SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pkd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4pkd U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
A,U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN 70
KDA
(Homo
sapiens;
Sus
scrofa) 		5 / 8 ILE B  12
ALA B  55
LEU B  17
ILE B  84
PHE B  34
 None
 1.28A 2w9sE-4pkdB:
undetectable		 2w9sE-4pkdB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4pkd U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
A,U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN 70
KDA
(Homo
sapiens;
Sus
scrofa) 		5 / 12 ILE B  21
LEU B  30
ALA B  32
ILE B  33
PHE B  77
 None
 0.89A 3b2rA-4pkdB:
undetectable		 3b2rA-4pkdB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4pkd U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
A,U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN 70
KDA
(Homo
sapiens;
Sus
scrofa) 		5 / 11 ILE B  21
LEU B  30
ALA B  32
ILE B  33
PHE B  77
 None
 0.87A 3b2rB-4pkdB:
undetectable		 3b2rB-4pkdB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 4pkd U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
A,U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN 70
KDA
(Homo
sapiens;
Sus
scrofa) 		3 / 3 ARG B 136
LYS B 135
LYS B 139
 G  V 103 ( 3.2A)
None
G  V 102 ( 2.7A)
 1.41A 4k50A-4pkdB:
2.6		 4k50A-4pkdB:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 4pkd U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
A,U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN 70
KDA
(Homo
sapiens;
Sus
scrofa) 		3 / 3 ARG B 136
LYS B 135
LYS B 139
 G  V 103 ( 3.2A)
None
G  V 102 ( 2.7A)
 1.24A 4k50E-4pkdB:
undetectable		 4k50E-4pkdB:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 4pkd U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
A,U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN 70
KDA
(Homo
sapiens;
Sus
scrofa) 		3 / 3 TYR B 226
ASP B 230
ASP B 242
 None
None
U  V  95 ( 3.8A)
 0.84A 5x6yA-4pkdB:
undetectable		 5x6yA-4pkdB:
17.36