SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4phq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 4phq HEMOLYSIN E,
CHROMOSOMAL
(Escherichia
coli) 		5 / 12 THR A  19
ALA A  23
LEU A  24
TRP A  86
LEU A 127
 None
 1.19A 1errB-4phqA:
undetectable		 1errB-4phqA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 4phq HEMOLYSIN E,
CHROMOSOMAL
(Escherichia
coli) 		3 / 3 LEU A 120
LEU A  93
MET A 281
 None
 0.51A 1ya3B-4phqA:
undetectable		 1ya3B-4phqA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 4phq HEMOLYSIN E,
CHROMOSOMAL
(Escherichia
coli) 		5 / 12 GLY A  22
ALA A  23
ILE A 247
ILE A 253
VAL A 119
 None
 0.86A 2q5kB-4phqA:
undetectable		 2q5kB-4phqA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 4phq HEMOLYSIN E,
CHROMOSOMAL
(Escherichia
coli) 		3 / 3 ILE A 208
VAL A 170
ARG A 174
 None
 0.59A 3p73A-4phqA:
undetectable		 3p73A-4phqA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4phq HEMOLYSIN E,
CHROMOSOMAL
(Escherichia
coli) 		4 / 5 ASP A  64
THR A  67
LEU A  68
LYS A 147
 None
 0.88A 4a3pA-4phqA:
undetectable		 4a3pA-4phqA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 4phq HEMOLYSIN E,
CHROMOSOMAL
(Escherichia
coli) 		5 / 12 THR A  19
ALA A  23
LEU A  24
TRP A  86
LEU A 127
 None
 1.27A 4xi3D-4phqA:
undetectable		 4xi3D-4phqA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 4phq HEMOLYSIN E,
CHROMOSOMAL
(Escherichia
coli) 		5 / 12 TYR A 165
LEU A 215
GLU A  53
GLY A 188
ILE A 173
 None
 1.22A 5ifuA-4phqA:
undetectable		 5ifuA-4phqA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 4phq HEMOLYSIN E,
CHROMOSOMAL
(Escherichia
coli) 		3 / 3 LEU A  26
LEU A  31
TRP A  37
 None
 0.71A 5nwuA-4phqA:
undetectable		 5nwuA-4phqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4phq HEMOLYSIN E,
CHROMOSOMAL
(Escherichia
coli) 		4 / 8 ALA A  16
THR A 257
THR A 260
ALA A 109
 None
 0.96A 5x2tI-4phqA:
undetectable
5x2tJ-4phqA:
undetectable
5x2tK-4phqA:
undetectable
5x2tL-4phqA:
undetectable		 5x2tI-4phqA:
19.52
5x2tJ-4phqA:
19.33
5x2tK-4phqA:
19.52
5x2tL-4phqA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 4phq HEMOLYSIN E,
CHROMOSOMAL
(Escherichia
coli) 		5 / 12 GLY A  22
ALA A  23
ILE A 247
ILE A 253
VAL A 119
 None
 0.87A 6dj1B-4phqA:
undetectable		 6dj1B-4phqA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 4phq HEMOLYSIN E,
CHROMOSOMAL
(Escherichia
coli) 		5 / 12 GLY A  22
ALA A  23
ILE A 247
ILE A 253
VAL A 119
 None
 0.93A 6dj2B-4phqA:
undetectable		 6dj2B-4phqA:
11.30