SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pkv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 9 PHE A 688
ILE A 666
GLY A 683
PHE A 684
TYR A 728
 None
None
30R  A 801 ( 4.2A)
None
30R  A 801 (-3.4A)
 1.49A 1i00B-4pkvA:
undetectable		 1i00B-4pkvA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 12 HIS A 686
GLU A 687
HIS A 690
GLU A 735
TYR A 728
 ZN  A 802 ( 3.6A)
30R  A 801 (-2.8A)
ZN  A 802 ( 3.4A)
ZN  A 802 ( 2.5A)
30R  A 801 (-3.4A)
 0.69A 1j36A-4pkvA:
undetectable		 1j36A-4pkvA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 12 HIS A 686
GLU A 687
HIS A 690
GLU A 735
TYR A 728
 ZN  A 802 ( 3.6A)
30R  A 801 (-2.8A)
ZN  A 802 ( 3.4A)
ZN  A 802 ( 2.5A)
30R  A 801 (-3.4A)
 0.70A 1j36B-4pkvA:
undetectable		 1j36B-4pkvA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 11 HIS A 686
GLU A 687
HIS A 690
GLU A 735
TYR A 728
 ZN  A 802 ( 3.6A)
30R  A 801 (-2.8A)
ZN  A 802 ( 3.4A)
ZN  A 802 ( 2.5A)
30R  A 801 (-3.4A)
 0.67A 1j37A-4pkvA:
5.1		 1j37A-4pkvA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 11 HIS A 686
GLU A 687
HIS A 690
GLU A 735
TYR A 728
 ZN  A 802 ( 3.6A)
30R  A 801 (-2.8A)
ZN  A 802 ( 3.4A)
ZN  A 802 ( 2.5A)
30R  A 801 (-3.4A)
 0.67A 1j37B-4pkvA:
undetectable		 1j37B-4pkvA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		4 / 7 SER A 746
ASP A 748
GLU A 682
GLU A 739
 None
None
None
30R  A 801 (-3.4A)
 1.17A 1knyA-4pkvA:
undetectable
1knyB-4pkvA:
undetectable		 1knyA-4pkvA:
19.09
1knyB-4pkvA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		4 / 8 GLU A 739
SER A 746
ASP A 748
GLU A 682
 30R  A 801 (-3.4A)
None
None
None
 1.17A 1knyA-4pkvA:
undetectable
1knyB-4pkvA:
undetectable		 1knyA-4pkvA:
19.09
1knyB-4pkvA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 12 HIS A 686
GLU A 687
HIS A 690
GLU A 735
TYR A 728
 ZN  A 802 ( 3.6A)
30R  A 801 (-2.8A)
ZN  A 802 ( 3.4A)
ZN  A 802 ( 2.5A)
30R  A 801 (-3.4A)
 0.64A 1o86A-4pkvA:
5.0		 1o86A-4pkvA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		3 / 3 ASP A 400
LYS A 410
ARG A 414
 None
 1.19A 1ra8A-4pkvA:
undetectable		 1ra8A-4pkvA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		3 / 3 SER A 480
VAL A 549
LEU A 527
 None
 0.69A 1yajG-4pkvA:
undetectable		 1yajG-4pkvA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 12 HIS A 686
GLU A 687
HIS A 690
GLU A 735
TYR A 728
 ZN  A 802 ( 3.6A)
30R  A 801 (-2.8A)
ZN  A 802 ( 3.4A)
ZN  A 802 ( 2.5A)
30R  A 801 (-3.4A)
 0.59A 2c6nA-4pkvA:
3.3		 2c6nA-4pkvA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 12 HIS A 686
GLU A 687
HIS A 690
GLU A 735
TYR A 728
 ZN  A 802 ( 3.6A)
30R  A 801 (-2.8A)
ZN  A 802 ( 3.4A)
ZN  A 802 ( 2.5A)
30R  A 801 (-3.4A)
 0.63A 2c6nB-4pkvA:
undetectable		 2c6nB-4pkvA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 10 PHE A 688
ILE A 666
GLY A 683
PHE A 684
TYR A 728
 None
None
30R  A 801 ( 4.2A)
None
30R  A 801 (-3.4A)
 1.36A 2tsrC-4pkvA:
undetectable		 2tsrC-4pkvA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 9 PHE A 688
ILE A 666
GLY A 683
PHE A 684
TYR A 728
 None
None
30R  A 801 ( 4.2A)
None
30R  A 801 (-3.4A)
 1.43A 2tsrD-4pkvA:
undetectable		 2tsrD-4pkvA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 11 LEU A 514
LEU A 437
VAL A 486
LEU A 293
ILE A 427
 None
 1.18A 2uxoB-4pkvA:
undetectable		 2uxoB-4pkvA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 11 HIS A 686
GLU A 687
HIS A 690
GLU A 735
TYR A 728
 ZN  A 802 ( 3.6A)
30R  A 801 (-2.8A)
ZN  A 802 ( 3.4A)
ZN  A 802 ( 2.5A)
30R  A 801 (-3.4A)
 0.63A 2x8zA-4pkvA:
4.9		 2x8zA-4pkvA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 12 HIS A 686
GLU A 687
HIS A 690
GLU A 735
TYR A 728
 ZN  A 802 ( 3.6A)
30R  A 801 (-2.8A)
ZN  A 802 ( 3.4A)
ZN  A 802 ( 2.5A)
30R  A 801 (-3.4A)
 0.63A 2x91A-4pkvA:
undetectable		 2x91A-4pkvA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		4 / 7 SER A 598
ILE A 602
PRO A 671
GLY A 670
 None
 0.92A 2y7kA-4pkvA:
undetectable		 2y7kA-4pkvA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		4 / 4 ILE A 463
ARG A 502
ILE A 543
THR A 461
 None
 1.23A 3ia4C-4pkvA:
undetectable		 3ia4C-4pkvA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 12 GLY A 397
ASP A 420
ILE A 416
ASP A 394
LEU A 392
 None
 1.10A 3iv6D-4pkvA:
undetectable		 3iv6D-4pkvA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		3 / 3 LYS A 656
ILE A 467
PHE A 468
 None
 1.00A 3j7zS-4pkvA:
undetectable
3j7za-4pkvA:
undetectable		 3j7zS-4pkvA:
10.79
3j7za-4pkvA:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		4 / 5 LEU A 574
ARG A 628
ILE A 666
PHE A 629
 None
 1.26A 3ln1D-4pkvA:
undetectable		 3ln1D-4pkvA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		3 / 3 PHE A 688
TYR A 695
LEU A 658
 None
 0.75A 3sueB-4pkvA:
undetectable		 3sueB-4pkvA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		4 / 6 LEU A 431
ALA A 511
THR A 509
LEU A 437
 None
 0.98A 3t3zA-4pkvA:
undetectable		 3t3zA-4pkvA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		4 / 6 LEU A 431
ALA A 511
THR A 509
LEU A 437
 None
 1.01A 3t3zD-4pkvA:
undetectable		 3t3zD-4pkvA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		4 / 5 ILE A 525
SER A 553
LYS A 552
GLY A 526
 None
 0.91A 3tkdB-4pkvA:
undetectable		 3tkdB-4pkvA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		4 / 5 ILE A 525
SER A 553
LYS A 552
GLY A 526
 None
 0.89A 3tkdA-4pkvA:
undetectable		 3tkdA-4pkvA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 11 HIS A 686
GLU A 687
HIS A 690
GLU A 735
TYR A 728
 ZN  A 802 ( 3.6A)
30R  A 801 (-2.8A)
ZN  A 802 ( 3.4A)
ZN  A 802 ( 2.5A)
30R  A 801 (-3.4A)
 0.67A 4c2pA-4pkvA:
4.7		 4c2pA-4pkvA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR5_A_SRYA1860_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		3 / 3 LYS A 304
PRO A 302
LYS A 340
 None
 1.13A 4dr5L-4pkvA:
undetectable		 4dr5L-4pkvA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR6_A_SRYA1956_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		3 / 3 LYS A 304
PRO A 302
LYS A 340
 None
 1.06A 4dr6L-4pkvA:
undetectable		 4dr6L-4pkvA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUZ_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		3 / 3 LYS A 304
PRO A 302
LYS A 340
 None
 1.33A 4duzL-4pkvA:
undetectable		 4duzL-4pkvA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 10 PHE A 688
ILE A 666
GLY A 683
PHE A 684
TYR A 728
 None
None
30R  A 801 ( 4.2A)
None
30R  A 801 (-3.4A)
 1.43A 4eb4D-4pkvA:
undetectable		 4eb4D-4pkvA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 12 HIS A 686
GLU A 687
HIS A 690
GLU A 735
TYR A 728
 ZN  A 802 ( 3.6A)
30R  A 801 (-2.8A)
ZN  A 802 ( 3.4A)
ZN  A 802 ( 2.5A)
30R  A 801 (-3.4A)
 0.40A 4r7lA-4pkvA:
2.8		 4r7lA-4pkvA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		4 / 4 HIS A 690
HIS A 686
TYR A 728
GLU A 735
 ZN  A 802 ( 3.4A)
ZN  A 802 ( 3.6A)
30R  A 801 (-3.4A)
ZN  A 802 ( 2.5A)
 1.41A 5pahA-4pkvA:
undetectable		 5pahA-4pkvA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4pkv LETHAL FACTOR
(Bacillus
anthracis) 		5 / 10 PHE A 688
ILE A 666
GLY A 683
PHE A 684
TYR A 728
 None
None
30R  A 801 ( 4.2A)
None
30R  A 801 (-3.4A)
 1.44A 5x66D-4pkvA:
undetectable		 5x66D-4pkvA:
18.86