SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pii'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4pii N-GLYCOSYLASE/DNA
LYASE
(Pyrococcus
furiosus) 		4 / 7 SER A  72
PHE A  67
PHE A  42
LEU A 119
 None
 0.93A 1qcaA-4piiA:
undetectable		 1qcaA-4piiA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 4pii N-GLYCOSYLASE/DNA
LYASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 233
LEU A 217
ILE A 179
LEU A   4
LEU A 186
 None
 1.11A 1s19A-4piiA:
undetectable		 1s19A-4piiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 4pii N-GLYCOSYLASE/DNA
LYASE
(Pyrococcus
furiosus) 		3 / 3 PHE A 164
SER A 211
LEU A 207
 None
 0.76A 2w1bA-4piiA:
1.8		 2w1bA-4piiA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4pii N-GLYCOSYLASE/DNA
LYASE
(Pyrococcus
furiosus) 		4 / 6 GLN A  31
PHE A  34
PHE A  42
PHE A 153
 CL  A 306 (-4.4A)
None
None
None
 1.11A 3ablP-4piiA:
undetectable
3ablW-4piiA:
undetectable		 3ablP-4piiA:
18.15
3ablW-4piiA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4pii N-GLYCOSYLASE/DNA
LYASE
(Pyrococcus
furiosus) 		4 / 7 ILE A 213
ILE A  13
LEU A 240
LEU A 229
 None
CL  A 305 (-4.5A)
None
None
 0.83A 3adxA-4piiA:
undetectable		 3adxA-4piiA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 4pii N-GLYCOSYLASE/DNA
LYASE
(Pyrococcus
furiosus) 		5 / 11 SER A 157
GLY A 154
ALA A 156
ILE A  43
ILE A  47
 None
 0.99A 4dt8A-4piiA:
undetectable		 4dt8A-4piiA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4pii N-GLYCOSYLASE/DNA
LYASE
(Pyrococcus
furiosus) 		3 / 3 TYR A 167
PHE A  27
ARG A 158
 None
 1.24A 4g19D-4piiA:
undetectable		 4g19D-4piiA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 4pii N-GLYCOSYLASE/DNA
LYASE
(Pyrococcus
furiosus) 		5 / 10 ALA A  48
LEU A  51
VAL A  52
LEU A 133
GLU A 108
 None
 0.97A 5v02B-4piiA:
undetectable
5v02R-4piiA:
undetectable		 5v02B-4piiA:
20.40
5v02R-4piiA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4pii N-GLYCOSYLASE/DNA
LYASE
(Pyrococcus
furiosus) 		4 / 6 GLN A  31
PHE A  34
PHE A  42
PHE A 153
 CL  A 306 (-4.4A)
None
None
None
 0.99A 5z84P-4piiA:
undetectable
5z84W-4piiA:
undetectable		 5z84P-4piiA:
18.15
5z84W-4piiA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4pii N-GLYCOSYLASE/DNA
LYASE
(Pyrococcus
furiosus) 		4 / 6 GLN A  31
PHE A  34
PHE A  42
PHE A 153
 CL  A 306 (-4.4A)
None
None
None
 0.94A 5z85P-4piiA:
undetectable
5z85W-4piiA:
undetectable		 5z85P-4piiA:
18.15
5z85W-4piiA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4pii N-GLYCOSYLASE/DNA
LYASE
(Pyrococcus
furiosus) 		4 / 6 GLN A  31
PHE A  34
PHE A  42
PHE A 153
 CL  A 306 (-4.4A)
None
None
None
 0.99A 5z86P-4piiA:
undetectable
5z86W-4piiA:
undetectable		 5z86P-4piiA:
18.15
5z86W-4piiA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4pii N-GLYCOSYLASE/DNA
LYASE
(Pyrococcus
furiosus) 		4 / 6 GLN A  31
PHE A  34
PHE A  42
PHE A 153
 CL  A 306 (-4.4A)
None
None
None
 1.04A 5zcoP-4piiA:
undetectable
5zcoW-4piiA:
undetectable		 5zcoP-4piiA:
18.15
5zcoW-4piiA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4pii N-GLYCOSYLASE/DNA
LYASE
(Pyrococcus
furiosus) 		4 / 6 GLN A  31
PHE A  34
PHE A  42
PHE A 153
 CL  A 306 (-4.4A)
None
None
None
 1.04A 5zcpP-4piiA:
undetectable
5zcpW-4piiA:
undetectable		 5zcpP-4piiA:
18.15
5zcpW-4piiA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 4pii N-GLYCOSYLASE/DNA
LYASE
(Pyrococcus
furiosus) 		4 / 6 VAL A 204
LEU A 222
ARG A  25
PRO A 215
 None
 1.27A 6brdB-4piiA:
undetectable		 6brdB-4piiA:
13.47