SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ph6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 4ph6 3-DEHYDROQUINATE
DEHYDRATASE
(Enterococcus
faecalis) 		4 / 7 GLN A 151
GLU A 152
MET A 191
PHE A 118
 None
 1.08A 1linA-4ph6A:
undetectable		 1linA-4ph6A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4ph6 3-DEHYDROQUINATE
DEHYDRATASE
(Enterococcus
faecalis) 		5 / 12 ALA A 222
VAL A 139
PHE A 225
GLY A  12
ILE A  11
 None
 1.32A 2dcfA-4ph6A:
undetectable		 2dcfA-4ph6A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 4ph6 3-DEHYDROQUINATE
DEHYDRATASE
(Enterococcus
faecalis) 		5 / 10 VAL A  19
VAL A  45
VAL A   6
ILE A  11
VAL A   9
 None
 1.30A 2qboA-4ph6A:
undetectable		 2qboA-4ph6A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 4ph6 3-DEHYDROQUINATE
DEHYDRATASE
(Enterococcus
faecalis) 		4 / 6 ASP A  41
LEU A 242
ASP A  43
LEU A  44
 None
 0.96A 3bj8C-4ph6A:
undetectable
3bj8D-4ph6A:
undetectable		 3bj8C-4ph6A:
21.40
3bj8D-4ph6A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 4ph6 3-DEHYDROQUINATE
DEHYDRATASE
(Enterococcus
faecalis) 		4 / 5 PHE A  92
ILE A 115
ASN A  54
PHE A  98
 None
 1.25A 3octA-4ph6A:
undetectable		 3octA-4ph6A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 4ph6 3-DEHYDROQUINATE
DEHYDRATASE
(Enterococcus
faecalis) 		4 / 6 LEU A 246
ALA A 222
LEU A 223
THR A 224
 None
 0.99A 3rozA-4ph6A:
undetectable		 3rozA-4ph6A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_D_SFYD803_0
(SEPIAPTERIN
REDUCTASE)		 4ph6 3-DEHYDROQUINATE
DEHYDRATASE
(Enterococcus
faecalis) 		5 / 11 LEU A 140
LEU A 223
PRO A 199
MET A 161
ALA A 166
 None
 1.42A 4hwkD-4ph6A:
2.1		 4hwkD-4ph6A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4ph6 3-DEHYDROQUINATE
DEHYDRATASE
(Enterococcus
faecalis) 		4 / 5 ARG A  10
GLY A  14
GLU A  13
ARG A 243
 None
 1.13A 5cdqR-4ph6A:
undetectable
5cdqS-4ph6A:
undetectable
5cdqT-4ph6A:
undetectable		 5cdqR-4ph6A:
19.05
5cdqS-4ph6A:
19.78
5cdqT-4ph6A:
19.05