SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4piv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 5 LEU A1134
LEU A1128
LEU A1400
GLY A1217
 None
 0.97A 1a4lC-4pivA:
undetectable		 1a4lC-4pivA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 10 GLY A2035
PHE A2036
SER A2032
LEU A1460
LEU A1980
 None
 1.16A 1a8uA-4pivA:
4.3		 1a8uA-4pivA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 10 GLY A2035
PHE A2036
SER A2032
LEU A1460
LEU A1980
 None
 1.13A 1a8uB-4pivA:
4.2		 1a8uB-4pivA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		3 / 3 ALA A1272
VAL A1245
TRP A1297
 None
 0.87A 1av2C-4pivA:
undetectable
1av2D-4pivA:
undetectable		 1av2C-4pivA:
3.18
1av2D-4pivA:
3.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 10 ARG A1468
VAL A1453
ASN A1234
ILE A1413
LEU A1469
 None
 1.12A 1fe2A-4pivA:
undetectable		 1fe2A-4pivA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 8 THR A1120
PRO A1121
GLY A1512
PHE A1517
THR A1230
 None
 1.33A 1h4oB-4pivA:
undetectable		 1h4oB-4pivA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_C_BEZC1162_0
(PEROXIREDOXIN 5)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 9 THR A1120
PRO A1121
GLY A1512
PHE A1517
THR A1230
 None
 1.34A 1h4oC-4pivA:
undetectable
1h4oD-4pivA:
undetectable		 1h4oC-4pivA:
13.43
1h4oD-4pivA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_E_BEZE1162_0
(PEROXIREDOXIN 5)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 9 THR A1120
PRO A1121
GLY A1512
PHE A1517
THR A1230
 None
 1.34A 1h4oE-4pivA:
undetectable
1h4oF-4pivA:
undetectable		 1h4oE-4pivA:
13.43
1h4oF-4pivA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_H_BEZH1162_0
(PEROXIREDOXIN 5)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 9 THR A1120
PRO A1121
GLY A1512
PHE A1517
THR A1230
 None
 1.33A 1h4oH-4pivA:
undetectable		 1h4oH-4pivA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 5 SER A1942
THR A1915
GLU A1958
GLY A1954
 None
NDP  A2202 (-4.5A)
None
None
 1.27A 1icvC-4pivA:
undetectable
1icvD-4pivA:
undetectable		 1icvC-4pivA:
16.03
1icvD-4pivA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 5 GLU A1958
GLY A1954
SER A1942
THR A1915
 None
None
None
NDP  A2202 (-4.5A)
 1.31A 1kqbA-4pivA:
undetectable
1kqbB-4pivA:
undetectable		 1kqbA-4pivA:
16.51
1kqbB-4pivA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 HIS A1122
ASN A1234
LEU A1402
ASN A1458
VAL A1454
 None
 1.34A 1mrlB-4pivA:
undetectable
1mrlC-4pivA:
undetectable		 1mrlB-4pivA:
14.22
1mrlC-4pivA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 LEU A1336
ALA A1310
LYS A1241
LEU A1312
VAL A1245
 None
 1.14A 1sa1A-4pivA:
6.2
1sa1B-4pivA:
5.9		 1sa1A-4pivA:
21.02
1sa1B-4pivA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 11 GLY A1217
SER A1394
SER A1398
THR A1361
ILE A1356
 None
 1.15A 2nnhA-4pivA:
undetectable		 2nnhA-4pivA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 LEU A1497
GLY A1499
LEU A1493
SER A1411
PRO A1412
 None
 1.06A 2vmyA-4pivA:
2.2		 2vmyA-4pivA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 7 GLU A1426
SER A1427
VAL A1425
TRP A1424
 None
 1.47A 3dqtA-4pivA:
undetectable
3dqtB-4pivA:
undetectable		 3dqtA-4pivA:
22.06
3dqtB-4pivA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 5 LEU A2056
LYS A1116
GLN A2059
LEU A2106
 None
SO4  A2203 ( 4.8A)
None
None
 1.07A 3h5gA-4pivA:
undetectable
3h5gB-4pivA:
undetectable		 3h5gA-4pivA:
3.79
3h5gB-4pivA:
3.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 8 LEU A1342
ARG A1405
VAL A1384
ALA A1334
 None
 0.94A 3uniB-4pivA:
undetectable		 3uniB-4pivA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 9 LEU A1228
LYS A1225
TYR A1270
GLY A1258
LEU A1252
 None
 1.44A 4b3oA-4pivA:
2.7		 4b3oA-4pivA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 11 SER A1942
VAL A1939
LEU A1914
THR A1915
ALA A1901
 None
None
None
NDP  A2202 (-4.5A)
None
 1.16A 4e0fA-4pivA:
undetectable		 4e0fA-4pivA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 6 PRO A1264
GLY A2061
ALA A2112
GLN A2031
 2W4  A2205 (-4.4A)
2W4  A2205 (-4.9A)
None
2W4  A2205 ( 4.1A)
 1.12A 4g0uA-4pivA:
undetectable		 4g0uA-4pivA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 7 SER A2021
GLN A2031
TYR A2034
LEU A2069
 2W4  A2205 (-2.7A)
2W4  A2205 ( 4.1A)
2W4  A2205 ( 4.4A)
NDP  A2202 ( 3.5A)
 0.83A 4hxyB-4pivA:
36.1		 4hxyB-4pivA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 5 LEU A1259
SER A1254
LEU A1219
ASN A1316
 None
 1.25A 4n09C-4pivA:
4.7		 4n09C-4pivA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 6 ARG A1953
GLY A1951
SER A1948
LEU A1949
 None
 1.29A 5bphA-4pivA:
undetectable		 5bphA-4pivA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 LEU A1386
LEU A1336
LEU A1342
ARG A1383
PRO A1299
 None
 1.18A 5hnwB-4pivA:
5.7		 5hnwB-4pivA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A1946
VAL A2018
PHE A2016
ILE A1956
ALA A1952
 None
 1.01A 5n0sA-4pivA:
2.2		 5n0sA-4pivA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A1946
VAL A2018
PHE A2016
ILE A1956
ALA A1952
 None
 1.02A 5n0sB-4pivA:
undetectable		 5n0sB-4pivA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A1946
VAL A2018
PHE A2016
ILE A1956
ALA A1952
 None
 1.02A 5n0tA-4pivA:
undetectable		 5n0tA-4pivA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A1946
VAL A2018
PHE A2016
ILE A1956
ALA A1952
 None
 0.97A 5n0wB-4pivA:
undetectable		 5n0wB-4pivA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 ILE A1946
VAL A2018
PHE A2016
ILE A1956
ALA A1952
 None
 0.95A 5n4iA-4pivA:
2.2		 5n4iA-4pivA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O45_B_CCSB13_0
(PHE-MEA-9KK-SAR-ASP-
VAL-MEA-TYR-SAR-TRP-
TYR-LEU-CCS-GLY-NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 9 GLU A1244
ASN A1316
VAL A1319
TYR A1253
GLY A1248
 None
 1.45A 5o45A-4pivA:
0.0
5o45B-4pivA:
undetectable		 5o45A-4pivA:
12.12
5o45B-4pivA:
1.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 6 GLU A1137
LEU A1134
LEU A1215
LEU A1353
 None
 1.19A 5yvnA-4pivA:
undetectable		 5yvnA-4pivA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 11 VAL A1245
LEU A1342
ALA A1303
VAL A1242
TYR A1270
 None
 1.08A 6dryA-4pivA:
undetectable		 6dryA-4pivA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 4piv FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A1895
GLY A1897
ALA A1901
ILE A2068
VAL A2070
 NDP  A2202 (-3.6A)
None
None
2W4  A2205 (-3.9A)
None
 1.06A 6iftA-4pivA:
9.1		 6iftA-4pivA:
18.22