SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4phb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		6 / 12 ILE A 276
VAL A 252
VAL A 261
ALA A 245
ILE A 239
ILE A 208
 None
 1.35A 1epbB-4phbA:
undetectable		 1epbB-4phbA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 7 LYS A 189
THR A 164
THR A 130
VAL A 128
 None
 0.69A 1ictD-4phbA:
undetectable		 1ictD-4phbA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A 124
GLY A 184
GLY A 159
GLU A 120
ILE A 186
 None
 0.97A 2wa2B-4phbA:
undetectable		 2wa2B-4phbA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A  56
GLY A  69
VAL A  95
VAL A  63
ILE A  65
 None
 1.06A 3cyxA-4phbA:
undetectable		 3cyxA-4phbA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 TYR A 135
ILE A 173
GLY A 172
ALA A 212
VAL A 165
 None
 1.01A 3jb3A-4phbA:
undetectable		 3jb3A-4phbA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_3
(HIV-1 PROTEASE)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A  56
GLY A  69
ILE A 111
VAL A  63
ILE A  65
 None
 1.00A 3k4vD-4phbA:
undetectable		 3k4vD-4phbA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A  56
GLY A  69
ILE A 111
VAL A  63
ILE A  65
 None
 1.03A 3nduC-4phbA:
undetectable		 3nduC-4phbA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLU A 120
ALA A 122
GLY A  98
SER A  74
ASP A 126
 None
 0.99A 3ou6C-4phbA:
undetectable		 3ou6C-4phbA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLU A 120
ALA A 122
GLY A  98
SER A  74
ASP A 126
 None
 0.98A 3ou6D-4phbA:
undetectable		 3ou6D-4phbA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 10 VAL A 230
ALA A 257
VAL A 259
ILE A 254
ILE A 217
 None
 1.41A 3retA-4phbA:
undetectable
3retB-4phbA:
undetectable		 3retA-4phbA:
15.60
3retB-4phbA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 9 ASP A 215
ILE A 217
GLY A 174
ILE A 149
ILE A 208
 GD  A 402 (-2.4A)
None
None
None
None
 0.96A 3s43A-4phbA:
undetectable		 3s43A-4phbA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 9 ASP A 209
ILE A 208
GLY A 194
ILE A 157
ILE A 186
 None
 0.78A 3s45A-4phbA:
undetectable		 3s45A-4phbA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 10 VAL A 165
ILE A 149
GLY A 174
ALA A 190
VAL A 188
 None
 0.88A 3t3cB-4phbA:
undetectable		 3t3cB-4phbA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A 172
GLY A 194
PHE A 191
ALA A 147
ASN A 170
 None
 1.30A 3t7sA-4phbA:
undetectable		 3t7sA-4phbA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A 172
GLY A 194
PHE A 191
ALA A 147
ASN A 170
 None
 1.30A 3t7sB-4phbA:
undetectable		 3t7sB-4phbA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A 172
GLY A 194
PHE A 191
ALA A 147
ASN A 170
 None
 1.31A 3t7sD-4phbA:
undetectable		 3t7sD-4phbA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 129
ILE A 149
CYH A 148
ILE A 111
LEU A  94
 None
 0.73A 3uj6A-4phbA:
undetectable		 3uj6A-4phbA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 7 VAL A  99
PHE A  43
VAL A  63
ILE A 119
 None
 0.97A 3zjqA-4phbA:
undetectable		 3zjqA-4phbA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 7 VAL A  99
PHE A  43
VAL A  63
ILE A 119
 None
 0.96A 3zjqB-4phbA:
undetectable		 3zjqB-4phbA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 11 ILE A 208
ILE A 210
GLY A 216
VAL A 165
GLY A 172
 None
 1.10A 4ac9B-4phbA:
undetectable
4ac9C-4phbA:
undetectable		 4ac9B-4phbA:
22.92
4ac9C-4phbA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLY A 194
ASP A 215
GLY A 216
VAL A 201
 None
GD  A 402 (-2.4A)
None
None
 0.81A 4c5nC-4phbA:
undetectable		 4c5nC-4phbA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A 124
GLY A 184
GLY A 159
GLU A 120
ILE A 186
 None
 0.83A 4ctjA-4phbA:
undetectable		 4ctjA-4phbA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A 124
GLY A 184
GLY A 159
GLU A 120
ILE A 186
 None
 0.91A 4ctjC-4phbA:
undetectable		 4ctjC-4phbA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_C_SAMC1263_0
(POLYPROTEIN)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A 124
GLY A 184
GLY A 159
GLU A 120
ILE A 186
 None
 0.88A 4ctkC-4phbA:
undetectable		 4ctkC-4phbA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 4 ASN A  38
VAL A  53
THR A  72
ILE A  41
 None
 1.43A 4retA-4phbA:
undetectable		 4retA-4phbA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 4 ASN A  38
VAL A  53
THR A  72
ILE A  41
 None
 1.43A 4retC-4phbA:
undetectable		 4retC-4phbA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A 173
GLY A 172
ALA A 212
VAL A 165
ILE A 186
 None
 0.99A 4rvdA-4phbA:
undetectable		 4rvdA-4phbA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A 173
GLY A 172
ALA A 212
VAL A 165
ILE A 186
 None
 1.00A 4rvgA-4phbA:
undetectable		 4rvgA-4phbA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ASP A 244
ASP A 215
ASP A 247
GLU A 220
 GD  A 402 (-3.7A)
GD  A 402 (-2.4A)
GD  A 402 (-3.7A)
None
 0.94A 5cfsA-4phbA:
undetectable		 5cfsA-4phbA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A 124
GLY A 184
GLY A 159
GLU A 120
ILE A 186
 None
 0.85A 5ehiA-4phbA:
undetectable		 5ehiA-4phbA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A 124
GLY A 184
GLY A 159
GLU A 120
ILE A 186
 None
 0.90A 5eiwA-4phbA:
undetectable		 5eiwA-4phbA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A 124
GLY A 184
GLY A 159
GLU A 120
ILE A 186
 None
 0.86A 5ekxB-4phbA:
undetectable		 5ekxB-4phbA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A 184
GLY A 216
ILE A 217
GLY A 235
GLY A 205
 None
 0.93A 5koxA-4phbA:
undetectable		 5koxA-4phbA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_D_SAMD301_0
(NS5)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A 124
GLY A 184
GLY A 159
GLU A 120
ILE A 186
 None
 0.97A 5njvD-4phbA:
undetectable		 5njvD-4phbA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A 210
ALA A 212
ILE A 246
ALA A 214
ILE A 203
 None
 1.15A 6a5zD-4phbA:
undetectable		 6a5zD-4phbA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4phb UNCHARACTERIZED
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 6 TYR A 110
ILE A 111
ARG A 152
ASP A 142
 None
None
None
GD  A 403 (-2.5A)
 1.16A 6hu9m-4phbA:
undetectable
6hu9q-4phbA:
undetectable		 6hu9m-4phbA:
19.92
6hu9q-4phbA:
15.76