SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pgw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4pgw UNCHARACTERIZED
PROTEIN YETJ
(Bacillus
subtilis) 		3 / 3 GLU A  99
TYR A  95
PHE A 207
 None
 0.80A 1eqbB-4pgwA:
undetectable		 1eqbB-4pgwA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4pgw UNCHARACTERIZED
PROTEIN YETJ
(Bacillus
subtilis) 		3 / 3 GLU A  99
TYR A  95
PHE A 207
 None
 0.80A 1eqbA-4pgwA:
undetectable		 1eqbA-4pgwA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4pgw UNCHARACTERIZED
PROTEIN YETJ
(Bacillus
subtilis) 		3 / 3 GLU A  99
TYR A  95
PHE A 207
 None
 0.80A 1eqbD-4pgwA:
undetectable		 1eqbD-4pgwA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4pgw UNCHARACTERIZED
PROTEIN YETJ
(Bacillus
subtilis) 		3 / 3 GLU A  99
TYR A  95
PHE A 207
 None
 0.81A 1eqbC-4pgwA:
undetectable		 1eqbC-4pgwA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4pgw UNCHARACTERIZED
PROTEIN YETJ
(Bacillus
subtilis) 		5 / 12 ILE A 185
LEU A 172
PHE A  20
LEU A  17
ILE A  16
 None
 0.98A 1g5yB-4pgwA:
undetectable		 1g5yB-4pgwA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 4pgw UNCHARACTERIZED
PROTEIN YETJ
(Bacillus
subtilis) 		5 / 12 LEU A 204
LEU A  81
ALA A  74
ALA A  27
VAL A  85
 None
 1.08A 1rbpA-4pgwA:
undetectable		 1rbpA-4pgwA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 4pgw UNCHARACTERIZED
PROTEIN YETJ
(Bacillus
subtilis) 		4 / 8 PHE A 124
SER A 123
LEU A 122
LYS A 119
 None
 0.91A 1sbrA-4pgwA:
undetectable		 1sbrA-4pgwA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4pgw UNCHARACTERIZED
PROTEIN YETJ
(Bacillus
subtilis) 		4 / 7 GLY A 112
GLY A 102
PHE A 196
PHE A  20
 None
 0.98A 2qwxA-4pgwA:
undetectable
2qwxB-4pgwA:
undetectable		 2qwxA-4pgwA:
23.11
2qwxB-4pgwA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4pgw UNCHARACTERIZED
PROTEIN YETJ
(Bacillus
subtilis) 		4 / 4 PHE A 108
TYR A 193
ILE A 162
LEU A 166
 None
 1.38A 3sudA-4pgwA:
undetectable		 3sudA-4pgwA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4pgw UNCHARACTERIZED
PROTEIN YETJ
(Bacillus
subtilis) 		4 / 5 VAL A 187
LEU A 190
SER A 191
MET A  52
 None
None
PT  A 301 ( 4.9A)
None
 1.36A 4e1gA-4pgwA:
undetectable		 4e1gA-4pgwA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 4pgw UNCHARACTERIZED
PROTEIN YETJ
(Bacillus
subtilis) 		4 / 7 LEU A  81
THR A  23
ALA A  27
LEU A  31
 None
 1.04A 5bojB-4pgwA:
undetectable		 5bojB-4pgwA:
22.33