SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pju'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 4pju COHESIN SUBUNIT SA-2
(Homo
sapiens) 		3 / 3 ALA A 998
VAL A1037
TRP A1038
 None
 0.79A 1c4dA-4pjuA:
undetectable
1c4dB-4pjuA:
undetectable		 1c4dA-4pjuA:
1.84
1c4dB-4pjuA:
1.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4pju COHESIN SUBUNIT SA-2
(Homo
sapiens) 		4 / 5 ARG A 246
ASP A 321
SER A 320
SER A 238
 None
 1.45A 1kiaB-4pjuA:
undetectable		 1kiaB-4pjuA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4pju COHESIN SUBUNIT SA-2
(Homo
sapiens) 		4 / 6 ARG A 246
ASP A 321
SER A 320
SER A 238
 None
 1.45A 1kiaC-4pjuA:
undetectable		 1kiaC-4pjuA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4pju COHESIN SUBUNIT SA-2
DOUBLE-STRAND-BREAK
REPAIR PROTEIN RAD21
HOMOLOG
(Homo
sapiens;
Homo
sapiens) 		4 / 5 ASP A 381
VAL B 348
SER A 377
ASP A 338
 None
 1.40A 1n2xB-4pjuA:
undetectable		 1n2xB-4pjuA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4pju COHESIN SUBUNIT SA-2
(Homo
sapiens) 		4 / 7 PHE A 367
LEU A 393
MET A 316
MET A 318
 None
 1.18A 1wrlE-4pjuA:
undetectable		 1wrlE-4pjuA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 4pju COHESIN SUBUNIT SA-2
DOUBLE-STRAND-BREAK
REPAIR PROTEIN RAD21
HOMOLOG
(Homo
sapiens) 		4 / 4 LEU A 825
PRO B 376
ILE A 794
LEU A 795
 None
 0.95A 1ya4B-4pjuA:
undetectable		 1ya4B-4pjuA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 4pju COHESIN SUBUNIT SA-2
DOUBLE-STRAND-BREAK
REPAIR PROTEIN RAD21
HOMOLOG
(Homo
sapiens) 		4 / 4 LEU A 825
PRO B 376
ILE A 794
LEU A 795
 None
 0.96A 1ya4C-4pjuA:
undetectable		 1ya4C-4pjuA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 4pju COHESIN SUBUNIT SA-2
(Homo
sapiens) 		4 / 4 LEU A 810
SER A 753
LEU A 761
LEU A 745
 None
 1.17A 1yajA-4pjuA:
undetectable		 1yajA-4pjuA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4pju COHESIN SUBUNIT SA-2
DOUBLE-STRAND-BREAK
REPAIR PROTEIN RAD21
HOMOLOG
(Homo
sapiens;
Homo
sapiens) 		5 / 12 LEU B 351
LEU A 473
SER A 471
ALA A 428
ALA A 427
 None
 1.18A 2bm9D-4pjuB:
undetectable		 2bm9D-4pjuB:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 4pju COHESIN SUBUNIT SA-2
(Homo
sapiens) 		4 / 8 THR A 718
VAL A 730
PHE A 672
ALA A 684
 None
 1.13A 2ij7C-4pjuA:
undetectable		 2ij7C-4pjuA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 4pju COHESIN SUBUNIT SA-2
DOUBLE-STRAND-BREAK
REPAIR PROTEIN RAD21
HOMOLOG
(Homo
sapiens) 		4 / 8 HIS A 421
ALA A 425
VAL A 424
LEU B 351
 None
 0.73A 2it4A-4pjuA:
undetectable		 2it4A-4pjuA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 4pju COHESIN SUBUNIT SA-2
(Homo
sapiens) 		5 / 11 LEU A 588
LEU A 574
ILE A 522
ASP A 515
ASP A 581
 None
 1.27A 2q6hA-4pjuA:
undetectable		 2q6hA-4pjuA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 4pju COHESIN SUBUNIT SA-2
(Homo
sapiens) 		5 / 11 LEU A 588
LEU A 574
ILE A 522
ASP A 515
ASP A 581
 None
 1.27A 2qeiA-4pjuA:
undetectable		 2qeiA-4pjuA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4pju COHESIN SUBUNIT SA-2
(Homo
sapiens) 		5 / 10 ALA A 350
LEU A 324
LEU A 354
LEU A 329
ARG A 370
 None
 1.08A 2riwA-4pjuA:
undetectable
2riwB-4pjuA:
undetectable		 2riwA-4pjuA:
16.07
2riwB-4pjuA:
3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 4pju COHESIN SUBUNIT SA-2
(Homo
sapiens) 		5 / 12 LEU A 776
ILE A 829
THR A 881
VAL A 877
LEU A 871
 None
 1.26A 3a51B-4pjuA:
2.4		 3a51B-4pjuA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4pju COHESIN SUBUNIT SA-2
(Homo
sapiens) 		5 / 12 LEU A 589
LEU A 657
LEU A 609
LEU A 597
TYR A 600
 None
 1.39A 3adsA-4pjuA:
undetectable		 3adsA-4pjuA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4pju COHESIN SUBUNIT SA-2
DOUBLE-STRAND-BREAK
REPAIR PROTEIN RAD21
HOMOLOG
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ARG A 305
GLU A 303
ARG A 213
ASP B 327
 None
 1.21A 4kcnA-4pjuA:
undetectable		 4kcnA-4pjuA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4pju COHESIN SUBUNIT SA-2
DOUBLE-STRAND-BREAK
REPAIR PROTEIN RAD21
HOMOLOG
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ARG A 305
GLU A 303
ARG A 213
ASP B 327
 None
 1.23A 4kcnB-4pjuA:
undetectable		 4kcnB-4pjuA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 4pju COHESIN SUBUNIT SA-2
(Homo
sapiens) 		5 / 12 LEU A 204
LEU A 182
ILE A 179
ILE A 288
PHE A 121
 None
 0.98A 4odrA-4pjuA:
undetectable
4odrB-4pjuA:
undetectable		 4odrA-4pjuA:
7.97
4odrB-4pjuA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 4pju COHESIN SUBUNIT SA-2
(Homo
sapiens) 		5 / 11 LEU A 204
LEU A 182
ILE A 179
ILE A 288
PHE A 121
 None
 1.02A 4odrA-4pjuA:
undetectable
4odrB-4pjuA:
undetectable		 4odrA-4pjuA:
7.97
4odrB-4pjuA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 4pju COHESIN SUBUNIT SA-2
(Homo
sapiens) 		5 / 12 VAL A 376
HIS A 337
ALA A 390
LEU A 351
GLY A 333
 None
 1.29A 4qckA-4pjuA:
undetectable		 4qckA-4pjuA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 4pju COHESIN SUBUNIT SA-2
(Homo
sapiens) 		5 / 12 ASN A 499
PHE A 567
LEU A 574
TYR A 578
LEU A 521
 None
 1.17A 4zbrA-4pjuA:
2.6		 4zbrA-4pjuA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_NPSA602_1
(SERUM ALBUMIN)		 4pju COHESIN SUBUNIT SA-2
(Homo
sapiens) 		5 / 12 ASN A 499
PHE A 567
LEU A 574
TYR A 578
LEU A 521
 None
 1.21A 5dbyA-4pjuA:
undetectable		 5dbyA-4pjuA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4pju COHESIN SUBUNIT SA-2
(Homo
sapiens) 		5 / 12 ALA A 857
PHE A 768
ILE A 771
TYR A 775
THR A 695
 None
 1.17A 5eshA-4pjuA:
undetectable		 5eshA-4pjuA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 4pju COHESIN SUBUNIT SA-2
DOUBLE-STRAND-BREAK
REPAIR PROTEIN RAD21
HOMOLOG
(Homo
sapiens) 		5 / 12 LEU A 825
PHE A 828
ILE A 899
ALA B 377
LEU B 372
 None
 1.20A 5ienA-4pjuA:
undetectable		 5ienA-4pjuA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4pju COHESIN SUBUNIT SA-2
(Homo
sapiens) 		5 / 12 ALA A 857
PHE A 768
ILE A 771
TYR A 775
THR A 695
 None
 1.27A 5jlcA-4pjuA:
undetectable		 5jlcA-4pjuA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 4pju COHESIN SUBUNIT SA-2
(Homo
sapiens) 		5 / 12 GLN A 269
LEU A 267
LEU A 266
GLU A 265
LEU A 264
 None
 1.24A 5nwwA-4pjuA:
undetectable		 5nwwA-4pjuA:
3.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDM_A_ADNA904_1
(ATP-CITRATE SYNTHASE)		 4pju COHESIN SUBUNIT SA-2
(Homo
sapiens) 		4 / 4 THR A 561
ASP A 596
ARG A 560
LEU A 557
 None
 1.44A 5tdmA-4pjuA:
undetectable		 5tdmA-4pjuA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4pju COHESIN SUBUNIT SA-2
DOUBLE-STRAND-BREAK
REPAIR PROTEIN RAD21
HOMOLOG
(Homo
sapiens) 		4 / 8 TRP B 381
THR A 626
THR A 586
GLN A 590
 None
 1.42A 5tzoA-4pjuB:
undetectable		 5tzoA-4pjuB:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4pju COHESIN SUBUNIT SA-2
DOUBLE-STRAND-BREAK
REPAIR PROTEIN RAD21
HOMOLOG
(Homo
sapiens) 		4 / 8 TRP B 381
THR A 626
THR A 586
GLN A 590
 None
 1.33A 5tzoB-4pjuB:
undetectable		 5tzoB-4pjuB:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4pju COHESIN SUBUNIT SA-2
DOUBLE-STRAND-BREAK
REPAIR PROTEIN RAD21
HOMOLOG
(Homo
sapiens) 		4 / 8 TRP B 381
THR A 626
THR A 586
GLN A 590
 None
 1.39A 5tzoC-4pjuB:
undetectable		 5tzoC-4pjuB:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4pju COHESIN SUBUNIT SA-2
(Homo
sapiens) 		5 / 12 PHE A 175
LEU A 117
GLY A 180
THR A 228
LEU A 221
 None
 1.20A 5x24A-4pjuA:
undetectable		 5x24A-4pjuA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4pju COHESIN SUBUNIT SA-2
DOUBLE-STRAND-BREAK
REPAIR PROTEIN RAD21
HOMOLOG
(Homo
sapiens;
Homo
sapiens) 		5 / 12 VAL A 376
SER A 377
THR A 379
ALA A 390
TYR B 344
 None
 1.32A 6drxA-4pjuA:
2.5		 6drxA-4pjuA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 4pju COHESIN SUBUNIT SA-2
(Homo
sapiens) 		3 / 3 TYR A 636
HIS A 701
PHE A 697
 None
 0.90A 6esmA-4pjuA:
undetectable		 6esmA-4pjuA:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 4pju COHESIN SUBUNIT SA-2
(Homo
sapiens) 		4 / 6 ASN A 412
VAL A 376
LYS A 372
THR A 406
 None
 1.37A 6f32B-4pjuA:
undetectable		 6f32B-4pjuA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4pju COHESIN SUBUNIT SA-2
(Homo
sapiens) 		4 / 8 PRO A1040
ASP A1001
SER A 946
PHE A 945
 None
 1.22A 6fcbA-4pjuA:
undetectable		 6fcbA-4pjuA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 4pju COHESIN SUBUNIT SA-2
(Homo
sapiens) 		5 / 12 ARG A 184
VAL A 183
ILE A 191
ASN A 236
ILE A 281
 None
 1.42A 6gsdA-4pjuA:
undetectable		 6gsdA-4pjuA:
5.90