SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pfq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 4pfq HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Brachybacterium
faecium) 		4 / 5 ARG A 157
ALA A 154
ASP A 174
GLY A 172
 None
 1.01A 1e7bA-4pfqA:
undetectable		 1e7bA-4pfqA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 4pfq HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Brachybacterium
faecium) 		4 / 5 ARG A 157
ALA A 154
ASP A 174
GLY A 172
 None
 1.05A 1e7cA-4pfqA:
undetectable		 1e7cA-4pfqA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 4pfq HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Brachybacterium
faecium) 		5 / 11 SER A 104
LEU A 135
GLY A 132
LEU A 139
SER A 140
 None
 0.96A 2qmmA-4pfqA:
undetectable
2qmmB-4pfqA:
undetectable		 2qmmA-4pfqA:
24.79
2qmmB-4pfqA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 4pfq HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Brachybacterium
faecium) 		4 / 6 LEU A 135
GLY A 132
LEU A 139
SER A 140
 None
 0.64A 3aiaA-4pfqA:
undetectable		 3aiaA-4pfqA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 4pfq HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Brachybacterium
faecium) 		4 / 7 TYR A 191
GLU A 189
LEU A 194
ASN A 193
 None
 1.30A 3k8mB-4pfqA:
undetectable		 3k8mB-4pfqA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 4pfq HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Brachybacterium
faecium) 		5 / 10 ASP A  39
VAL A 197
ILE A  43
GLY A 172
ILE A 171
 None
 1.01A 3nujA-4pfqA:
undetectable		 3nujA-4pfqA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)		 4pfq HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Brachybacterium
faecium) 		5 / 12 ASP A  39
VAL A 197
ILE A  43
GLY A 172
ILE A 171
 None
 0.92A 4dqfA-4pfqA:
undetectable		 4dqfA-4pfqA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 4pfq HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Brachybacterium
faecium) 		4 / 4 ASP A 186
GLY A  71
ASP A 127
ASP A 130
 None
None
MG  A 400 (-2.6A)
None
 1.00A 5e72A-4pfqA:
undetectable		 5e72A-4pfqA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 4pfq HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Brachybacterium
faecium) 		5 / 9 ILE A 171
ALA A 154
LEU A  79
TYR A 183
ARG A 157
 None
 1.36A 6nm4B-4pfqA:
undetectable		 6nm4B-4pfqA:
21.33