SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4phz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4phz PARTICULATE METHANE
MONOOXYGENASE
SUBUNIT C
(Methylocystis
sp.
ATCC
49242) 		4 / 5 PRO K  97
THR K 255
VAL K 251
GLY K 250
 None
 1.01A 3elzA-4phzK:
undetectable		 3elzA-4phzK:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5R_A_KANA2002_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 4phz PARTICULATE METHANE
MONOOXYGENASE
SUBUNIT C
(Methylocystis
sp.
ATCC
49242) 		5 / 11 TYR K 157
ILE K  65
PHE K  34
GLU K  73
ILE K 156
 None
None
None
None
PGT  K 302 ( 4.9A)
 1.31A 3q5rA-4phzK:
undetectable		 3q5rA-4phzK:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 4phz PARTICULATE METHANE
MONOOXYGENASE
SUBUNIT C
(Methylocystis
sp.
ATCC
49242) 		5 / 10 TYR K 119
ILE K 118
ASN K  32
TYR K  35
ALA K 122
 None
 1.46A 3u6tA-4phzK:
undetectable		 3u6tA-4phzK:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 4phz PARTICULATE METHANE
MONOOXYGENASE
SUBUNIT C
(Methylocystis
sp.
ATCC
49242) 		5 / 9 ALA K 117
TYR K 119
PHE K 125
SER K 123
GLY K 121
 None
 1.21A 4mmeB-4phzK:
0.8		 4mmeB-4phzK:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4phz PARTICULATE METHANE
MONOOXYGENASE
SUBUNIT C
(Methylocystis
sp.
ATCC
49242) 		5 / 12 VAL K 234
LEU K  80
GLY K 163
ALA K 164
LEU K 111
 None
PGT  K 302 (-4.6A)
PGT  K 302 (-3.7A)
None
None
 1.13A 5iktA-4phzK:
0.8		 5iktA-4phzK:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4phz PARTICULATE METHANE
MONOOXYGENASE
SUBUNIT C
(Methylocystis
sp.
ATCC
49242) 		5 / 12 VAL K 234
LEU K  80
GLY K 163
ALA K 164
LEU K 111
 None
PGT  K 302 (-4.6A)
PGT  K 302 (-3.7A)
None
None
 1.14A 5iktB-4phzK:
undetectable		 5iktB-4phzK:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 4phz PARTICULATE METHANE
MONOOXYGENASE
SUBUNIT C
(Methylocystis
sp.
ATCC
49242) 		3 / 3 HIS K 146
ASP K 129
HIS K 133
 CU  K 301 (-3.3A)
CU  K 301 (-2.4A)
CU  K 301 (-3.5A)
 0.60A 5oexA-4phzK:
undetectable		 5oexA-4phzK:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 4phz PARTICULATE METHANE
MONOOXYGENASE
SUBUNIT C
(Methylocystis
sp.
ATCC
49242) 		3 / 3 HIS K 146
ASP K 129
HIS K 133
 CU  K 301 (-3.3A)
CU  K 301 (-2.4A)
CU  K 301 (-3.5A)
 0.64A 5oexB-4phzK:
undetectable		 5oexB-4phzK:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 4phz PARTICULATE METHANE
MONOOXYGENASE
SUBUNIT C
(Methylocystis
sp.
ATCC
49242) 		3 / 3 HIS K 146
ASP K 129
HIS K 133
 CU  K 301 (-3.3A)
CU  K 301 (-2.4A)
CU  K 301 (-3.5A)
 0.62A 5oexC-4phzK:
undetectable		 5oexC-4phzK:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 4phz PARTICULATE METHANE
MONOOXYGENASE
SUBUNIT C
(Methylocystis
sp.
ATCC
49242) 		3 / 3 HIS K 146
ASP K 129
HIS K 133
 CU  K 301 (-3.3A)
CU  K 301 (-2.4A)
CU  K 301 (-3.5A)
 0.62A 5oexD-4phzK:
undetectable		 5oexD-4phzK:
19.19