SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4phs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 4phs PUTATIVE
GLYCOSYLTRANSFERASE
(GALT1)
(Streptococcus
parasanguinis) 		4 / 4 ILE A  42
MET A  37
VAL A  27
GLY A  32
 None
 1.23A 1e06B-4phsA:
undetectable		 1e06B-4phsA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 4phs PUTATIVE
GLYCOSYLTRANSFERASE
(GALT1)
(Streptococcus
parasanguinis) 		5 / 11 LEU A 200
ALA A 176
VAL A 146
LEU A 144
TYR A 180
 UDP  A 301 (-4.5A)
UDP  A 301 (-3.3A)
None
None
None
 1.16A 1rlbF-4phsA:
undetectable		 1rlbF-4phsA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 4phs PUTATIVE
GLYCOSYLTRANSFERASE
(GALT1)
(Streptococcus
parasanguinis) 		4 / 4 GLY A 110
SER A  63
VAL A  27
LEU A  71
 None
 1.36A 1yajB-4phsA:
undetectable		 1yajB-4phsA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4phs PUTATIVE
GLYCOSYLTRANSFERASE
(GALT1)
(Streptococcus
parasanguinis) 		5 / 9 LEU A 195
LEU A 143
ILE A 145
LEU A 221
ILE A 219
 None
 1.23A 2f78B-4phsA:
undetectable		 2f78B-4phsA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4phs PUTATIVE
GLYCOSYLTRANSFERASE
(GALT1)
(Streptococcus
parasanguinis) 		5 / 9 LEU A 195
LEU A 143
ILE A 145
LEU A 221
ILE A 219
 None
 1.16A 2f7aA-4phsA:
undetectable		 2f7aA-4phsA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4phs PUTATIVE
GLYCOSYLTRANSFERASE
(GALT1)
(Streptococcus
parasanguinis) 		5 / 9 LEU A 195
LEU A 143
ILE A 145
LEU A 221
ILE A 219
 None
 1.20A 2f7aB-4phsA:
undetectable		 2f7aB-4phsA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W4X_A_STZA1591_1
(O-GLCNACASE BT_4395)		 4phs PUTATIVE
GLYCOSYLTRANSFERASE
(GALT1)
(Streptococcus
parasanguinis) 		5 / 11 ASP A 181
TYR A 180
THR A 203
VAL A 206
ASN A  48
 None
 1.33A 2w4xA-4phsA:
undetectable		 2w4xA-4phsA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0Y_A_X0TA1625_1
(O-GLCNACASE NAGJ)		 4phs PUTATIVE
GLYCOSYLTRANSFERASE
(GALT1)
(Streptococcus
parasanguinis) 		5 / 12 ASP A 181
TYR A 180
THR A 203
VAL A 206
ASN A  48
 None
 1.38A 2x0yA-4phsA:
undetectable		 2x0yA-4phsA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_1
(NEURAMINIDASE A)		 4phs PUTATIVE
GLYCOSYLTRANSFERASE
(GALT1)
(Streptococcus
parasanguinis) 		5 / 12 ASP A 252
ILE A 255
TYR A 263
GLN A 264
ARG A 270
 None
 1.36A 2ya7A-4phsA:
undetectable		 2ya7A-4phsA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_1
(NEURAMINIDASE A)		 4phs PUTATIVE
GLYCOSYLTRANSFERASE
(GALT1)
(Streptococcus
parasanguinis) 		5 / 12 ASP A 252
ILE A 255
TYR A 263
GLN A 264
ARG A 270
 None
 1.36A 2ya7B-4phsA:
undetectable		 2ya7B-4phsA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_1
(NEURAMINIDASE A)		 4phs PUTATIVE
GLYCOSYLTRANSFERASE
(GALT1)
(Streptococcus
parasanguinis) 		5 / 12 ASP A 252
ILE A 255
TYR A 263
GLN A 264
ARG A 270
 None
 1.38A 2ya7D-4phsA:
undetectable		 2ya7D-4phsA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4phs PUTATIVE
GLYCOSYLTRANSFERASE
(GALT1)
(Streptococcus
parasanguinis) 		5 / 10 GLU A 248
ARG A 116
GLY A  30
LEU A  51
ILE A  42
 None
UDP  A 301 (-4.1A)
None
None
None
 1.31A 3adsA-4phsA:
undetectable		 3adsA-4phsA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4phs PUTATIVE
GLYCOSYLTRANSFERASE
(GALT1)
(Streptococcus
parasanguinis) 		4 / 6 GLY A 154
TYR A 228
GLU A 229
GLY A 156
 None
 1.08A 3e9rA-4phsA:
undetectable		 3e9rA-4phsA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4phs PUTATIVE
GLYCOSYLTRANSFERASE
(GALT1)
(Streptococcus
parasanguinis) 		4 / 6 GLY A 154
TYR A 228
GLU A 229
GLY A 156
 None
 1.08A 3e9rC-4phsA:
undetectable		 3e9rC-4phsA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4phs PUTATIVE
GLYCOSYLTRANSFERASE
(GALT1)
(Streptococcus
parasanguinis) 		5 / 11 GLN A  57
ASP A 210
ALA A 176
PHE A 177
ILE A 183
 None
None
UDP  A 301 (-3.3A)
None
None
 1.38A 3n23A-4phsA:
undetectable		 3n23A-4phsA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4phs PUTATIVE
GLYCOSYLTRANSFERASE
(GALT1)
(Streptococcus
parasanguinis) 		5 / 12 ALA A 191
ILE A  42
TYR A  44
GLY A  30
THR A 112
 None
None
UDP  A 301 (-3.5A)
None
None
 1.01A 5jlcA-4phsA:
undetectable		 5jlcA-4phsA:
20.85