SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pj3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_2
(HMG-COA REDUCTASE)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		5 / 11 CYH A 385
HIS A 411
SER A 336
LEU A 337
ALA A 340
 None
 1.33A 1hwkB-4pj3A:
undetectable		 1hwkB-4pj3A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_B_117B1_1
(HMG-COA REDUCTASE)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		5 / 11 CYH A 385
HIS A 411
SER A 336
LEU A 337
ALA A 340
 None
 1.33A 1hwkA-4pj3A:
undetectable		 1hwkA-4pj3A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_2
(HMG-COA REDUCTASE)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		5 / 11 CYH A 385
HIS A 411
SER A 336
LEU A 337
ALA A 340
 None
 1.32A 1hwkD-4pj3A:
undetectable		 1hwkD-4pj3A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_1
(HMG-COA REDUCTASE)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		5 / 11 CYH A 385
HIS A 411
SER A 336
LEU A 337
ALA A 340
 None
 1.32A 1hwkC-4pj3A:
undetectable		 1hwkC-4pj3A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		5 / 12 LEU A 150
PHE A 138
ALA A 132
ALA A 130
LEU A 222
 None
 1.38A 1kt5A-4pj3A:
undetectable		 1kt5A-4pj3A:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		5 / 12 GLY A 817
ALA A 700
SER A 699
TYR A 702
SER A 703
 None
 1.11A 1nt2A-4pj3A:
undetectable		 1nt2A-4pj3A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 6 LEU A 193
TRP A 197
LEU A 183
TRP A 175
 None
 1.21A 1ru9H-4pj3A:
undetectable
1ru9L-4pj3A:
undetectable		 1ru9H-4pj3A:
10.36
1ru9L-4pj3A:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 5 LEU A 193
TRP A 197
LEU A 183
TRP A 175
 None
 1.24A 1ruaH-4pj3A:
undetectable
1ruaL-4pj3A:
undetectable		 1ruaH-4pj3A:
10.36
1ruaL-4pj3A:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUL_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 5 LEU A 193
TRP A 197
LEU A 183
TRP A 175
 None
 1.22A 1rulH-4pj3A:
undetectable
1rulL-4pj3A:
undetectable		 1rulH-4pj3A:
10.36
1rulL-4pj3A:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 5 PHE A1123
LEU A1088
MET A1061
LEU A1068
 None
 1.31A 1skxA-4pj3A:
undetectable		 1skxA-4pj3A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		3 / 3 ILE A 709
ASP A 713
PHE A 714
 None
 0.57A 1uwjB-4pj3A:
undetectable		 1uwjB-4pj3A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 6 LEU A1119
MET A 820
THR A 819
LEU A 818
 None
 0.96A 1v54A-4pj3A:
undetectable
1v54J-4pj3A:
undetectable		 1v54A-4pj3A:
15.67
1v54J-4pj3A:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 7 LEU A1119
MET A 820
THR A 819
LEU A 818
 None
 0.91A 1v54N-4pj3A:
undetectable
1v54W-4pj3A:
undetectable		 1v54N-4pj3A:
15.67
1v54W-4pj3A:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		5 / 9 PHE A 253
PHE A 298
VAL A 289
PHE A 402
LEU A 302
 None
 1.37A 1wrkA-4pj3A:
undetectable
1wrkB-4pj3A:
undetectable		 1wrkA-4pj3A:
4.72
1wrkB-4pj3A:
4.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		3 / 3 LEU A 475
LEU A 450
MET A 304
 None
 0.77A 1ya3B-4pj3A:
undetectable		 1ya3B-4pj3A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 7 PHE A 583
GLU A 430
VAL A 592
VAL A 567
 None
 1.25A 1zzrA-4pj3A:
undetectable
1zzrB-4pj3A:
undetectable		 1zzrA-4pj3A:
14.14
1zzrB-4pj3A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 8 PHE A1320
LEU A1284
LEU A1273
LEU A1301
 None
 0.93A 2bfpD-4pj3A:
undetectable		 2bfpD-4pj3A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 6 LEU A1119
MET A 820
THR A 819
LEU A 818
 None
 0.96A 2dyrA-4pj3A:
1.1
2dyrJ-4pj3A:
undetectable		 2dyrA-4pj3A:
15.67
2dyrJ-4pj3A:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 7 LEU A1119
MET A 820
THR A 819
LEU A 818
 None
 0.93A 2dyrN-4pj3A:
undetectable
2dyrW-4pj3A:
undetectable		 2dyrN-4pj3A:
15.67
2dyrW-4pj3A:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 6 LEU A1119
MET A 820
THR A 819
LEU A 818
 None
 0.95A 2dysA-4pj3A:
1.2
2dysJ-4pj3A:
undetectable		 2dysA-4pj3A:
15.67
2dysJ-4pj3A:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 6 LEU A1119
MET A 820
THR A 819
LEU A 818
 None
 0.96A 2dysN-4pj3A:
undetectable
2dysW-4pj3A:
undetectable		 2dysN-4pj3A:
15.67
2dysW-4pj3A:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 6 LEU A1119
MET A 820
THR A 819
LEU A 818
 None
 0.95A 2eijA-4pj3A:
undetectable
2eijJ-4pj3A:
undetectable		 2eijA-4pj3A:
15.67
2eijJ-4pj3A:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 6 LEU A1119
MET A 820
THR A 819
LEU A 818
 None
 0.94A 2eilA-4pj3A:
2.2
2eilJ-4pj3A:
undetectable		 2eilA-4pj3A:
15.67
2eilJ-4pj3A:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_A_SCKA902_1
(ACETYLCHOLINESTERASE)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		5 / 10 GLU A1069
ASN A 469
LEU A1078
LEU A 850
TYR A1056
 None
 1.30A 2ha6A-4pj3A:
undetectable		 2ha6A-4pj3A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_B_SCKB952_1
(ACETYLCHOLINESTERASE)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		5 / 10 GLU A1069
ASN A 469
LEU A1078
LEU A 850
TYR A1056
 None
 1.34A 2ha6B-4pj3A:
undetectable		 2ha6B-4pj3A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO6_B_ETVB302_1
(DEOXYCYTIDINE KINASE)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		5 / 11 ILE A 691
GLU A1069
MET A1061
ARG A1122
PHE A1123
 None
 1.49A 2no6B-4pj3A:
undetectable		 2no6B-4pj3A:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		3 / 3 GLY A 446
ARG A 103
TYR A 444
 None
 0.75A 2opxA-4pj3A:
undetectable		 2opxA-4pj3A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		3 / 3 ASN A 155
ASN A 456
ARG A1125
 None
 0.79A 2rlcA-4pj3A:
undetectable		 2rlcA-4pj3A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		3 / 3 MET A  92
VAL A  23
GLU A 100
 None
 0.83A 2x9gA-4pj3A:
undetectable		 2x9gA-4pj3A:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 6 LEU A1119
MET A 820
THR A 819
LEU A 818
 None
 0.95A 2zxwA-4pj3A:
undetectable
2zxwJ-4pj3A:
undetectable		 2zxwA-4pj3A:
15.67
2zxwJ-4pj3A:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 7 LEU A1119
MET A 820
THR A 819
LEU A 818
 None
 0.93A 3ablA-4pj3A:
undetectable
3ablJ-4pj3A:
undetectable		 3ablA-4pj3A:
15.67
3ablJ-4pj3A:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 6 LEU A1119
MET A 820
THR A 819
LEU A 818
 None
 0.93A 3abmA-4pj3A:
undetectable
3abmJ-4pj3A:
undetectable		 3abmA-4pj3A:
15.67
3abmJ-4pj3A:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		5 / 12 GLN A 916
PHE A 936
ALA A 932
PHE A 970
ARG A 914
 None
 1.20A 3aobC-4pj3A:
undetectable		 3aobC-4pj3A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		5 / 12 PHE A 123
VAL A 166
ILE A 170
PHE A 253
ALA A 130
 None
 1.34A 3apwA-4pj3A:
undetectable		 3apwA-4pj3A:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 6 LEU A1119
MET A 820
THR A 819
LEU A 818
 None
 0.96A 3asnA-4pj3A:
undetectable
3asnJ-4pj3A:
undetectable		 3asnA-4pj3A:
15.67
3asnJ-4pj3A:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 6 LEU A1119
MET A 820
THR A 819
LEU A 818
 None
 0.94A 3asoA-4pj3A:
undetectable
3asoJ-4pj3A:
undetectable		 3asoA-4pj3A:
15.67
3asoJ-4pj3A:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 7 VAL A 592
VAL A 567
PHE A 583
GLU A 430
 None
 1.27A 3dqrA-4pj3A:
undetectable
3dqrB-4pj3A:
undetectable		 3dqrA-4pj3A:
13.97
3dqrB-4pj3A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 7 PHE A 583
GLU A 430
VAL A 592
VAL A 567
 None
 1.28A 3dqrA-4pj3A:
undetectable
3dqrB-4pj3A:
undetectable		 3dqrA-4pj3A:
13.97
3dqrB-4pj3A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		3 / 3 ASP A1269
LEU A1299
GLN A1136
 None
 0.69A 3g4lA-4pj3A:
undetectable		 3g4lA-4pj3A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 7 PHE A 583
GLU A 430
VAL A 592
VAL A 567
 None
 1.29A 3jx2A-4pj3A:
undetectable
3jx2B-4pj3A:
undetectable		 3jx2A-4pj3A:
13.97
3jx2B-4pj3A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 7 PHE A 583
GLU A 430
VAL A 592
VAL A 567
 None
 1.29A 3jx4A-4pj3A:
undetectable
3jx4B-4pj3A:
2.8		 3jx4A-4pj3A:
13.97
3jx4B-4pj3A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 7 PHE A 583
GLU A 430
VAL A 592
VAL A 567
 None
 1.31A 3jx5A-4pj3A:
undetectable
3jx5B-4pj3A:
undetectable		 3jx5A-4pj3A:
13.97
3jx5B-4pj3A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 7 PHE A 583
GLU A 430
VAL A 592
VAL A 567
 None
 1.30A 3jx6A-4pj3A:
undetectable
3jx6B-4pj3A:
2.8		 3jx6A-4pj3A:
13.24
3jx6B-4pj3A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		3 / 3 SER A1142
ASP A1176
ASN A1170
 None
 0.95A 3lsfB-4pj3A:
undetectable
3lsfE-4pj3A:
undetectable		 3lsfB-4pj3A:
10.71
3lsfE-4pj3A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		3 / 3 ASP A1176
ASN A1170
SER A1142
 None
 0.89A 3lsfB-4pj3A:
undetectable
3lsfE-4pj3A:
undetectable		 3lsfB-4pj3A:
10.71
3lsfE-4pj3A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 6 VAL A 592
VAL A 567
PHE A 583
GLU A 430
 None
 1.32A 3n61A-4pj3A:
undetectable
3n61B-4pj3A:
undetectable		 3n61A-4pj3A:
13.97
3n61B-4pj3A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 7 PHE A 583
GLU A 430
VAL A 592
VAL A 567
 None
 1.32A 3n61A-4pj3A:
undetectable
3n61B-4pj3A:
undetectable		 3n61A-4pj3A:
13.97
3n61B-4pj3A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 7 VAL A 592
VAL A 567
PHE A 583
GLU A 430
 None
 1.28A 3nlpA-4pj3A:
undetectable
3nlpB-4pj3A:
undetectable		 3nlpA-4pj3A:
13.97
3nlpB-4pj3A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 7 PHE A 583
GLU A 430
VAL A 592
VAL A 567
 None
 1.28A 3nlpA-4pj3A:
undetectable
3nlpB-4pj3A:
undetectable		 3nlpA-4pj3A:
13.97
3nlpB-4pj3A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 7 PHE A 583
GLU A 430
VAL A 592
VAL A 567
 None
 1.29A 3nlqA-4pj3A:
undetectable
3nlqB-4pj3A:
undetectable		 3nlqA-4pj3A:
13.97
3nlqB-4pj3A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 7 VAL A 592
VAL A 567
PHE A 583
GLU A 430
 None
 1.28A 3nlrA-4pj3A:
undetectable
3nlrB-4pj3A:
undetectable		 3nlrA-4pj3A:
13.97
3nlrB-4pj3A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 8 GLN A1136
GLY A1137
GLY A1300
ASN A1268
 None
ANP  A1501 ( 3.8A)
None
None
 0.76A 3v3nB-4pj3A:
undetectable		 3v3nB-4pj3A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 8 GLN A1136
GLY A1137
GLY A1300
ASN A1268
 None
ANP  A1501 ( 3.8A)
None
None
 0.76A 3v3nC-4pj3A:
undetectable		 3v3nC-4pj3A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 5 LEU A1273
ALA A1305
THR A1229
PHE A1310
 None
 0.98A 3vasB-4pj3A:
undetectable		 3vasB-4pj3A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 7 HIS A 842
ASP A 872
ARG A 787
HIS A 875
 None
 1.35A 3zodA-4pj3A:
undetectable		 3zodA-4pj3A:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 6 TYR A1112
ARG A 252
GLU A 158
LEU A 148
 None
 1.19A 4ax8A-4pj3A:
2.1		 4ax8A-4pj3A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		5 / 12 LEU A 862
GLY A 828
GLY A1137
ASP A 831
GLY A1095
 None
ANP  A1501 (-3.6A)
ANP  A1501 ( 3.8A)
ANP  A1501 (-3.4A)
None
 0.94A 4blvA-4pj3A:
2.5		 4blvA-4pj3A:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 7 PHE A 583
GLU A 430
VAL A 592
VAL A 567
 None
 1.28A 4cx3A-4pj3A:
undetectable
4cx3B-4pj3A:
undetectable		 4cx3A-4pj3A:
13.97
4cx3B-4pj3A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 7 VAL A 592
VAL A 567
PHE A 583
GLU A 430
 None
 1.27A 4cx4A-4pj3A:
undetectable
4cx4B-4pj3A:
undetectable		 4cx4A-4pj3A:
13.97
4cx4B-4pj3A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 7 PHE A 583
GLU A 430
VAL A 592
VAL A 567
 None
 1.29A 4cx4A-4pj3A:
undetectable
4cx4B-4pj3A:
undetectable		 4cx4A-4pj3A:
13.97
4cx4B-4pj3A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		5 / 12 VAL A1128
ALA A 700
PHE A1073
LEU A1119
ARG A1122
 None
 1.13A 4eckB-4pj3A:
undetectable		 4eckB-4pj3A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		5 / 12 GLY A1202
GLY A1189
VAL A1182
ASN A1357
MET A1358
 None
 1.17A 4f84A-4pj3A:
2.7		 4f84A-4pj3A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		5 / 11 ARG A 194
TRP A 197
LEU A 193
ILE A 313
LEU A 460
 None
 1.04A 4kt0A-4pj3A:
undetectable
4kt0J-4pj3A:
undetectable		 4kt0A-4pj3A:
17.92
4kt0J-4pj3A:
2.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		5 / 11 VAL A1128
ALA A 700
PHE A1073
LEU A1119
ARG A1122
 None
 1.12A 4kyaA-4pj3A:
undetectable		 4kyaA-4pj3A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		5 / 10 VAL A1128
ALA A 700
PHE A1073
LEU A1119
ARG A1122
 None
 1.12A 4kyaC-4pj3A:
undetectable		 4kyaC-4pj3A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		5 / 11 VAL A1128
ALA A 700
PHE A1073
LEU A1119
ARG A1122
 None
 1.12A 4kyaE-4pj3A:
undetectable		 4kyaE-4pj3A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		5 / 11 VAL A1128
ALA A 700
PHE A1073
LEU A1119
ARG A1122
 None
 1.12A 4kyaG-4pj3A:
undetectable		 4kyaG-4pj3A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		5 / 12 ALA A 537
GLY A 594
PHE A 628
ASP A 637
GLU A 430
 None
 1.19A 4pclA-4pj3A:
3.3		 4pclA-4pj3A:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		6 / 12 ILE A 866
LEU A 859
PHE A 863
THR A 849
ILE A1035
THR A 830
 None
None
None
None
None
ANP  A1501 ( 3.9A)
 1.36A 4ptjA-4pj3A:
undetectable		 4ptjA-4pj3A:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 5 ILE A 432
PRO A 428
TYR A 650
VAL A 649
 None
 1.09A 4s0vA-4pj3A:
undetectable		 4s0vA-4pj3A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		3 / 3 ARG A 579
ASP A 578
ARG A 580
 None
 0.53A 4wq4B-4pj3A:
undetectable		 4wq4B-4pj3A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		3 / 3 LYS A 101
ARG A1288
VAL A1287
 None
 1.05A 4x3uA-4pj3A:
undetectable
4x3uB-4pj3A:
undetectable		 4x3uA-4pj3A:
4.24
4x3uB-4pj3A:
4.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 7 PHE A 583
GLU A 430
VAL A 592
VAL A 567
 None
 1.27A 5addA-4pj3A:
undetectable
5addB-4pj3A:
undetectable		 5addA-4pj3A:
13.97
5addB-4pj3A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 7 PHE A 583
GLU A 430
VAL A 592
VAL A 567
 None
 1.30A 5adeA-4pj3A:
undetectable
5adeB-4pj3A:
undetectable		 5adeA-4pj3A:
13.97
5adeB-4pj3A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 7 LEU A1119
MET A 820
THR A 819
LEU A 818
 None
 0.93A 5b1bA-4pj3A:
1.4
5b1bJ-4pj3A:
undetectable		 5b1bA-4pj3A:
15.67
5b1bJ-4pj3A:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 4 LEU A  66
ARG A 103
ILE A  64
ILE A  61
 None
 1.31A 5dzk2-4pj3A:
undetectable
5dzkM-4pj3A:
undetectable
5dzkN-4pj3A:
undetectable		 5dzk2-4pj3A:
4.08
5dzkM-4pj3A:
8.86
5dzkN-4pj3A:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 4 LEU A 564
ILE A 565
GLY A 594
ILE A 485
 None
 0.79A 5dzk3-4pj3A:
undetectable
5dzkm-4pj3A:
undetectable		 5dzk3-4pj3A:
4.08
5dzkm-4pj3A:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 4 ILE A  64
ILE A  61
ARG A 103
LEU A  66
 None
 1.28A 5dzkh-4pj3A:
undetectable
5dzkn-4pj3A:
undetectable
5dzkv-4pj3A:
undetectable		 5dzkh-4pj3A:
8.86
5dzkn-4pj3A:
8.86
5dzkv-4pj3A:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 4 ILE A  64
ILE A  61
ARG A 103
LEU A  67
 None
 1.35A 5dzkh-4pj3A:
undetectable
5dzkn-4pj3A:
undetectable
5dzkv-4pj3A:
undetectable		 5dzkh-4pj3A:
8.86
5dzkn-4pj3A:
8.86
5dzkv-4pj3A:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 5 ILE A 565
GLY A 594
ILE A 485
LEU A 564
 None
 0.77A 5dzkB-4pj3A:
undetectable
5dzkI-4pj3A:
undetectable
5dzkW-4pj3A:
undetectable		 5dzkB-4pj3A:
9.86
5dzkI-4pj3A:
8.86
5dzkW-4pj3A:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 5 ILE A 565
GLY A 594
ILE A 485
LEU A 564
 None
 0.82A 5dzki-4pj3A:
undetectable
5dzkj-4pj3A:
undetectable
5dzkx-4pj3A:
undetectable		 5dzki-4pj3A:
8.86
5dzkj-4pj3A:
8.86
5dzkx-4pj3A:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 5 ILE A 565
GLY A 594
ILE A 485
LEU A 564
 None
 0.82A 5dzkd-4pj3A:
undetectable
5dzkk-4pj3A:
undetectable
5dzky-4pj3A:
undetectable		 5dzkd-4pj3A:
9.86
5dzkk-4pj3A:
8.86
5dzky-4pj3A:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 4 ILE A 565
GLY A 594
ILE A 485
LEU A 564
 None
 0.81A 5dzkl-4pj3A:
undetectable
5dzkz-4pj3A:
undetectable		 5dzkl-4pj3A:
8.86
5dzkz-4pj3A:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 7 PHE A 583
GLU A 430
VAL A 592
VAL A 567
 None
 1.30A 5g0pA-4pj3A:
undetectable
5g0pB-4pj3A:
undetectable		 5g0pA-4pj3A:
13.97
5g0pB-4pj3A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		3 / 3 TRP A 175
GLU A 186
ASP A 315
 None
 1.01A 5gqbA-4pj3A:
undetectable		 5gqbA-4pj3A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		5 / 12 VAL A1050
GLN A1079
LEU A 850
LEU A 466
ILE A 691
 None
 1.19A 5hv1A-4pj3A:
3.7		 5hv1A-4pj3A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		5 / 12 THR A1229
ALA A1139
SER A1225
ILE A1224
MET A1214
 None
 1.35A 5iwuA-4pj3A:
undetectable		 5iwuA-4pj3A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 7 LEU A1119
MET A 820
THR A 819
LEU A 818
 None
 0.93A 5iy5A-4pj3A:
undetectable
5iy5J-4pj3A:
undetectable		 5iy5A-4pj3A:
15.67
5iy5J-4pj3A:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 4 LEU A1227
MET A1294
ILE A1237
LEU A1275
 None
 1.33A 5nfpA-4pj3A:
undetectable		 5nfpA-4pj3A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 8 PHE A 802
THR A 819
ILE A 810
GLY A 813
 None
 1.00A 5nzxA-4pj3A:
3.7		 5nzxA-4pj3A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 7 PHE A 802
THR A 819
ILE A 810
GLY A 813
 None
 1.01A 5nzyA-4pj3A:
2.1		 5nzyA-4pj3A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		3 / 3 VAL A1276
TYR A1198
GLN A1199
 None
 0.75A 5qgkA-4pj3A:
undetectable		 5qgkA-4pj3A:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		3 / 3 VAL A1276
TYR A1198
GLN A1199
 None
 0.73A 5qgtA-4pj3A:
undetectable		 5qgtA-4pj3A:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 5 ASN A 314
ASP A 315
ASN A 271
ASP A 275
 None
 1.23A 5vooA-4pj3A:
3.1		 5vooA-4pj3A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 5 ASN A 314
ASP A 315
ASN A 271
ASP A 275
 None
 1.23A 5vooC-4pj3A:
undetectable		 5vooC-4pj3A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 6 LEU A1119
MET A 820
THR A 819
LEU A 818
 None
 1.01A 5x1fA-4pj3A:
undetectable
5x1fJ-4pj3A:
undetectable		 5x1fA-4pj3A:
15.67
5x1fJ-4pj3A:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 6 HIS A 330
ASN A 355
VAL A 359
LEU A 365
 None
 1.41A 5xdhA-4pj3A:
undetectable
5xdhC-4pj3A:
undetectable		 5xdhA-4pj3A:
4.98
5xdhC-4pj3A:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 8 LEU A1119
MET A 820
THR A 819
LEU A 818
 None
 0.92A 5zcoA-4pj3A:
1.4
5zcoJ-4pj3A:
undetectable		 5zcoA-4pj3A:
15.67
5zcoJ-4pj3A:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		5 / 12 ILE A  35
VAL A1281
ALA A  32
PHE A1320
LEU A1179
 None
 1.33A 6a7pB-4pj3A:
undetectable		 6a7pB-4pj3A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 4 ILE A  94
LEU A 146
HIS A 125
ALA A 129
 None
 0.79A 6ck2C-4pj3A:
undetectable
6ck2D-4pj3A:
undetectable		 6ck2C-4pj3A:
1.60
6ck2D-4pj3A:
1.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		4 / 6 ARG A 811
PHE A 751
VAL A 753
PRO A 752
 None
 1.32A 6fgdA-4pj3A:
undetectable		 6fgdA-4pj3A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens) 		5 / 12 ILE A1094
ALA A1042
LEU A 862
ARG A 878
LEU A 850
 None
 1.26A 6ie8A-4pj3A:
1.4		 6ie8A-4pj3A:
9.45