SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pir'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 4pir 5-HYDROXYTRYPTAMINE
RECEPTOR 3A
(Mus
musculus) 		3 / 4 VAL A  39
TRP A 168
TRP A  68
 None
 1.26A 1gmkA-4pirA:
undetectable
1gmkB-4pirA:
undetectable		 1gmkA-4pirA:
4.05
1gmkB-4pirA:
4.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 4pir VHH15
(Lama
glama) 		4 / 7 ASP F  66
VAL F  68
GLY F  50
ILE F  51
 None
 0.82A 1t7iB-4pirF:
undetectable		 1t7iB-4pirF:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 4pir 5-HYDROXYTRYPTAMINE
RECEPTOR 3A
(Mus
musculus) 		4 / 4 ASP A 238
LEU A 259
LEU A 298
LEU A 258
 None
 1.16A 1u18A-4pirA:
undetectable		 1u18A-4pirA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 4pir 5-HYDROXYTRYPTAMINE
RECEPTOR 3A
(Mus
musculus) 		3 / 3 CYH A 243
PHE A 242
PHE A 438
 None
 0.77A 3cr5X-4pirA:
undetectable		 3cr5X-4pirA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4pir VHH15
(Lama
glama) 		4 / 4 LEU F  47
MET F  87
ILE F  31
ASP F  60
 None
 1.37A 3hecA-4pirF:
undetectable		 3hecA-4pirF:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 4pir 5-HYDROXYTRYPTAMINE
RECEPTOR 3A
(Mus
musculus) 		3 / 3 ASP A 238
SER A 297
ARG A 251
 None
 1.00A 3loqA-4pirA:
undetectable		 3loqA-4pirA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4pir 5-HYDROXYTRYPTAMINE
RECEPTOR 3A
(Mus
musculus) 		5 / 10 SER A 155
ILE A  41
VAL A  39
ALA A 208
ILE A 165
 None
 1.06A 4lbgA-4pirA:
undetectable		 4lbgA-4pirA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 4pir 5-HYDROXYTRYPTAMINE
RECEPTOR 3A
(Mus
musculus) 		3 / 3 ARG A 217
ASP A 145
ARG A 218
 None
 0.43A 4wq4B-4pirA:
undetectable		 4wq4B-4pirA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 4pir 5-HYDROXYTRYPTAMINE
RECEPTOR 3A
(Mus
musculus) 		4 / 6 ILE A 302
ARG A 251
ILE A 304
GLU A 300
 None
 1.18A 4zzcB-4pirA:
21.7
4zzcC-4pirA:
21.8		 4zzcB-4pirA:
22.89
4zzcC-4pirA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 4pir 5-HYDROXYTRYPTAMINE
RECEPTOR 3A
(Mus
musculus) 		4 / 6 PHE A 142
ASN A 141
LEU A 282
GLY A 284
 None
 1.04A 5o4yA-4pirA:
undetectable		 5o4yA-4pirA:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 4pir 5-HYDROXYTRYPTAMINE
RECEPTOR 3A
(Mus
musculus) 		4 / 5 THR A  90
LEU A 129
VAL A 106
LEU A  99
 None
 1.01A 6bqgA-4pirA:
1.4		 6bqgA-4pirA:
11.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4pir 5-HYDROXYTRYPTAMINE
RECEPTOR 3A
(Mus
musculus) 		4 / 8 ASP A  42
ILE A  44
TRP A  63
ARG A 169
 None
 0.84A 6hisA-4pirA:
39.2
6hisB-4pirA:
39.2		 6hisA-4pirA:
100.00
6hisB-4pirA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4pir 5-HYDROXYTRYPTAMINE
RECEPTOR 3A
(Mus
musculus) 		4 / 8 ASP A  42
ILE A  44
TRP A  63
ARG A 169
 None
 0.84A 6hisB-4pirA:
39.2
6hisC-4pirA:
39.2		 6hisB-4pirA:
100.00
6hisC-4pirA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4pir 5-HYDROXYTRYPTAMINE
RECEPTOR 3A
(Mus
musculus) 		4 / 8 ASP A  42
ILE A  44
TRP A  63
ARG A 169
 None
 0.84A 6hisC-4pirA:
39.2
6hisD-4pirA:
39.2		 6hisC-4pirA:
100.00
6hisD-4pirA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4pir 5-HYDROXYTRYPTAMINE
RECEPTOR 3A
(Mus
musculus) 		4 / 8 ASP A  42
ILE A  44
TRP A  63
ARG A 169
 None
 0.85A 6hisD-4pirA:
39.2
6hisE-4pirA:
39.2		 6hisD-4pirA:
100.00
6hisE-4pirA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4pir 5-HYDROXYTRYPTAMINE
RECEPTOR 3A
(Mus
musculus) 		4 / 8 ASP A  42
ILE A  44
TRP A  63
ARG A 169
 None
 0.86A 6hisA-4pirA:
39.2
6hisE-4pirA:
39.2		 6hisA-4pirA:
100.00
6hisE-4pirA:
100.00