SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pgh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		6 / 10 GLY A 206
ASP A 229
LEU A 230
VAL A 233
ASP A 249
TRP A 269
 SAM  A 401 (-3.8A)
SAM  A 401 (-2.6A)
SAM  A 401 (-4.3A)
SAM  A 401 ( 4.9A)
SAM  A 401 (-3.2A)
None
 0.34A 1fpqA-4pghA:
26.8		 1fpqA-4pghA:
38.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD6_0
(GRAMICIDIN A)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		4 / 4 VAL A 312
TRP A 356
ALA A 355
VAL A 298
 None
 1.49A 1gmkC-4pghA:
undetectable
1gmkD-4pghA:
undetectable		 1gmkC-4pghA:
4.94
1gmkD-4pghA:
4.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		4 / 6 SER A 181
GLY A 208
THR A 212
ILE A 209
 SAM  A 401 (-3.6A)
SAM  A 401 ( 4.1A)
SAM  A 401 (-4.1A)
None
 0.92A 1gtnD-4pghA:
undetectable
1gtnE-4pghA:
undetectable		 1gtnD-4pghA:
12.97
1gtnE-4pghA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		3 / 3 ASN A 323
ALA A 159
ASN A 152
 None
 0.80A 1n4fA-4pghA:
undetectable		 1n4fA-4pghA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		6 / 12 GLY A 206
GLY A 207
GLY A 208
LEU A 230
ASP A 249
TRP A 269
 SAM  A 401 (-3.8A)
SAM  A 401 ( 3.9A)
SAM  A 401 ( 4.1A)
SAM  A 401 (-4.3A)
SAM  A 401 (-3.2A)
None
 0.55A 1qzzA-4pghA:
19.9		 1qzzA-4pghA:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		5 / 9 PHE A 360
VAL A 294
LEU A 266
PHE A 346
LEU A 278
 None
 1.40A 1wrkA-4pghA:
undetectable
1wrkB-4pghA:
undetectable		 1wrkA-4pghA:
16.48
1wrkB-4pghA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		6 / 12 GLY A 206
GLY A 207
GLY A 208
LEU A 230
ASP A 249
TRP A 269
 SAM  A 401 (-3.8A)
SAM  A 401 ( 3.9A)
SAM  A 401 ( 4.1A)
SAM  A 401 (-4.3A)
SAM  A 401 (-3.2A)
None
 0.41A 1xdsA-4pghA:
25.0		 1xdsA-4pghA:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		6 / 12 GLY A 206
GLY A 207
GLY A 208
LEU A 230
ASP A 249
TRP A 269
 SAM  A 401 (-3.8A)
SAM  A 401 ( 3.9A)
SAM  A 401 ( 4.1A)
SAM  A 401 (-4.3A)
SAM  A 401 (-3.2A)
None
 0.42A 1xdsB-4pghA:
24.8		 1xdsB-4pghA:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		4 / 8 MET A 317
PRO A 150
SER A 136
VAL A 144
 None
 1.10A 2qd2A-4pghA:
2.3		 2qd2A-4pghA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		5 / 12 GLY A 207
GLY A 208
LEU A 230
ASP A 268
TRP A 269
 SAM  A 401 ( 3.9A)
SAM  A 401 ( 4.1A)
SAM  A 401 (-4.3A)
None
None
 0.62A 3i5uA-4pghA:
25.5		 3i5uA-4pghA:
29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		5 / 12 GLY A 207
GLY A 208
LEU A 230
ASP A 268
TRP A 269
 SAM  A 401 ( 3.9A)
SAM  A 401 ( 4.1A)
SAM  A 401 (-4.3A)
None
None
 0.59A 3i5uB-4pghA:
25.6		 3i5uB-4pghA:
29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		5 / 12 GLY A 206
GLY A 208
GLY A 210
THR A 212
ASP A 249
 SAM  A 401 (-3.8A)
SAM  A 401 ( 4.1A)
None
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
 0.95A 3ihtA-4pghA:
8.9		 3ihtA-4pghA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		3 / 3 GLY A 208
ASP A 229
ASP A 249
 SAM  A 401 ( 4.1A)
SAM  A 401 (-2.6A)
SAM  A 401 (-3.2A)
 0.47A 3ou7C-4pghA:
15.4		 3ou7C-4pghA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		5 / 12 ASP A 283
ILE A 260
VAL A 254
VAL A 294
VAL A 292
 None
 0.90A 3ucbB-4pghA:
undetectable		 3ucbB-4pghA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		5 / 12 GLY A 206
GLY A 208
VAL A 233
ASP A 268
TRP A 269
 SAM  A 401 (-3.8A)
SAM  A 401 ( 4.1A)
SAM  A 401 ( 4.9A)
None
None
 0.63A 4a6eA-4pghA:
30.7		 4a6eA-4pghA:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		5 / 12 GLY A 208
GLY A 207
GLY A 206
HIS A 245
VAL A 233
 SAM  A 401 ( 4.1A)
SAM  A 401 ( 3.9A)
SAM  A 401 (-3.8A)
None
SAM  A 401 ( 4.9A)
 0.92A 4htfA-4pghA:
15.3		 4htfA-4pghA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		4 / 7 MET A 317
PRO A 150
SER A 136
VAL A 144
 None
 1.11A 4kmmA-4pghA:
undetectable		 4kmmA-4pghA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		3 / 3 ARG A 332
GLU A 331
PHE A 346
 None
 0.99A 4kszA-4pghA:
undetectable		 4kszA-4pghA:
20.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		11 / 11 SER A 181
GLY A 206
GLY A 207
THR A 212
ASP A 229
LEU A 230
VAL A 233
ASP A 249
MET A 250
LYS A 263
ILE A 265
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.8A)
SAM  A 401 ( 3.9A)
SAM  A 401 (-4.1A)
SAM  A 401 (-2.6A)
SAM  A 401 (-4.3A)
SAM  A 401 ( 4.9A)
SAM  A 401 (-3.2A)
SAM  A 401 (-3.7A)
SAM  A 401 (-2.4A)
None
 0.00A 4pghA-4pghA:
53.3		 4pghA-4pghA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		7 / 11 SER A 181
GLY A 208
THR A 212
ASP A 229
LEU A 230
ASP A 249
MET A 250
 SAM  A 401 (-3.6A)
SAM  A 401 ( 4.1A)
SAM  A 401 (-4.1A)
SAM  A 401 (-2.6A)
SAM  A 401 (-4.3A)
SAM  A 401 (-3.2A)
SAM  A 401 (-3.7A)
 1.13A 4pghA-4pghA:
53.3		 4pghA-4pghA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		12 / 12 SER A 181
ASP A 204
GLY A 206
THR A 212
ASP A 229
LEU A 230
ASP A 249
MET A 250
LYS A 263
ILE A 265
ASP A 268
TRP A 269
 SAM  A 401 (-3.6A)
SAM  A 401 ( 4.3A)
SAM  A 401 (-3.8A)
SAM  A 401 (-4.1A)
SAM  A 401 (-2.6A)
SAM  A 401 (-4.3A)
SAM  A 401 (-3.2A)
SAM  A 401 (-3.7A)
SAM  A 401 (-2.4A)
None
None
None
 0.34A 4pghB-4pghA:
49.1		 4pghB-4pghA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		5 / 11 GLY A 207
ASP A 229
VAL A 233
LYS A 263
TRP A 264
 SAM  A 401 ( 3.9A)
SAM  A 401 (-2.6A)
SAM  A 401 ( 4.9A)
SAM  A 401 (-2.4A)
None
 1.26A 4pghC-4pghA:
50.1		 4pghC-4pghA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		11 / 11 SER A 181
GLY A 206
ASP A 229
LEU A 230
VAL A 233
ASP A 249
MET A 250
LYS A 263
TRP A 264
ILE A 265
TRP A 269
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.8A)
SAM  A 401 (-2.6A)
SAM  A 401 (-4.3A)
SAM  A 401 ( 4.9A)
SAM  A 401 (-3.2A)
SAM  A 401 (-3.7A)
SAM  A 401 (-2.4A)
None
None
None
 0.18A 4pghC-4pghA:
50.1		 4pghC-4pghA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		9 / 12 SER A 181
GLY A 206
GLY A 207
THR A 212
ASP A 229
LEU A 230
ASP A 249
PHE A 251
LYS A 263
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.8A)
SAM  A 401 ( 3.9A)
SAM  A 401 (-4.1A)
SAM  A 401 (-2.6A)
SAM  A 401 (-4.3A)
SAM  A 401 (-3.2A)
SAM  A 401 ( 4.8A)
SAM  A 401 (-2.4A)
 0.79A 4pghD-4pghA:
38.4		 4pghD-4pghA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		11 / 12 SER A 181
GLY A 206
GLY A 207
THR A 212
ASP A 229
LEU A 230
MET A 250
PHE A 251
LYS A 263
ILE A 265
TRP A 269
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.8A)
SAM  A 401 ( 3.9A)
SAM  A 401 (-4.1A)
SAM  A 401 (-2.6A)
SAM  A 401 (-4.3A)
SAM  A 401 (-3.7A)
SAM  A 401 ( 4.8A)
SAM  A 401 (-2.4A)
None
None
 0.64A 4pghD-4pghA:
38.4		 4pghD-4pghA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		7 / 12 SER A 181
GLY A 208
THR A 212
ASP A 229
LEU A 230
ASP A 249
PHE A 251
 SAM  A 401 (-3.6A)
SAM  A 401 ( 4.1A)
SAM  A 401 (-4.1A)
SAM  A 401 (-2.6A)
SAM  A 401 (-4.3A)
SAM  A 401 (-3.2A)
SAM  A 401 ( 4.8A)
 1.40A 4pghD-4pghA:
38.4		 4pghD-4pghA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		8 / 12 SER A 181
GLY A 208
THR A 212
ASP A 229
LEU A 230
MET A 250
PHE A 251
TRP A 269
 SAM  A 401 (-3.6A)
SAM  A 401 ( 4.1A)
SAM  A 401 (-4.1A)
SAM  A 401 (-2.6A)
SAM  A 401 (-4.3A)
SAM  A 401 (-3.7A)
SAM  A 401 ( 4.8A)
None
 1.24A 4pghD-4pghA:
38.4		 4pghD-4pghA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		5 / 12 VAL A 298
GLU A 331
PHE A 360
LEU A 278
ARG A 332
 None
 1.37A 5hnxB-4pghA:
undetectable		 5hnxB-4pghA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		5 / 10 LEU A 112
PRO A 114
GLU A  38
GLY A  40
ALA A 125
 None
 1.17A 5o96E-4pghA:
undetectable
5o96F-4pghA:
undetectable		 5o96E-4pghA:
19.78
5o96F-4pghA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		5 / 12 GLY A 207
LEU A 230
VAL A 233
ASP A 268
TRP A 269
 SAM  A 401 ( 3.9A)
SAM  A 401 (-4.3A)
SAM  A 401 ( 4.9A)
None
None
 0.64A 5w7pA-4pghA:
24.7		 5w7pA-4pghA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		3 / 3 TYR A 162
HIS A 163
PHE A 169
 None
 0.97A 6esmA-4pghA:
undetectable		 6esmA-4pghA:
12.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		11 / 11 SER A 181
GLY A 206
GLY A 208
ASP A 229
LEU A 230
VAL A 233
ASP A 249
MET A 250
LYS A 263
TRP A 264
ASP A 268
 SAM  A 401 (-3.6A)
SAM  A 401 (-3.8A)
SAM  A 401 ( 4.1A)
SAM  A 401 (-2.6A)
SAM  A 401 (-4.3A)
SAM  A 401 ( 4.9A)
SAM  A 401 (-3.2A)
SAM  A 401 (-3.7A)
SAM  A 401 (-2.4A)
None
None
 0.66A 6i5zD-4pghA:
33.3		 6i5zD-4pghA:
39.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 4pgh CAFFEIC ACID
O-METHYLTRANSFERASE
(Sorghum
bicolor) 		9 / 11 SER A 181
GLY A 207
ASP A 229
LEU A 230
ASP A 249
MET A 250
LYS A 263
TRP A 264
ASP A 268
 SAM  A 401 (-3.6A)
SAM  A 401 ( 3.9A)
SAM  A 401 (-2.6A)
SAM  A 401 (-4.3A)
SAM  A 401 (-3.2A)
SAM  A 401 (-3.7A)
SAM  A 401 (-2.4A)
None
None
 0.98A 6i5zD-4pghA:
33.3		 6i5zD-4pghA:
39.19