SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pki'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 4pki GELSOLIN,TROPOMODULI
N-1 CHIMERA
(Homo
sapiens) 		3 / 3 VAL G  96
VAL G  73
TRP G  71
 None
 0.70A 1av2C-4pkiG:
undetectable
1av2D-4pkiG:
undetectable		 1av2C-4pkiG:
8.47
1av2D-4pkiG:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 4pki GELSOLIN,TROPOMODULI
N-1 CHIMERA
(Homo
sapiens) 		3 / 3 VAL G  96
VAL G  73
TRP G  71
 None
 0.77A 1w5uC-4pkiG:
undetectable
1w5uD-4pkiG:
undetectable		 1w5uC-4pkiG:
8.47
1w5uD-4pkiG:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4pki GELSOLIN,TROPOMODULI
N-1 CHIMERA
(Homo
sapiens) 		4 / 4 HIS G 113
ASP G 136
ASN G 140
ASP G 111
 None
 1.23A 1wg8A-4pkiG:
undetectable		 1wg8A-4pkiG:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 4pki GELSOLIN,TROPOMODULI
N-1 CHIMERA
(Homo
sapiens) 		3 / 3 VAL G  73
TRP G  71
VAL G  96
 None
 0.74A 2izqA-4pkiG:
undetectable
2izqB-4pkiG:
undetectable		 2izqA-4pkiG:
8.47
2izqB-4pkiG:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4pki GELSOLIN,TROPOMODULI
N-1 CHIMERA
(Homo
sapiens) 		4 / 5 LEU G  98
GLN G 109
THR G 100
THR G 132
 None
 1.06A 2zj0B-4pkiG:
undetectable		 2zj0B-4pkiG:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4pki GELSOLIN,TROPOMODULI
N-1 CHIMERA
(Homo
sapiens) 		4 / 5 LEU G  98
GLN G 109
THR G 100
THR G 132
 None
 1.03A 2zj0C-4pkiG:
undetectable		 2zj0C-4pkiG:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4pki GELSOLIN,TROPOMODULI
N-1 CHIMERA
(Homo
sapiens) 		4 / 4 LEU G  98
GLN G 109
THR G 100
THR G 132
 None
 1.06A 2zj0D-4pkiG:
undetectable		 2zj0D-4pkiG:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4pki GELSOLIN,TROPOMODULI
N-1 CHIMERA
(Homo
sapiens) 		4 / 5 LEU G  98
GLN G 109
THR G 100
THR G 132
 None
 1.05A 3ce6B-4pkiG:
undetectable		 3ce6B-4pkiG:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4pki GELSOLIN,TROPOMODULI
N-1 CHIMERA
(Homo
sapiens) 		5 / 12 ALA G1245
LEU G1276
ILE G1302
SER G1304
LEU G1306
 None
 1.16A 3k2hB-4pkiG:
2.2		 3k2hB-4pkiG:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 4pki GELSOLIN,TROPOMODULI
N-1 CHIMERA
(Homo
sapiens) 		3 / 3 VAL G  96
VAL G  73
TRP G  71
 None
 0.83A 3l8lA-4pkiG:
undetectable
3l8lB-4pkiG:
undetectable		 3l8lA-4pkiG:
8.47
3l8lB-4pkiG:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4pki GELSOLIN,TROPOMODULI
N-1 CHIMERA
(Homo
sapiens) 		3 / 3 GLY G 117
THR G  91
ASN G 118
 None
 0.70A 3v4tD-4pkiG:
1.3		 3v4tD-4pkiG:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4pki GELSOLIN,TROPOMODULI
N-1 CHIMERA
(Homo
sapiens) 		4 / 5 GLY G 175
ASP G 123
GLU G  74
VAL G  96
 None
 0.90A 4nkvD-4pkiG:
undetectable		 4nkvD-4pkiG:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4pki GELSOLIN,TROPOMODULI
N-1 CHIMERA
(Homo
sapiens) 		5 / 12 ILE G1231
LEU G1254
PHE G1229
THR G1186
ILE G1190
 None
 1.15A 4x5hA-4pkiG:
undetectable		 4x5hA-4pkiG:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4pki GELSOLIN,TROPOMODULI
N-1 CHIMERA
(Homo
sapiens) 		5 / 12 ILE G1231
LEU G1254
PHE G1229
THR G1186
ILE G1190
 None
 1.24A 5z6fA-4pkiG:
undetectable		 5z6fA-4pkiG:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 4pki GELSOLIN,TROPOMODULI
N-1 CHIMERA
(Homo
sapiens) 		4 / 7 ALA G1217
LYS G1221
GLU G1250
LEU G1254
 None
 0.88A 6ci6A-4pkiG:
undetectable		 6ci6A-4pkiG:
16.67