SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pfz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 4pfz 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 TRP A 230
VAL A 104
PRO A 103
 None
 0.95A 1rg1A-4pfzA:
undetectable		 1rg1A-4pfzA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 4pfz 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 TRP A 230
VAL A 104
PRO A 103
 None
 0.95A 1rh0A-4pfzA:
undetectable		 1rh0A-4pfzA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4pfz 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 189
ALA A  74
THR A 269
VAL A 264
ALA A 136
 None
 1.23A 1vq1A-4pfzA:
undetectable		 1vq1A-4pfzA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4pfz 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 ILE A 139
GLY A 140
PHE A  55
ILE A  76
 None
 0.87A 2y7wC-4pfzA:
undetectable		 2y7wC-4pfzA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4pfz 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLY A 133
ILE A 224
VAL A 193
THR A 217
 None
 0.85A 2yoeB-4pfzA:
undetectable
2yoeC-4pfzA:
undetectable		 2yoeB-4pfzA:
21.07
2yoeC-4pfzA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 4pfz 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ASP A 163
LYS A 180
GLY A 246
GLU A 134
 NA  A 301 (-3.4A)
NA  A 301 ( 4.0A)
NA  A 301 ( 4.4A)
NA  A 301 (-2.8A)
 0.94A 2ys6A-4pfzA:
undetectable		 2ys6A-4pfzA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4pfz 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 LEU A 270
ALA A 112
VAL A 164
LEU A 122
THR A 271
 None
 1.21A 3jwqB-4pfzA:
undetectable
3jwqC-4pfzA:
undetectable		 3jwqB-4pfzA:
21.62
3jwqC-4pfzA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 4pfz 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 HIS A 130
HIS A 131
ILE A 254
 None
 0.85A 3u52A-4pfzA:
undetectable
3u52C-4pfzA:
undetectable		 3u52A-4pfzA:
19.09
3u52C-4pfzA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4pfz 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 267
VAL A 201
ILE A 224
LEU A 227
VAL A  84
 None
 1.06A 3w67C-4pfzA:
undetectable		 3w67C-4pfzA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4pfz 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 267
VAL A 201
ILE A 224
LEU A 227
VAL A  84
 None
 1.02A 3w68B-4pfzA:
undetectable		 3w68B-4pfzA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 4pfz 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 HIS A 130
GLU A 132
GLN A 213
GLY A 250
 None
NA  A 301 (-4.0A)
None
None
 1.01A 4f93B-4pfzA:
undetectable		 4f93B-4pfzA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 4pfz 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 CYH A 186
LEU A 244
LEU A 188
ALA A 136
 None
 1.13A 5hpuA-4pfzA:
undetectable
5hpuB-4pfzA:
undetectable		 5hpuA-4pfzA:
13.43
5hpuB-4pfzA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 4pfz 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A  72
THR A 269
THR A 263
LEU A  67
 None
 1.05A 5jq7B-4pfzA:
undetectable		 5jq7B-4pfzA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4pfz 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 192
THR A 159
THR A 245
VAL A  84
VAL A 201
 None
 1.20A 6bzoC-4pfzA:
undetectable		 6bzoC-4pfzA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4pfz 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A 122
ASP A 125
ARG A 276
GLN A 169
 None
 1.37A 6g31D-4pfzA:
undetectable		 6g31D-4pfzA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 4pfz 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 LEU A  24
THR A 194
THR A 159
GLY A 157
 None
 1.14A 6gtqA-4pfzA:
undetectable		 6gtqA-4pfzA:
20.69