SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pk1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB
(Escherichia
coli) 		5 / 9 VAL A1081
LEU A1134
ALA A1109
SER A1126
LEU A1111
 None
 1.19A 1eqgA-4pk1A:
undetectable		 1eqgA-4pk1A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB
(Escherichia
coli) 		5 / 12 VAL A 258
LEU A 226
SER A 228
LEU A 231
THR A 243
 None
 1.10A 1kw0A-4pk1A:
undetectable		 1kw0A-4pk1A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB
(Escherichia
coli) 		4 / 8 ILE A1349
PHE A1356
ARG A1304
LEU A1327
 None
 0.92A 2eikN-4pk1A:
undetectable
2eikW-4pk1A:
undetectable		 2eikN-4pk1A:
21.54
2eikW-4pk1A:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB
(Escherichia
coli) 		4 / 8 ILE A1349
PHE A1356
ARG A1304
LEU A1327
 None
 0.92A 2eilN-4pk1A:
undetectable
2eilW-4pk1A:
undetectable		 2eilN-4pk1A:
21.54
2eilW-4pk1A:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB
(Escherichia
coli) 		5 / 12 ALA A1075
GLY A1057
ASP A1076
LEU A1063
SER A1061
 None
 1.34A 2nv4A-4pk1A:
undetectable		 2nv4A-4pk1A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB
(Escherichia
coli) 		4 / 8 ILE A1349
PHE A1356
ARG A1304
LEU A1327
 None
 0.95A 3asnN-4pk1A:
undetectable
3asnW-4pk1A:
undetectable		 3asnN-4pk1A:
21.54
3asnW-4pk1A:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB
(Escherichia
coli) 		5 / 11 GLY A1179
ASP A1178
ALA A1177
ALA A1133
ALA A1173
 None
 1.11A 3g88A-4pk1A:
undetectable		 3g88A-4pk1A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB
(Escherichia
coli) 		3 / 3 LEU A1323
MET A1032
ASP A 250
 None
 0.90A 3v5wA-4pk1A:
2.9		 3v5wA-4pk1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB
(Escherichia
coli) 		5 / 11 GLY A1344
ASP A1363
ALA A1382
GLY A1366
VAL A1362
 None
 1.20A 4c5lA-4pk1A:
undetectable		 4c5lA-4pk1A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB
(Escherichia
coli) 		5 / 9 GLY A1344
ASP A1363
ALA A1382
GLY A1366
VAL A1362
 None
 1.21A 4c5lB-4pk1A:
undetectable		 4c5lB-4pk1A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB
(Escherichia
coli) 		5 / 10 GLY A1344
ASP A1363
ALA A1382
GLY A1366
VAL A1362
 None
 1.21A 4c5lD-4pk1A:
undetectable		 4c5lD-4pk1A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB
(Escherichia
coli) 		5 / 10 GLY A1344
ASP A1363
ALA A1382
GLY A1366
VAL A1362
 None
 1.20A 4c5nB-4pk1A:
undetectable		 4c5nB-4pk1A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB
(Escherichia
coli) 		5 / 10 GLY A1344
ASP A1363
ALA A1382
GLY A1366
VAL A1362
 None
 1.25A 4c5nD-4pk1A:
undetectable		 4c5nD-4pk1A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_C_ACTC506_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB
(Escherichia
coli) 		4 / 5 ARG A1273
ILE A1227
TRP A1228
GLY A1275
 None
 1.39A 4e7cC-4pk1A:
undetectable		 4e7cC-4pk1A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB
(Escherichia
coli) 		5 / 12 ASN A 185
ALA A1129
SER A1126
GLN A 179
TYR A1132
 None
 1.38A 4ejwA-4pk1A:
undetectable		 4ejwA-4pk1A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB
(Escherichia
coli) 		5 / 12 LEU A1110
GLY A1125
VAL A1141
LEU A1097
VAL A1095
 None
 1.01A 4gc9A-4pk1A:
undetectable		 4gc9A-4pk1A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB
(Escherichia
coli) 		3 / 4 SER A1329
GLY A1113
GLU A1150
 None
 0.56A 4juoA-4pk1A:
undetectable
4juoC-4pk1A:
undetectable		 4juoA-4pk1A:
23.34
4juoC-4pk1A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA207_0
(OXIDOREDUCTASE)		 4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB
(Escherichia
coli) 		4 / 4 GLU A1343
GLY A1344
HIS A1347
ARG A1325
 None
 0.85A 4r82A-4pk1A:
undetectable
4r82B-4pk1A:
undetectable		 4r82A-4pk1A:
13.84
4r82B-4pk1A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB
(Escherichia
coli) 		4 / 7 ILE A1349
PHE A1356
ARG A1304
LEU A1327
 None
 0.87A 5b1bN-4pk1A:
undetectable
5b1bW-4pk1A:
undetectable		 5b1bN-4pk1A:
21.54
5b1bW-4pk1A:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_A_ACTA202_0
(NITROGEN REGULATORY
PROTEIN P-II)		 4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB
(Escherichia
coli) 		4 / 4 VAL A1115
GLY A1114
ARG A1154
VAL A1117
 None
 1.19A 5d4nA-4pk1A:
undetectable
5d4nB-4pk1A:
undetectable		 5d4nA-4pk1A:
10.20
5d4nB-4pk1A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB
(Escherichia
coli) 		3 / 3 TRP A1279
ARG A1281
LEU A1261
 None
 0.92A 5dbyA-4pk1A:
undetectable		 5dbyA-4pk1A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB
(Escherichia
coli) 		4 / 6 ALA A1133
VAL A1131
VAL A1157
HIS A1121
 None
 1.01A 5eckA-4pk1A:
undetectable		 5eckA-4pk1A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB
(Escherichia
coli) 		4 / 6 ALA A1133
VAL A1131
VAL A1157
HIS A1121
 None
 1.01A 5eckD-4pk1A:
undetectable		 5eckD-4pk1A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB
(Escherichia
coli) 		5 / 12 ILE A1390
ALA A1075
ALA A1074
VAL A1072
GLY A1053
 None
 1.10A 5igjA-4pk1A:
undetectable		 5igjA-4pk1A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB
(Escherichia
coli) 		5 / 12 GLY A1057
ASN A1062
LEU A1111
GLU A1127
LEU A1110
 None
 1.21A 5nwwA-4pk1A:
undetectable		 5nwwA-4pk1A:
4.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB
(Escherichia
coli) 		4 / 8 GLY A1366
ARG A1325
ASP A1341
TYR A1345
 None
 1.07A 5vlmA-4pk1A:
undetectable		 5vlmA-4pk1A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB
(Escherichia
coli) 		5 / 12 VAL A1258
PRO A1251
THR A1250
THR A1116
SER A1153
 None
 1.28A 5xiqC-4pk1A:
undetectable		 5xiqC-4pk1A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB
(Escherichia
coli) 		4 / 8 ILE A1349
PHE A1356
ARG A1304
LEU A1327
 None
 0.89A 5zcqN-4pk1A:
undetectable
5zcqW-4pk1A:
undetectable		 5zcqN-4pk1A:
21.54
5zcqW-4pk1A:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB
(Escherichia
coli) 		5 / 12 LEU A1171
VAL A1185
GLY A1224
TRP A1228
VAL A1216
 None
 1.24A 6a94A-4pk1A:
undetectable		 6a94A-4pk1A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB
(Escherichia
coli) 		5 / 9 SER A1285
VAL A1247
SER A1245
VAL A1286
GLY A1265
 None
 1.22A 6bklA-4pk1A:
undetectable
6bklB-4pk1A:
undetectable
6bklC-4pk1A:
undetectable
6bklD-4pk1A:
undetectable		 6bklA-4pk1A:
3.45
6bklB-4pk1A:
3.45
6bklC-4pk1A:
3.45
6bklD-4pk1A:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB
(Escherichia
coli) 		5 / 12 LEU A1063
VAL A1162
THR A1145
VAL A1147
ALA A1109
 None
 1.22A 6djzA-4pk1A:
undetectable		 6djzA-4pk1A:
17.38