SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pia'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 4pia AUTOLYSIN E
(Staphylococcus
aureus) 		4 / 7 PHE A 117
ALA A 135
PHE A 161
PHE A 160
 None
 1.00A 1lqtA-4piaA:
undetectable		 1lqtA-4piaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4pia AUTOLYSIN E
(Staphylococcus
aureus) 		4 / 5 ILE A  89
ILE A 190
ILE A 129
MET A 238
 None
 0.90A 1zgyA-4piaA:
undetectable		 1zgyA-4piaA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4pia AUTOLYSIN E
(Staphylococcus
aureus) 		5 / 12 ILE A 234
PHE A 117
LEU A 104
ALA A 147
PHE A 160
 None
 1.17A 3apwB-4piaA:
undetectable		 3apwB-4piaA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4pia AUTOLYSIN E
(Staphylococcus
aureus) 		5 / 10 ILE A 190
VAL A 116
LYS A 115
GLY A 114
LEU A 136
 None
None
None
CL  A 309 (-4.1A)
None
 1.31A 3em0A-4piaA:
undetectable		 3em0A-4piaA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4pia AUTOLYSIN E
(Staphylococcus
aureus) 		5 / 12 PHE A 161
PHE A 117
GLY A 193
ALA A 189
ILE A 109
 None
 1.22A 3ld6B-4piaA:
undetectable		 3ld6B-4piaA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 4pia AUTOLYSIN E
(Staphylococcus
aureus) 		4 / 7 TYR A 130
VAL A 126
PHE A 161
ILE A 190
 None
 0.90A 3zjqA-4piaA:
undetectable		 3zjqA-4piaA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 4pia AUTOLYSIN E
(Staphylococcus
aureus) 		4 / 7 TYR A 130
VAL A 126
PHE A 161
ILE A 190
 None
 0.94A 3zjqB-4piaA:
undetectable		 3zjqB-4piaA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 4pia AUTOLYSIN E
(Staphylococcus
aureus) 		5 / 10 ALA A 135
LEU A 131
ILE A 163
TYR A 224
THR A 139
 None
 1.23A 4g8zX-4piaA:
undetectable		 4g8zX-4piaA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4pia AUTOLYSIN E
(Staphylococcus
aureus) 		3 / 3 HIS A 134
GLU A 138
TRP A 230
 None
 1.23A 5odiD-4piaA:
undetectable		 5odiD-4piaA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_ACTA504_0
(CARNOSINE
N-METHYLTRANSFERASE)		 4pia AUTOLYSIN E
(Staphylococcus
aureus) 		4 / 4 VAL A  37
ASN A  38
LYS A 258
TYR A 257
 None
 1.45A 5yf0A-4piaA:
0.0		 5yf0A-4piaA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_B_ACTB502_0
(CARNOSINE
N-METHYLTRANSFERASE)		 4pia AUTOLYSIN E
(Staphylococcus
aureus) 		4 / 4 VAL A  37
ASN A  38
LYS A 258
TYR A 257
 None
 1.46A 5yf0B-4piaA:
0.0		 5yf0B-4piaA:
21.66