SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pfy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 8 LEU A  75
GLY A 210
TRP A  97
GLU A  59
 None
 0.76A 1jlfA-4pfyA:
undetectable
1jlfB-4pfyA:
2.2		 1jlfA-4pfyA:
22.26
1jlfB-4pfyA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 LEU A 401
VAL A 404
GLY A 405
ILE A 354
 None
 0.74A 1p2yA-4pfyA:
undetectable		 1p2yA-4pfyA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		3 / 3 GLU A 152
TRP A 129
LYS A 502
 BMA  A 603 ( 3.2A)
BMA  A 603 ( 4.2A)
None
 1.39A 1qu2A-4pfyA:
undetectable		 1qu2A-4pfyA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 ALA A 299
ARG A 296
ASP A 347
TYR A 300
 None
 1.26A 2e5dA-4pfyA:
undetectable
2e5dB-4pfyA:
undetectable		 2e5dA-4pfyA:
24.83
2e5dB-4pfyA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 11 LEU A 429
ILE A 280
ILE A 302
LEU A 401
VAL A 408
 None
 1.04A 2kawA-4pfyA:
undetectable		 2kawA-4pfyA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 5 ILE A 381
LEU A 429
ALA A 398
PHE A 294
 None
 1.02A 2opxA-4pfyA:
undetectable		 2opxA-4pfyA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 6 TYR A 418
ALA A 419
LEU A 422
ASN A 276
 None
None
None
BMA  A 607 ( 4.9A)
 0.81A 3b6hA-4pfyA:
undetectable		 3b6hA-4pfyA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 6 TYR A 418
ALA A 419
LEU A 422
ASN A 276
 None
None
None
BMA  A 607 ( 4.9A)
 0.81A 3b6hB-4pfyA:
undetectable		 3b6hB-4pfyA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 THR A 436
ILE A 394
ILE A 397
LEU A 422
TYR A 418
 None
 1.22A 3gwxA-4pfyA:
undetectable		 3gwxA-4pfyA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 TYR A  29
TRP A 523
GLY A 236
ALA A 234
ILE A 223
 None
 1.33A 3ld6A-4pfyA:
undetectable		 3ld6A-4pfyA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_B_GLYB509_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 4 PHE A 434
THR A 435
LEU A 422
TYR A 423
 BMA  A 606 ( 3.5A)
BMA  A 605 ( 4.7A)
None
BMA  A 605 ( 4.9A)
 1.32A 3pgyB-4pfyA:
undetectable		 3pgyB-4pfyA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQ4_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H2)		 4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 TYR A 418
SER A 460
ASN A 432
PHE A 427
GLU A 382
 None
 1.32A 3rq4A-4pfyA:
undetectable		 3rq4A-4pfyA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 VAL A 535
VAL A 438
LEU A 325
GLY A 513
ALA A 514
 None
 1.07A 3rr3C-4pfyA:
undetectable		 3rr3C-4pfyA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 VAL A 535
VAL A 438
LEU A 325
GLY A 513
ALA A 514
 None
 1.07A 3rr3D-4pfyA:
undetectable		 3rr3D-4pfyA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 5 PHE A 344
ALA A 319
THR A 277
LEU A 500
 None
 1.17A 3t3zC-4pfyA:
undetectable		 3t3zC-4pfyA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 6 TYR A 287
PHE A 360
PRO A 372
LEU A 358
 None
 1.18A 3tgvB-4pfyA:
undetectable		 3tgvB-4pfyA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_C_BEZC1_0
(HEME-BINDING PROTEIN
HUTZ)		 4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 5 TYR A 287
PHE A 360
PRO A 372
LEU A 358
 None
 1.14A 3tgvC-4pfyA:
undetectable		 3tgvC-4pfyA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 6 TYR A 287
PHE A 360
PRO A 372
LEU A 358
 None
 1.16A 3tgvD-4pfyA:
undetectable		 3tgvD-4pfyA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIS_A_DAHA24_1
(POLYSACCHARIDE
MONOOXYGENASE-3)		 4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 5 TYR A 511
PRO A 274
MET A 272
PRO A 270
 None
 1.27A 4eisA-4pfyA:
0.0
4eisB-4pfyA:
0.0		 4eisA-4pfyA:
16.86
4eisB-4pfyA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 8 ILE A 554
PHE A 516
TRP A 265
GLY A 547
ASN A 247
 None
 1.47A 4fgjA-4pfyA:
undetectable
4fgjB-4pfyA:
undetectable		 4fgjA-4pfyA:
18.28
4fgjB-4pfyA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 8 PRO A 125
VAL A 126
ILE A 121
MET A 156
 BMA  A 603 ( 4.2A)
BMA  A 603 ( 4.6A)
None
BMA  A 603 ( 3.8A)
 1.07A 4iilA-4pfyA:
2.4		 4iilA-4pfyA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 4 ASN A 181
VAL A 163
THR A  53
ILE A  54
 None
 1.01A 4retA-4pfyA:
undetectable		 4retA-4pfyA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 4 ASN A 181
VAL A 163
THR A  53
ILE A  54
 None
 1.01A 4retC-4pfyA:
undetectable		 4retC-4pfyA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 LEU A 401
ILE A 507
ILE A 406
ALA A 297
PHE A 294
 None
 1.14A 4rp8C-4pfyA:
undetectable		 4rp8C-4pfyA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		3 / 3 ASP A 414
GLU A 382
SER A  39
 None
 0.82A 5bw4B-4pfyA:
undetectable		 5bw4B-4pfyA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 6 GLU A 169
PHE A 110
GLU A 175
VAL A 176
 None
 0.98A 5h4dA-4pfyA:
undetectable		 5h4dA-4pfyA:
19.27