SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pka'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		5 / 11 PHE X 114
GLY X  36
THR X 260
ASP X 332
ILE X  39
 None
MIS  X  77 ( 3.4A)
None
None
None
 1.16A 1phgA-4pkaX:
undetectable		 1phgA-4pkaX:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		5 / 10 GLY X 261
ILE X  34
GLY X  38
ILE X  39
ALA X  45
 None
None
MIS  X  77 ( 3.4A)
None
None
 1.00A 1sh9B-4pkaX:
undetectable		 1sh9B-4pkaX:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		5 / 12 THR X 187
ILE X  73
ILE X 152
THR X 148
PHE X  70
 MIS  X  77 ( 3.0A)
None
None
None
None
 1.43A 1vq1A-4pkaX:
2.0		 1vq1A-4pkaX:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 4pka PATATIN-17
(Solanum
cardiophyllum) 		4 / 7 ALA X 190
TYR X 193
TYR X 106
PHE X 114
 MIS  X  77 ( 3.5A)
MIS  X  77 ( 4.9A)
None
None
 0.98A 2ajvH-4pkaX:
undetectable
2ajvL-4pkaX:
undetectable		 2ajvH-4pkaX:
21.51
2ajvL-4pkaX:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		3 / 3 PRO X 191
THR X 192
PRO X 123
 None
 0.84A 2d55C-4pkaX:
undetectable		 2d55C-4pkaX:
3.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		5 / 9 GLY X 346
GLU X 321
ILE X  42
ALA X  45
VAL X 103
 None
 1.36A 2drdA-4pkaX:
undetectable		 2drdA-4pkaX:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		4 / 7 THR X 299
SER X 257
SER X  33
VAL X  31
 None
 0.95A 2hdnE-4pkaX:
undetectable
2hdnF-4pkaX:
undetectable
2hdnH-4pkaX:
undetectable		 2hdnE-4pkaX:
8.52
2hdnF-4pkaX:
22.72
2hdnH-4pkaX:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		4 / 7 SER X  33
VAL X  31
THR X 299
SER X 257
 None
 0.99A 2hdnF-4pkaX:
undetectable
2hdnG-4pkaX:
undetectable
2hdnH-4pkaX:
undetectable		 2hdnF-4pkaX:
22.72
2hdnG-4pkaX:
8.52
2hdnH-4pkaX:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		4 / 6 THR X 299
SER X 257
SER X  33
VAL X  31
 None
 1.01A 2hdnI-4pkaX:
undetectable
2hdnJ-4pkaX:
undetectable
2hdnL-4pkaX:
undetectable		 2hdnI-4pkaX:
8.52
2hdnJ-4pkaX:
22.72
2hdnL-4pkaX:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		4 / 6 SER X  33
VAL X  31
THR X 299
SER X 257
 None
 0.91A 2hdnJ-4pkaX:
undetectable
2hdnK-4pkaX:
undetectable
2hdnL-4pkaX:
undetectable		 2hdnJ-4pkaX:
22.72
2hdnK-4pkaX:
8.52
2hdnL-4pkaX:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		4 / 6 LEU X  48
LEU X  51
ILE X  86
ARG X  65
 None
 0.96A 2rlfA-4pkaX:
undetectable
2rlfB-4pkaX:
undetectable		 2rlfA-4pkaX:
7.99
2rlfB-4pkaX:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		4 / 8 LEU X  66
LEU X 366
LYS X 367
LEU X 373
 None
 0.77A 2xn3A-4pkaX:
undetectable
2xn3B-4pkaX:
undetectable		 2xn3A-4pkaX:
21.74
2xn3B-4pkaX:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		5 / 12 SER X 153
MET X 253
ILE X 245
PHE X 307
ASP X  35
 MIS  X  77 ( 4.7A)
None
None
None
None
 1.36A 3aocC-4pkaX:
undetectable		 3aocC-4pkaX:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		5 / 11 ASN X 338
GLY X  37
ILE X  43
THR X 328
LEU X 324
 None
MIS  X  77 ( 3.5A)
None
None
None
 1.29A 3bf1E-4pkaX:
undetectable
3bf1F-4pkaX:
undetectable		 3bf1E-4pkaX:
20.31
3bf1F-4pkaX:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		4 / 4 THR X 148
VAL X 231
GLY X  75
THR X  76
 None
None
None
MIS  X  77 ( 3.8A)
 1.08A 3cflA-4pkaX:
undetectable		 3cflA-4pkaX:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		4 / 6 ALA X  84
LEU X  81
THR X  83
VAL X 150
 None
MIS  X  77 ( 4.0A)
None
None
 1.06A 3d2tB-4pkaX:
undetectable		 3d2tB-4pkaX:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		4 / 7 ALA X  84
LEU X  81
THR X  83
VAL X 150
 None
MIS  X  77 ( 4.0A)
None
None
 1.00A 3ozkB-4pkaX:
undetectable		 3ozkB-4pkaX:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		5 / 11 LEU X 317
LEU X  32
LEU X  48
ILE X  47
LEU X  51
 None
 0.96A 4odrA-4pkaX:
undetectable
4odrB-4pkaX:
undetectable		 4odrA-4pkaX:
14.67
4odrB-4pkaX:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		5 / 12 GLY X  80
TYR X 185
ILE X  34
ILE X  73
SER X  33
 MIS  X  77 ( 3.2A)
None
None
None
None
 1.30A 4xudA-4pkaX:
undetectable		 4xudA-4pkaX:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		5 / 10 PHE X 105
VAL X 133
GLU X 136
LEU X 134
PHE X  96
 None
 1.28A 4zmeB-4pkaX:
undetectable		 4zmeB-4pkaX:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		5 / 12 ALA X 222
GLY X  79
GLY X  36
GLY X 259
ALA X 188
 None
MIS  X  77 ( 4.1A)
MIS  X  77 ( 3.4A)
None
MIS  X  77 ( 3.4A)
 1.01A 5c0oE-4pkaX:
undetectable		 5c0oE-4pkaX:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		3 / 3 THR X  76
THR X 187
PHE X 155
 MIS  X  77 ( 3.8A)
MIS  X  77 ( 3.0A)
None
 0.76A 5cxvA-4pkaX:
undetectable		 5cxvA-4pkaX:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		5 / 11 PHE X 165
ILE X 164
LEU X 226
GLY X  74
ALA X 232
 None
 1.09A 5fctA-4pkaX:
undetectable		 5fctA-4pkaX:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		3 / 3 ARG X 380
THR X  30
ASP X  71
 None
 0.79A 5g5gA-4pkaX:
undetectable
5g5gB-4pkaX:
undetectable		 5g5gA-4pkaX:
20.68
5g5gB-4pkaX:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		5 / 12 ILE X 102
ALA X 189
ALA X 188
GLY X 127
TYR X 129
 None
None
MIS  X  77 ( 3.4A)
None
None
 0.83A 5igpA-4pkaX:
undetectable		 5igpA-4pkaX:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		5 / 12 ILE X 102
ALA X 189
ALA X 188
GLY X 127
TYR X 129
 None
None
MIS  X  77 ( 3.4A)
None
None
 0.85A 5igtA-4pkaX:
undetectable		 5igtA-4pkaX:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		6 / 12 GLY X  38
PHE X 194
VAL X 133
THR X  83
GLY X  80
GLY X  79
 MIS  X  77 ( 3.4A)
MIS  X  77 ( 4.6A)
None
None
MIS  X  77 ( 3.2A)
MIS  X  77 ( 4.1A)
 1.29A 5koxA-4pkaX:
undetectable		 5koxA-4pkaX:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		5 / 12 VAL X 218
ALA X 222
PRO X 196
ALA X 217
GLY X 216
 None
 1.33A 5tzoA-4pkaX:
undetectable		 5tzoA-4pkaX:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		5 / 12 VAL X 218
ALA X 222
PRO X 196
ALA X 217
GLY X 216
 None
 1.32A 5tzoC-4pkaX:
undetectable		 5tzoC-4pkaX:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		4 / 5 LEU X 366
LYS X 367
ALA X 370
LEU X 373
 None
 0.66A 5vkqA-4pkaX:
undetectable
5vkqD-4pkaX:
undetectable		 5vkqA-4pkaX:
11.99
5vkqD-4pkaX:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		4 / 5 LEU X 366
LYS X 367
ALA X 370
LEU X 373
 None
 0.66A 5vkqA-4pkaX:
undetectable
5vkqB-4pkaX:
undetectable		 5vkqA-4pkaX:
11.99
5vkqB-4pkaX:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		4 / 5 LEU X 366
LYS X 367
ALA X 370
LEU X 373
 None
 0.65A 5vkqB-4pkaX:
undetectable
5vkqC-4pkaX:
undetectable		 5vkqB-4pkaX:
11.99
5vkqC-4pkaX:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		4 / 5 LEU X 366
LYS X 367
ALA X 370
LEU X 373
 None
 0.66A 5vkqC-4pkaX:
undetectable
5vkqD-4pkaX:
undetectable		 5vkqC-4pkaX:
11.99
5vkqD-4pkaX:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		4 / 6 GLN X 112
MET X 131
ASN X 115
LEU X 134
 None
 1.28A 5xdhA-4pkaX:
undetectable
5xdhC-4pkaX:
undetectable		 5xdhA-4pkaX:
15.18
5xdhC-4pkaX:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		4 / 5 GLU X 108
HIS X 109
LEU X 134
VAL X 133
 None
 1.17A 6bc9A-4pkaX:
undetectable		 6bc9A-4pkaX:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 4pka PATATIN-17
(Solanum
cardiophyllum) 		5 / 12 PHE X 165
ILE X 164
LEU X 226
GLY X  74
ALA X 232
 None
 1.10A 6r2eE-4pkaX:
undetectable		 6r2eE-4pkaX:
22.44