SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pfr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 4pfr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		4 / 7 MET A 229
SER A 168
ALA A 173
ILE A 172
 None
MLT  A 401 ( 4.5A)
None
None
 0.92A 1fxhA-4pfrA:
undetectable
1fxhB-4pfrA:
1.0		 1fxhA-4pfrA:
23.32
1fxhB-4pfrA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 4pfr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		5 / 11 LEU A 138
ALA A 260
GLU A 259
LEU A  48
ILE A  26
 None
 1.27A 1g50A-4pfrA:
undetectable		 1g50A-4pfrA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 4pfr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		4 / 6 PRO A  94
ALA A  74
GLU A  85
GLU A  70
 None
 1.40A 1qhyA-4pfrA:
undetectable		 1qhyA-4pfrA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 4pfr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		5 / 11 ALA A  84
VAL A  59
GLY A 257
ALA A  57
ILE A  26
 None
 0.90A 2idwA-4pfrA:
undetectable		 2idwA-4pfrA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4pfr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		4 / 6 MET A 103
PRO A 105
ILE A 311
ASN A 170
 None
 0.88A 2wekB-4pfrA:
undetectable		 2wekB-4pfrA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4pfr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		4 / 8 GLY A 139
ILE A  61
VAL A  73
THR A  38
 None
 0.84A 2yoeB-4pfrA:
undetectable
2yoeC-4pfrA:
undetectable		 2yoeB-4pfrA:
21.11
2yoeC-4pfrA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)		 4pfr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		5 / 9 ALA A  84
VAL A  59
GLY A 257
ALA A  57
ILE A  26
 None
 1.08A 3ektB-4pfrA:
undetectable		 3ektB-4pfrA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 4pfr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		5 / 12 ALA A  84
VAL A  59
GLY A 257
LEU A 254
ILE A  26
 None
 0.98A 3em6B-4pfrA:
undetectable		 3em6B-4pfrA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 4pfr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		5 / 11 LEU A 140
LEU A 121
MET A 103
GLY A  90
LEU A  92
 None
 1.39A 3hm1B-4pfrA:
undetectable		 3hm1B-4pfrA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4pfr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		3 / 3 ASN A  65
ASP A  32
ARG A 166
 None
None
MLT  A 401 (-3.1A)
 0.56A 3k13A-4pfrA:
undetectable		 3k13A-4pfrA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 4pfr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		3 / 3 ARG A 265
ASP A 123
GLN A 251
 None
 0.79A 3lcvB-4pfrA:
undetectable		 3lcvB-4pfrA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4pfr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		4 / 4 LEU A 235
LEU A 254
GLN A  46
GLU A  83
 None
 1.11A 4i41A-4pfrA:
undetectable		 4i41A-4pfrA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4pfr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		4 / 8 PHE A  45
ALA A 137
LEU A 138
GLY A 257
 None
 0.85A 4xk8a-4pfrA:
undetectable		 4xk8a-4pfrA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 4pfr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		4 / 6 GLU A  34
HIS A  30
ALA A  42
GLN A  46
 None
 1.41A 6f6jC-4pfrA:
undetectable
6f6jD-4pfrA:
undetectable		 6f6jC-4pfrA:
23.59
6f6jD-4pfrA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 4pfr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		3 / 3 TRP A 316
GLU A 315
GLU A 322
 None
 1.02A 6fhwA-4pfrA:
undetectable		 6fhwA-4pfrA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_B_NMYB302_0
(AAC(3)-IIIB PROTEIN)		 4pfr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		5 / 10 ASP A 222
ASP A 292
THR A 156
GLY A 288
GLU A 293
 None
 1.48A 6mb9B-4pfrA:
undetectable		 6mb9B-4pfrA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_C_NMYC302_0
(AAC(3)-IIIB PROTEIN)		 4pfr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT
(Rhodobacter
sphaeroides) 		5 / 10 ASP A 222
ASP A 292
THR A 156
GLY A 288
GLU A 293
 None
 1.48A 6mb9C-4pfrA:
undetectable		 6mb9C-4pfrA:
14.65