SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pgz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 4pgz MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT
(Homo
sapiens) 		5 / 9 GLU C 338
ILE C 371
ASP C 398
GLY C 311
PHE C 312
 None
 1.46A 1i00A-4pgzC:
undetectable		 1i00A-4pgzC:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4pgz MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT
(Homo
sapiens) 		4 / 7 VAL C 409
VAL C 497
PRO C 434
GLY C 432
 None
 0.96A 5x80C-4pgzC:
undetectable
5x80D-4pgzC:
undetectable		 5x80C-4pgzC:
20.55
5x80D-4pgzC:
20.55