SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pke'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 4pke PROTEIN C10C5.1,
ISOFORM I
(Caenorhabditis
elegans) 		4 / 7 GLY A 250
ASP A 225
HIS A 248
ALA A 181
 None
 1.00A 1gxsA-4pkeA:
undetectable
1gxsB-4pkeA:
undetectable		 1gxsA-4pkeA:
21.97
1gxsB-4pkeA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 4pke PROTEIN C10C5.1,
ISOFORM I
(Caenorhabditis
elegans) 		4 / 5 GLY A 250
PRO A 249
ILE A 201
ILE A 202
 None
 0.81A 2q9rA-4pkeA:
undetectable		 2q9rA-4pkeA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4pke PROTEIN C10C5.1,
ISOFORM I
(Caenorhabditis
elegans) 		3 / 3 ASN A 109
ARG A 108
ASP A 168
 None
 0.96A 2qe6A-4pkeA:
undetectable		 2qe6A-4pkeA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4pke PROTEIN C10C5.1,
ISOFORM I
(Caenorhabditis
elegans) 		3 / 3 ASN A 109
ARG A 108
ASP A 168
 None
 0.96A 2qe6B-4pkeA:
undetectable		 2qe6B-4pkeA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4pke PROTEIN C10C5.1,
ISOFORM I
(Caenorhabditis
elegans) 		3 / 3 GLN A  34
GLU A  14
LYS A  14
 None
 1.15A 3su9A-4pkeA:
undetectable		 3su9A-4pkeA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 4pke PROTEIN C10C5.1,
ISOFORM I
(Caenorhabditis
elegans) 		5 / 9 LEU A 193
LEU A 256
SER A 196
THR A 200
ILE A 201
 None
 1.07A 4ubsA-4pkeA:
undetectable		 4ubsA-4pkeA:
21.05