SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pfs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 165
LEU A 169
GLY A 187
ALA A 188
LEU A 155
 None
 1.10A 2aylA-4pfsA:
undetectable		 2aylA-4pfsA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 VAL A 203
PHE A 268
PRO A 190
THR A 191
 None
 1.31A 2q6oB-4pfsA:
undetectable		 2q6oB-4pfsA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 VAL A 207
PHE A 268
PRO A 190
THR A 191
 None
 1.45A 2q6oB-4pfsA:
undetectable		 2q6oB-4pfsA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 183
ILE A 172
VAL A  12
THR A 141
PHE A 168
 None
 1.28A 2qo4A-4pfsA:
undetectable		 2qo4A-4pfsA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 183
ILE A 172
VAL A  12
THR A 141
PHE A 168
 None
 1.29A 2qo6A-4pfsA:
undetectable		 2qo6A-4pfsA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 LEU A  44
ASP A 150
VAL A  15
THR A  27
 None
 1.32A 3cyxB-4pfsA:
undetectable		 3cyxB-4pfsA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 VAL A 165
LEU A 169
GLY A 187
ALA A 188
LEU A 155
 None
 1.18A 3n8yA-4pfsA:
undetectable		 3n8yA-4pfsA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 165
LEU A 169
GLY A 187
ALA A 188
LEU A 155
 None
 1.08A 3nt1A-4pfsA:
undetectable		 3nt1A-4pfsA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 165
LEU A 169
GLY A 187
ALA A 188
LEU A 155
 None
 1.08A 3nt1B-4pfsA:
undetectable		 3nt1B-4pfsA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 PHE A 168
LEU A 145
THR A 146
LEU A 185
ILE A 172
 None
 1.18A 3tbgD-4pfsA:
undetectable		 3tbgD-4pfsA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 ALA A 188
PRO A 154
LEU A 185
LEU A 213
 None
 0.94A 4iomA-4pfsA:
11.3		 4iomA-4pfsA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 217
THR A  27
ILE A  31
LEU A  13
ILE A 152
 None
 1.10A 4kjkA-4pfsA:
3.5		 4kjkA-4pfsA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		6 / 12 ALA A 217
THR A  27
ILE A  31
LEU A  13
ILE A 152
THR A 267
 None
 1.41A 4kjlA-4pfsA:
2.7		 4kjlA-4pfsA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 MET A  89
GLU A  87
GLU A  37
ARG A 249
 None
 0.83A 4mj8B-4pfsA:
undetectable
4mj8C-4pfsA:
undetectable		 4mj8B-4pfsA:
19.93
4mj8C-4pfsA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 217
THR A  27
ILE A  31
LEU A  13
ILE A 152
 None
 1.13A 4nx7A-4pfsA:
3.3		 4nx7A-4pfsA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 165
LEU A 169
GLY A 187
ALA A 188
LEU A 155
 None
 1.14A 4rrwA-4pfsA:
undetectable		 4rrwA-4pfsA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 165
LEU A 169
GLY A 187
ALA A 188
LEU A 155
 None
 1.13A 4rrwB-4pfsA:
undetectable		 4rrwB-4pfsA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 165
LEU A 169
GLY A 187
ALA A 188
LEU A 155
 None
 1.14A 4rrzA-4pfsA:
undetectable		 4rrzA-4pfsA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 165
LEU A 169
GLY A 187
ALA A 188
LEU A 155
 None
 1.13A 4rrzB-4pfsA:
undetectable		 4rrzB-4pfsA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 186
TRP A 259
LEU A  13
MET A  89
LEU A  35
 None
 1.13A 4xi3D-4pfsA:
undetectable		 4xi3D-4pfsA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 165
LEU A 169
GLY A 187
ALA A 188
LEU A 155
 None
 1.14A 5ikrA-4pfsA:
undetectable		 5ikrA-4pfsA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 THR A  27
THR A  26
THR A  25
GLY A  32
MET A  89
 None
 1.40A 5lf3b-4pfsA:
undetectable		 5lf3b-4pfsA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 THR A  27
THR A  26
THR A  25
GLY A  32
MET A  89
 None
 1.40A 5lf3N-4pfsA:
undetectable		 5lf3N-4pfsA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		6 / 12 VAL A  76
ASP A  75
GLU A  70
LEU A  82
ALA A  81
LEU A  98
 None
 1.38A 5nd4B-4pfsA:
3.7		 5nd4B-4pfsA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		6 / 12 ALA A 217
THR A  27
ILE A  31
LEU A  13
ILE A 152
THR A 267
 None
 1.38A 5z6jA-4pfsA:
3.3		 5z6jA-4pfsA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 MET A 265
ASP A 150
ARG A  40
 None
 1.20A 5z6jA-4pfsA:
3.3		 5z6jA-4pfsA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		6 / 12 ALA A 217
THR A  27
ILE A  31
LEU A  13
ILE A 152
THR A 267
 None
 1.36A 5z6kA-4pfsA:
3.1		 5z6kA-4pfsA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 4pfs COBYRINIC ACID
A,C-DIAMIDE SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A  45
LEU A  47
LEU A 122
LEU A  72
LEU A 115
 None
 0.98A 6f6iA-4pfsA:
undetectable
6f6iB-4pfsA:
undetectable		 6f6iA-4pfsA:
15.44
6f6iB-4pfsA:
17.94