SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pkl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 4pkl BROMODOMAIN FACTOR 2
(Trypanosoma
brucei) 		4 / 7 PHE A  18
VAL A  19
ASN A  11
GLY A  14
 None
 1.12A 3kmoB-4pklA:
undetectable		 3kmoB-4pklA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 4pkl BROMODOMAIN FACTOR 2
(Trypanosoma
brucei) 		5 / 11 THR A 102
ALA A  76
ILE A  79
PHE A  99
THR A  67
 None
 1.33A 3qelA-4pklA:
undetectable
3qelB-4pklA:
undetectable		 3qelA-4pklA:
14.14
3qelB-4pklA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 4pkl BROMODOMAIN FACTOR 2
(Trypanosoma
brucei) 		4 / 7 TYR A  43
MET A  78
ALA A  82
ASN A  86
 None
None
None
1GH  A 201 ( 3.0A)
 0.38A 4y03A-4pklA:
13.7		 4y03A-4pklA:
29.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4pkl BROMODOMAIN FACTOR 2
(Trypanosoma
brucei) 		4 / 6 PHE A  31
SER A  98
LEU A  25
LEU A  22
 None
 1.36A 5dzke-4pklA:
undetectable
5dzks-4pklA:
undetectable		 5dzke-4pklA:
22.90
5dzks-4pklA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 4pkl BROMODOMAIN FACTOR 2
(Trypanosoma
brucei) 		5 / 12 THR A 102
ALA A  76
ILE A  79
PHE A  99
THR A  67
 None
 1.32A 5ewjC-4pklA:
undetectable
5ewjD-4pklA:
undetectable		 5ewjC-4pklA:
13.85
5ewjD-4pklA:
15.30