SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pl0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD
(Escherichia
coli) 		4 / 7 LEU A 387
LEU A 361
SER A 353
SER A 351
 None
 1.00A 1dvxA-4pl0A:
undetectable		 1dvxA-4pl0A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD
(Escherichia
coli) 		5 / 12 TYR A 137
LEU A  16
LEU A 317
TYR A  12
ILE A  13
 None
 1.39A 1fmlA-4pl0A:
undetectable		 1fmlA-4pl0A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD
(Escherichia
coli) 		4 / 8 ARG A 141
ASN A 142
ASN A 134
ASP A 135
 None
 1.33A 1rs6A-4pl0A:
undetectable		 1rs6A-4pl0A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD
(Escherichia
coli) 		5 / 12 ILE A 391
ILE A 402
ARG A 410
LEU A 368
LEU A 551
 None
 1.00A 1xdkF-4pl0A:
undetectable		 1xdkF-4pl0A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD
(Escherichia
coli) 		4 / 8 ARG A 141
ASN A 142
ASN A 134
ASP A 135
 None
 1.34A 1zzqA-4pl0A:
undetectable		 1zzqA-4pl0A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD
(Escherichia
coli) 		4 / 8 ARG A 141
ASN A 142
ASN A 134
ASP A 135
 None
 1.33A 1zzqB-4pl0A:
undetectable		 1zzqB-4pl0A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD
(Escherichia
coli) 		5 / 9 TYR A 271
VAL A 172
GLY A 171
VAL A 161
ILE A 289
 None
 1.33A 2a1oB-4pl0A:
undetectable		 2a1oB-4pl0A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD
(Escherichia
coli) 		4 / 7 ILE A 523
LEU A 520
ARG A 493
THR A 425
 None
 1.13A 2zxwN-4pl0A:
1.4
2zxwW-4pl0A:
undetectable		 2zxwN-4pl0A:
21.25
2zxwW-4pl0A:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD
(Escherichia
coli) 		4 / 7 ILE A 523
LEU A 520
ARG A 493
THR A 425
 None
 0.98A 3ag2N-4pl0A:
3.3
3ag2W-4pl0A:
undetectable		 3ag2N-4pl0A:
21.25
3ag2W-4pl0A:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD
(Escherichia
coli) 		4 / 6 LEU A 361
SER A 351
PHE A 352
ILE A 390
 None
 0.78A 3ko0B-4pl0A:
undetectable		 3ko0B-4pl0A:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_A_ACTA601_0
(CHOLINE OXIDASE)		 4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD
(Escherichia
coli) 		4 / 5 ILE A 289
HIS A 285
VAL A 281
ASN A 272
 None
 1.31A 3nneA-4pl0A:
undetectable		 3nneA-4pl0A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD
(Escherichia
coli) 		5 / 12 GLY A 484
TYR A 481
ALA A 492
ASN A 515
LEU A 455
 None
 1.27A 3tm4A-4pl0A:
2.1		 3tm4A-4pl0A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD
(Escherichia
coli) 		5 / 12 GLY A 484
TYR A 481
ALA A 492
ASN A 515
LEU A 455
 None
 1.28A 3tm4B-4pl0A:
2.1		 3tm4B-4pl0A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD
(Escherichia
coli) 		4 / 5 VAL A 172
GLY A 171
TYR A 271
ASP A 166
 None
 1.25A 3w9tB-4pl0A:
undetectable		 3w9tB-4pl0A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD
(Escherichia
coli) 		4 / 5 VAL A 172
GLY A 171
TYR A 271
ASP A 166
 None
 1.26A 3w9tC-4pl0A:
undetectable		 3w9tC-4pl0A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD
(Escherichia
coli) 		4 / 5 VAL A 172
GLY A 171
TYR A 271
ASP A 166
 None
 1.26A 3w9tD-4pl0A:
undetectable		 3w9tD-4pl0A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD
(Escherichia
coli) 		4 / 5 VAL A 172
GLY A 171
TYR A 271
ASP A 166
 None
 1.25A 3w9tG-4pl0A:
undetectable		 3w9tG-4pl0A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD
(Escherichia
coli) 		4 / 6 ILE A 523
LEU A 520
ARG A 493
THR A 425
 None
 1.06A 3wg7A-4pl0A:
4.1
3wg7J-4pl0A:
undetectable		 3wg7A-4pl0A:
21.25
3wg7J-4pl0A:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD
(Escherichia
coli) 		3 / 3 TYR A 403
ARG A 410
SER A 408
 None
 1.03A 4khpI-4pl0A:
undetectable
4khpJ-4pl0A:
undetectable		 4khpI-4pl0A:
13.43
4khpJ-4pl0A:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD
(Escherichia
coli) 		4 / 8 SER A 207
LEU A 208
ASP A 211
ARG A 231
 None
 1.02A 4umjA-4pl0A:
undetectable		 4umjA-4pl0A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD
(Escherichia
coli) 		4 / 6 ILE A 523
LEU A 520
ARG A 493
THR A 425
 None
 0.93A 5b1aN-4pl0A:
4.1
5b1aW-4pl0A:
undetectable		 5b1aN-4pl0A:
21.25
5b1aW-4pl0A:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD
(Escherichia
coli) 		4 / 7 ILE A 321
PHE A 320
MET A 101
LEU A  16
 None
 0.84A 5b1bN-4pl0A:
3.4
5b1bW-4pl0A:
undetectable		 5b1bN-4pl0A:
21.25
5b1bW-4pl0A:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD
(Escherichia
coli) 		4 / 7 ILE A 321
PHE A 320
MET A 101
LEU A  16
 None
 0.86A 5b3sN-4pl0A:
2.8
5b3sW-4pl0A:
undetectable		 5b3sN-4pl0A:
21.25
5b3sW-4pl0A:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8O_B_CHDB1001_0
(GASTROTROPIN)		 4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD
(Escherichia
coli) 		5 / 12 TYR A 137
LEU A 191
SER A 308
GLU A 309
SER A 313
 None
 1.35A 5l8oB-4pl0A:
undetectable		 5l8oB-4pl0A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA609_0
(ACETYLCHOLINESTERASE)		 4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD
(Escherichia
coli) 		4 / 6 TYR A 394
TYR A 423
ASP A 414
TYR A 429
 None
 1.38A 5ov9A-4pl0A:
2.1		 5ov9A-4pl0A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD
(Escherichia
coli) 		4 / 7 TYR A 394
TYR A 423
ASP A 414
TYR A 429
 None
 1.37A 5ov9B-4pl0A:
2.1		 5ov9B-4pl0A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD
(Escherichia
coli) 		4 / 8 ARG A 141
ASN A 142
ASN A 134
ASP A 135
 None
 1.32A 5vunA-4pl0A:
undetectable		 5vunA-4pl0A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD
(Escherichia
coli) 		4 / 8 ARG A 141
ASN A 142
ASN A 134
ASP A 135
 None
 1.35A 5vunB-4pl0A:
undetectable		 5vunB-4pl0A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD
(Escherichia
coli) 		4 / 8 ARG A 141
ASN A 142
ASN A 134
ASP A 135
 None
 1.35A 5vuoB-4pl0A:
undetectable		 5vuoB-4pl0A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD
(Escherichia
coli) 		3 / 3 LYS A 453
ASN A 449
SER A 447
 None
 0.94A 5yw0A-4pl0A:
undetectable		 5yw0A-4pl0A:
19.02