SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pg6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 4pg6 HOMOSERINE
DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 12 HIS A  59
ILE A  67
LEU A  90
LEU A   8
GLY A  10
 None
None
None
None
DMS  A 511 (-3.2A)
 1.02A 1axwA-4pg6A:
undetectable		 1axwA-4pg6A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4pg6 HOMOSERINE
DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 11 LEU A   8
GLU A  23
VAL A  19
ILE A  22
LEU A  73
 None
 1.36A 1mrqA-4pg6A:
undetectable		 1mrqA-4pg6A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4pg6 HOMOSERINE
DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 12 HIS A  59
ILE A  67
LEU A  90
LEU A   8
GLY A  10
 None
None
None
None
DMS  A 511 (-3.2A)
 1.07A 1tlsA-4pg6A:
undetectable		 1tlsA-4pg6A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 4pg6 HOMOSERINE
DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 12 HIS A  59
ILE A  67
LEU A  90
LEU A   8
GLY A  10
 None
None
None
None
DMS  A 511 (-3.2A)
 1.10A 1tlsB-4pg6A:
undetectable		 1tlsB-4pg6A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4pg6 HOMOSERINE
DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 12 HIS A  59
ILE A  67
LEU A  90
LEU A   8
GLY A  10
 None
None
None
None
DMS  A 511 (-3.2A)
 1.06A 1tsnA-4pg6A:
undetectable		 1tsnA-4pg6A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4pg6 HOMOSERINE
DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 9 LEU A   9
LEU A   8
LEU A  43
LEU A  73
ILE A  76
 None
 1.05A 2f7aB-4pg6A:
undetectable		 2f7aB-4pg6A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 4pg6 HOMOSERINE
DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 11 GLY A 199
SER A 162
ILE A 157
PRO A 265
ILE A 246
 None
 1.01A 2nnhA-4pg6A:
undetectable		 2nnhA-4pg6A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4pg6 HOMOSERINE
DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 12 VAL A  77
ILE A  83
ASP A 106
LEU A 115
LEU A 114
 None
 0.98A 3cjtC-4pg6A:
2.1		 3cjtC-4pg6A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 4pg6 HOMOSERINE
DEHYDROGENASE
(Staphylococcus
aureus) 		3 / 3 PHE A 381
LYS A 354
SER A 355
 None
 1.24A 3tyeB-4pg6A:
undetectable		 3tyeB-4pg6A:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 4pg6 HOMOSERINE
DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 12 HIS A  59
ILE A  67
LEU A  90
LEU A   8
GLY A  10
 None
None
None
None
DMS  A 511 (-3.2A)
 1.14A 4foxA-4pg6A:
undetectable		 4foxA-4pg6A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 4pg6 HOMOSERINE
DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 12 HIS A  59
ILE A  67
LEU A  90
LEU A   8
GLY A  10
 None
None
None
None
DMS  A 511 (-3.2A)
 1.11A 4foxG-4pg6A:
undetectable		 4foxG-4pg6A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 4pg6 HOMOSERINE
DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 9 LEU A 158
GLY A 156
ILE A 208
SER A 213
LEU A 212
 None
 1.18A 4x3mB-4pg6A:
4.4		 4x3mB-4pg6A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 4pg6 HOMOSERINE
DEHYDROGENASE
(Staphylococcus
aureus) 		4 / 6 LYS A 184
LEU A 180
ALA A 189
SER A 162
 None
 0.99A 5l4iA-4pg6A:
undetectable		 5l4iA-4pg6A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4pg6 HOMOSERINE
DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 10 LEU A   8
VAL A  14
VAL A 311
GLY A 307
LEU A  11
 None
ACT  A 503 ( 4.9A)
None
None
DMS  A 511 (-4.8A)
 1.50A 6bsgA-4pg6A:
undetectable		 6bsgA-4pg6A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4pg6 HOMOSERINE
DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 10 LEU A   8
VAL A  14
VAL A 311
GLY A 307
LEU A  11
 None
ACT  A 503 ( 4.9A)
None
None
DMS  A 511 (-4.8A)
 1.48A 6bsjA-4pg6A:
undetectable		 6bsjA-4pg6A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 4pg6 HOMOSERINE
DEHYDROGENASE
(Staphylococcus
aureus) 		5 / 12 GLY A 307
ILE A  22
VAL A  77
LEU A   8
ILE A   6
 None
 1.03A 6ectA-4pg6A:
3.8		 6ectA-4pg6A:
23.41