SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pj1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 ILE A  99
LEU A 427
VAL A 124
ALA A 509
LEU A 505
 None
 1.17A 1e7bA-4pj1A:
undetectable		 1e7bA-4pj1A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 LEU A 334
LEU A 373
GLY A 376
ILE A 189
 None
 0.83A 1mt1G-4pj1A:
undetectable
1mt1J-4pj1A:
undetectable		 1mt1G-4pj1A:
7.01
1mt1J-4pj1A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 189
LEU A 334
LEU A 373
GLY A 376
 None
 0.82A 1mt1H-4pj1A:
undetectable
1mt1K-4pj1A:
undetectable		 1mt1H-4pj1A:
11.71
1mt1K-4pj1A:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 LEU A 370
THR A 296
LEU A 373
VAL A 321
 None
 0.73A 1sn5C-4pj1A:
undetectable		 1sn5C-4pj1A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 LEU A 187
LEU A 380
ILE A 161
GLU A 409
LEU A 401
 None
 1.25A 1wopA-4pj1A:
undetectable		 1wopA-4pj1A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B82_A_ADNA1001_1
(CLASS B ACID
PHOSPHATASE)		 4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 PHE A 104
LYS A 106
GLU A 102
GLY A  19
ASP A  21
 None
 1.44A 2b82A-4pj1A:
2.0		 2b82A-4pj1A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLY A 154
ALA A 152
THR A 404
ILE A 158
 None
 0.73A 2dtjA-4pj1A:
undetectable
2dtjB-4pj1A:
undetectable		 2dtjA-4pj1A:
16.46
2dtjB-4pj1A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 ILE A 227
ILE A 230
GLY A 256
GLU A 257
ALA A 258
 None
 1.18A 2dtjA-4pj1A:
undetectable
2dtjB-4pj1A:
undetectable		 2dtjA-4pj1A:
16.46
2dtjB-4pj1A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 MET A 193
ILE A 343
ARG A 346
PRO A 279
 None
 1.00A 2qd3B-4pj1A:
2.2		 2qd3B-4pj1A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 SER A 232
LEU A 308
GLY A 302
GLU A 311
 None
 1.02A 3aiaA-4pj1A:
undetectable
3aiaB-4pj1A:
undetectable		 3aiaA-4pj1A:
16.55
3aiaB-4pj1A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 262
THR A 261
ALA A 236
ALA A 240
LEU A 247
 None
 1.18A 3p5nA-4pj1A:
undetectable		 3p5nA-4pj1A:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 GLY A  53
VAL A  54
ASP A  52
THR A  50
 None
 1.22A 3vqrA-4pj1A:
undetectable		 3vqrA-4pj1A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 GLY A  53
VAL A  54
ASP A  52
THR A  50
 None
 1.22A 3vqrB-4pj1A:
undetectable		 3vqrB-4pj1A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 MET A 193
ILE A 343
ARG A 346
PRO A 279
 None
 1.04A 4f4dB-4pj1A:
undetectable		 4f4dB-4pj1A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 LEU A 370
THR A 296
LEU A 373
VAL A 321
 None
 0.75A 4ik7B-4pj1A:
undetectable		 4ik7B-4pj1A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 GLY A 416
GLY A 415
GLY A 463
PHE A 486
ILE A 470
 ADP  A 601 (-3.2A)
ADP  A 601 (-3.5A)
None
None
None
 1.12A 4qoiA-4pj1A:
undetectable
4qoiB-4pj1A:
undetectable		 4qoiA-4pj1A:
19.14
4qoiB-4pj1A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 ALA A 456
ALA A 459
GLY A 417
GLY A 416
ASP A 480
 None
None
ADP  A 601 ( 4.9A)
ADP  A 601 (-3.2A)
ADP  A 601 (-3.9A)
 1.13A 4qwuK-4pj1A:
undetectable
4qwuL-4pj1A:
undetectable		 4qwuK-4pj1A:
16.19
4qwuL-4pj1A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 ALA A 456
ALA A 459
GLY A 417
GLY A 416
ASP A 480
 None
None
ADP  A 601 ( 4.9A)
ADP  A 601 (-3.2A)
ADP  A 601 (-3.9A)
 1.14A 4qwuY-4pj1A:
undetectable
4qwuZ-4pj1A:
undetectable		 4qwuY-4pj1A:
16.19
4qwuZ-4pj1A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA A  92
GLY A  53
ALA A 403
GLY A  86
GLU A  84
 None
 1.28A 4r29C-4pj1A:
1.7		 4r29C-4pj1A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ASP A 480
ILE A 455
ALA A 452
GLY A 415
GLY A  35
 ADP  A 601 (-3.9A)
ADP  A 601 (-4.3A)
None
ADP  A 601 (-3.5A)
None
 0.99A 5i73A-4pj1A:
2.7		 5i73A-4pj1A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 VAL A 124
ILE A 128
ALA A 129
LYS A 132
GLY A 510
 None
 0.69A 5j2tC-4pj1A:
undetectable		 5j2tC-4pj1A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA407_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ASP A 507
THR A 503
ARG A 502
GLU A  84
 None
 1.44A 5k9dA-4pj1A:
undetectable		 5k9dA-4pj1A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 THR A  91
GLY A  88
GLY A 510
VAL A 124
ILE A 444
 ADP  A 601 (-4.0A)
ADP  A 601 (-3.5A)
None
None
None
 1.15A 5tuiB-4pj1A:
undetectable		 5tuiB-4pj1A:
25.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 ILE A 161
ASP A 185
VAL A 382
ASP A 164
ALA A 165
ALA A 400
 None
 1.08A 6bq4A-4pj1A:
undetectable		 6bq4A-4pj1A:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 ILE A 161
ASP A 185
VAL A 382
ASP A 164
ALA A 165
ALA A 400
 None
 1.07A 6bq4B-4pj1A:
undetectable		 6bq4B-4pj1A:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 4pj1 60 KDA HEAT SHOCK
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ALA A 400
THR A 404
ILE A 144
ALA A 145
 None
 0.93A 6ma7A-4pj1A:
1.6		 6ma7A-4pj1A:
8.62