SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pic'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZBZ_A_VDXA501_1 (CYTOCHROME P450-SU1)	4pic	ARGININE PHOSPHATASE YWLE (Geobacillus stearothermophil us)	5 / 11	THR A 82 SER A 65 LEU A 5 VAL A 78 ILE A 72	None	1.23A	2zbzA-4picA: undetectable	2zbzA-4picA: 18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3F78_B_ICFB2_1 (INTEGRIN ALPHA-L)	4pic	ARGININE PHOSPHATASE YWLE (Geobacillus stearothermophil us)	5 / 9	ILE A 58 LYS A 56 LEU A 21 GLU A 133 LEU A 132	None	1.43A	3f78B-4picA: 4.2	3f78B-4picA: 22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TBG_D_RTZD2_1 (CYTOCHROME P450 2D6)	4pic	ARGININE PHOSPHATASE YWLE (Geobacillus stearothermophil us)	5 / 9	LEU A 143 VAL A 30 GLU A 146 THR A 76 ILE A 4	None	1.03A	3tbgD-4picA: undetectable	3tbgD-4picA: 17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W9T_B_W9TB504_1 (HEMOLYTIC LECTIN CEL-III)	4pic	ARGININE PHOSPHATASE YWLE (Geobacillus stearothermophil us)	4 / 5	GLU A 31 GLY A 29 TYR A 2 GLN A 147	None	1.34A	3w9tB-4picA: undetectable	3w9tB-4picA: 15.35

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2ZBZ_A_VDXA501_1","CYTOCHROME P450-SU1","4pic","ARGININE PHOSPHATASE YWLE","Geobacillus stearothermophilus",5,"THR A  82;SER A  65;LEU A   5;VAL A  78;ILE A  72","None","1.23A","2zbzA-4picA:undetectable","2zbzA-4picA:18.69"],["3F78_B_ICFB2_1","INTEGRIN ALPHA-L","4pic","ARGININE PHOSPHATASE YWLE","Geobacillus stearothermophilus",5,"ILE A  58;LYS A  56;LEU A  21;GLU A 133;LEU A 132","None","1.43A","3f78B-4picA:4.2","3f78B-4picA:22.56"],["3TBG_D_RTZD2_1","CYTOCHROME P450 2D6","4pic","ARGININE PHOSPHATASE YWLE","Geobacillus stearothermophilus",5,"LEU A 143;VAL A  30;GLU A 146;THR A  76;ILE A   4","None","1.03A","3tbgD-4picA:undetectable","3tbgD-4picA:17.63"],["3W9T_B_W9TB504_1","HEMOLYTIC LECTIN CEL-III","4pic","ARGININE PHOSPHATASE YWLE","Geobacillus stearothermophilus",4,"GLU A  31;GLY A  29;TYR A   2;GLN A 147","None","1.34A","3w9tB-4picA:undetectable","3w9tB-4picA:15.35"]]