282
ALA A 289
LYS A 287
ALA A 285
ILE A 236
 None
 1.07A 4x1iD-4pfmA:
3.0		 4x1iD-4pfmA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4pfm 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Shewanella
benthica) 		5 / 12 LEU A 282
ALA A 289
LYS A 287
ALA A 285
ILE A 236
 None
 1.13A 4x1kD-4pfmA:
2.2		 4x1kD-4pfmA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4pfm 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Shewanella
benthica) 		5 / 12 LEU A 282
ALA A 289
LYS A 287
ALA A 285
ILE A 236
 None
 1.05A 4x1yD-4pfmA:
2.5		 4x1yD-4pfmA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4pfm 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Shewanella
benthica) 		4 / 6 PHE A 214
SER A 204
VAL A   7
ASP A  37
 None
 1.18A 5hesA-4pfmA:
undetectable		 5hesA-4pfmA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB7_A_PARA900_0
(AAC(3)-IIIB PROTEIN)		 4pfm 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Shewanella
benthica) 		5 / 10 ASN A 108
TYR A 119
HIS A 118
GLY A  78
GLU A  84
 None
None
None
None
LYS  A 302 (-2.9A)
 1.34A 6mb7A-4pfmA:
undetectable		 6mb7A-4pfmA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 4pfm 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Shewanella
benthica) 		6 / 12 PRO A  12
TRP A 254
LEU A 283
LEU A 261
GLY A 260
ILE A 209
 None
 1.35A 6qxsB-4pfmA:
undetectable		 6qxsB-4pfmA:
19.70