SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4phc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 8 ASP A 177
ASP A 175
TYR A 336
THR A 132
 HIS  A1001 (-3.2A)
HIS  A1001 (-3.9A)
None
HIS  A1001 (-3.6A)
 1.10A 1ceaA-4phcA:
undetectable
1ceaB-4phcA:
undetectable		 1ceaA-4phcA:
10.14
1ceaB-4phcA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_A_HISA450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		7 / 10 THR A 132
ARG A 157
GLN A 173
ARG A 326
TYR A 330
TYR A 331
GLY A 360
 HIS  A1001 (-3.6A)
HIS  A1001 (-3.6A)
HIS  A1001 (-3.0A)
HIS  A1001 (-3.6A)
None
HIS  A1001 (-4.7A)
HIS  A1001 (-3.6A)
 0.56A 1httA-4phcA:
33.5		 1httA-4phcA:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		10 / 12 THR A 132
ARG A 157
GLN A 173
ARG A 326
LEU A 328
TYR A 330
TYR A 331
GLY A 360
TYR A 363
GLY A 381
 HIS  A1001 (-3.6A)
HIS  A1001 (-3.6A)
HIS  A1001 (-3.0A)
HIS  A1001 (-3.6A)
HIS  A1001 (-4.9A)
None
HIS  A1001 (-4.7A)
HIS  A1001 (-3.6A)
HIS  A1001 (-4.6A)
HIS  A1001 (-3.7A)
 0.53A 1httB-4phcA:
33.3		 1httB-4phcA:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		6 / 12 THR A 132
LEU A 328
TYR A 330
TYR A 331
GLY A 361
GLY A 381
 HIS  A1001 (-3.6A)
HIS  A1001 (-4.9A)
None
HIS  A1001 (-4.7A)
None
HIS  A1001 (-3.7A)
 1.24A 1httB-4phcA:
33.3		 1httB-4phcA:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		9 / 12 THR A 132
GLN A 173
ARG A 326
LEU A 328
TYR A 330
TYR A 331
GLY A 360
TYR A 363
GLY A 381
 HIS  A1001 (-3.6A)
HIS  A1001 (-3.0A)
HIS  A1001 (-3.6A)
HIS  A1001 (-4.9A)
None
HIS  A1001 (-4.7A)
HIS  A1001 (-3.6A)
HIS  A1001 (-4.6A)
HIS  A1001 (-3.7A)
 0.46A 1httC-4phcA:
33.6		 1httC-4phcA:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		6 / 12 THR A 132
LEU A 328
TYR A 330
TYR A 331
GLY A 361
GLY A 381
 HIS  A1001 (-3.6A)
HIS  A1001 (-4.9A)
None
HIS  A1001 (-4.7A)
None
HIS  A1001 (-3.7A)
 1.20A 1httC-4phcA:
33.6		 1httC-4phcA:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		9 / 12 THR A 132
ARG A 157
GLN A 173
ARG A 326
LEU A 328
TYR A 330
TYR A 331
GLY A 360
GLY A 381
 HIS  A1001 (-3.6A)
HIS  A1001 (-3.6A)
HIS  A1001 (-3.0A)
HIS  A1001 (-3.6A)
HIS  A1001 (-4.9A)
None
HIS  A1001 (-4.7A)
HIS  A1001 (-3.6A)
HIS  A1001 (-3.7A)
 0.58A 1httD-4phcA:
33.4		 1httD-4phcA:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		6 / 12 THR A 132
LEU A 328
TYR A 330
TYR A 331
GLY A 361
GLY A 381
 HIS  A1001 (-3.6A)
HIS  A1001 (-4.9A)
None
HIS  A1001 (-4.7A)
None
HIS  A1001 (-3.7A)
 1.15A 1httD-4phcA:
33.4		 1httD-4phcA:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 8 VAL A 226
LEU A 259
SER A 237
VAL A 238
 None
 0.91A 1jtvA-4phcA:
undetectable		 1jtvA-4phcA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 PHE A 231
ARG A 266
TYR A 270
PHE A 320
ILE A 223
 None
 1.29A 1mx8A-4phcA:
undetectable		 1mx8A-4phcA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 LEU A 382
SER A 383
GLN A 173
GLY A 361
GLY A 381
 None
HIS  A1001 (-4.5A)
HIS  A1001 (-3.0A)
None
HIS  A1001 (-3.7A)
 0.90A 1uakA-4phcA:
undetectable		 1uakA-4phcA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 ILE A 466
ILE A 465
ALA A 414
LEU A 427
ILE A 498
 None
 1.18A 1xzxX-4phcA:
undetectable		 1xzxX-4phcA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 8 LEU A 241
ILE A 234
PHE A 221
MET A 220
 None
 0.98A 2weyB-4phcA:
undetectable		 2weyB-4phcA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 PHE A 390
ILE A 389
ILE A 198
ILE A  81
VAL A 357
 None
 1.18A 3fpjB-4phcA:
undetectable		 3fpjB-4phcA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 8 LYS A 288
ASP A 286
LEU A 322
LEU A 283
 None
 1.02A 3lm8A-4phcA:
undetectable
3lm8C-4phcA:
undetectable		 3lm8A-4phcA:
16.90
3lm8C-4phcA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 8 ASP A 218
LEU A 217
ASN A 212
ILE A 335
 None
 1.05A 4k0bA-4phcA:
undetectable		 4k0bA-4phcA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 8 ASP A 218
LEU A 217
ASN A 212
ILE A 335
 None
 1.08A 4l7iA-4phcA:
undetectable		 4l7iA-4phcA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 5 GLN A 410
THR A 409
LEU A 427
LEU A 431
 None
 1.07A 4lvcB-4phcA:
undetectable		 4lvcB-4phcA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 THR A 132
GLY A 360
TYR A 363
GLY A 381
 HIS  A1001 (-3.6A)
HIS  A1001 (-3.6A)
HIS  A1001 (-4.6A)
HIS  A1001 (-3.7A)
 0.45A 4rdxA-4phcA:
31.2		 4rdxA-4phcA:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 THR A 132
TYR A 331
TYR A 363
GLY A 381
 HIS  A1001 (-3.6A)
HIS  A1001 (-4.7A)
HIS  A1001 (-4.6A)
HIS  A1001 (-3.7A)
 0.81A 4rdxA-4phcA:
31.2		 4rdxA-4phcA:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 ARG A 479
LYS A 477
GLU A 486
 None
 0.65A 5d0yA-4phcA:
0.4		 5d0yA-4phcA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 5 VAL A 380
VAL A 334
GLY A 333
ARG A 362
 None
 1.10A 5d4nA-4phcA:
undetectable
5d4nC-4phcA:
0.4		 5d4nA-4phcA:
12.95
5d4nC-4phcA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		9 / 12 THR A 132
ARG A 157
GLN A 173
LEU A 328
TYR A 330
TYR A 331
GLY A 360
TYR A 363
GLY A 381
 HIS  A1001 (-3.6A)
HIS  A1001 (-3.6A)
HIS  A1001 (-3.0A)
HIS  A1001 (-4.9A)
None
HIS  A1001 (-4.7A)
HIS  A1001 (-3.6A)
HIS  A1001 (-4.6A)
HIS  A1001 (-3.7A)
 0.47A 5e3iA-4phcA:
34.1		 5e3iA-4phcA:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		6 / 12 THR A 132
LEU A 328
TYR A 330
TYR A 331
GLY A 361
GLY A 381
 HIS  A1001 (-3.6A)
HIS  A1001 (-4.9A)
None
HIS  A1001 (-4.7A)
None
HIS  A1001 (-3.7A)
 1.23A 5e3iA-4phcA:
34.1		 5e3iA-4phcA:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 ARG A 157
TYR A 330
TYR A 363
GLY A 361
ALA A 359
 HIS  A1001 (-3.6A)
None
HIS  A1001 (-4.6A)
None
None
 1.35A 5e3iB-4phcA:
34.0		 5e3iB-4phcA:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		8 / 11 THR A 132
ARG A 157
GLN A 173
TYR A 330
TYR A 331
GLY A 360
TYR A 363
GLY A 381
 HIS  A1001 (-3.6A)
HIS  A1001 (-3.6A)
HIS  A1001 (-3.0A)
None
HIS  A1001 (-4.7A)
HIS  A1001 (-3.6A)
HIS  A1001 (-4.6A)
HIS  A1001 (-3.7A)
 0.42A 5e3iB-4phcA:
34.0		 5e3iB-4phcA:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 11 THR A 132
TYR A 330
TYR A 331
GLY A 361
GLY A 381
 HIS  A1001 (-3.6A)
None
HIS  A1001 (-4.7A)
None
HIS  A1001 (-3.7A)
 1.28A 5e3iB-4phcA:
34.0		 5e3iB-4phcA:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 ASP A 177
TYR A 336
GLY A 360
TYR A 330
 HIS  A1001 (-3.2A)
None
HIS  A1001 (-3.6A)
None
 1.00A 5hwaA-4phcA:
undetectable		 5hwaA-4phcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 6 VAL A 249
LEU A 322
SER A 323
ILE A 216
 None
 1.04A 5jw1A-4phcA:
undetectable		 5jw1A-4phcA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 4 GLN A 410
THR A 409
LEU A 427
LEU A 431
 None
 1.04A 5m5kB-4phcA:
undetectable		 5m5kB-4phcA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 PHE A  77
ILE A  80
ALA A 359
SER A 356
ILE A 384
 None
 1.26A 5mlmA-4phcA:
undetectable		 5mlmA-4phcA:
23.46