SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pib'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 4pib INCLUSION BODY
PROTEIN
(Burkholderia
thailandensis) 		4 / 5 LYS A 157
ALA A 156
ASP A 109
GLY A 107
 None
None
None
CL  A 202 (-4.4A)
 1.15A 1e7cA-4pibA:
undetectable		 1e7cA-4pibA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 4pib INCLUSION BODY
PROTEIN
(Burkholderia
thailandensis) 		3 / 3 TRP A 183
TYR A 160
LEU A 105
 None
 1.00A 1kxhA-4pibA:
undetectable		 1kxhA-4pibA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 4pib INCLUSION BODY
PROTEIN
(Burkholderia
thailandensis) 		5 / 12 PHE A 159
LEU A 112
ALA A 148
THR A  23
VAL A 187
 None
 1.14A 2g78A-4pibA:
undetectable		 2g78A-4pibA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_D_BEZD194_0
(PUTATIVE KINASE)		 4pib INCLUSION BODY
PROTEIN
(Burkholderia
thailandensis) 		4 / 5 PRO A  63
ILE A  19
ARG A  64
ASP A  83
 None
 1.40A 2rhmD-4pibA:
undetectable		 2rhmD-4pibA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4pib INCLUSION BODY
PROTEIN
(Burkholderia
thailandensis) 		5 / 11 ALA A  79
ASP A  62
SER A  59
PHE A  88
VAL A 187
 None
None
None
GOL  A 206 (-4.6A)
None
 1.37A 4eilC-4pibA:
undetectable		 4eilC-4pibA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4pib INCLUSION BODY
PROTEIN
(Burkholderia
thailandensis) 		5 / 11 ALA A  79
ASP A  62
SER A  59
PHE A  88
VAL A 187
 None
None
None
GOL  A 206 (-4.6A)
None
 1.46A 4eilE-4pibA:
undetectable		 4eilE-4pibA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 4pib INCLUSION BODY
PROTEIN
(Burkholderia
thailandensis) 		4 / 8 LEU A 112
PHE A  87
LEU A  77
ILE A  75
 None
 1.01A 5mzjA-4pibA:
undetectable		 5mzjA-4pibA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 4pib INCLUSION BODY
PROTEIN
(Burkholderia
thailandensis) 		3 / 3 LYS A 182
TRP A 183
SER A  50
 None
 1.38A 5nwwA-4pibA:
undetectable		 5nwwA-4pibA:
13.61