SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pl2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L7F_A_BCZA801_1 (NEURAMINIDASE)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	3 / 3	ARG B 141 ARG B 103 ARG B 144	None	0.66A	1l7fA-4pl2B: undetectable	1l7fA-4pl2B: 21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L7H_A_BCZA801_1 (NEURAMINIDASE)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	3 / 3	ARG B 141 ARG B 103 ARG B 144	None	0.65A	1l7hA-4pl2B: undetectable	1l7hA-4pl2B: 21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1W76_A_GNTA1538_1 (ACETYLCHOLINESTERASE)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	5 / 11	GLY B 177 GLU B 278 SER B 233 PHE B 131 HIS B 235	SF4 B 401 (-3.6A) None SF4 B 401 ( 4.8A) SF4 B 401 ( 4.6A) None	1.39A	1w76A-4pl2B: 2.2	1w76A-4pl2B: 20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FB2_A_SAMA501_0 (MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN A)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	4 / 8	CYH B 132 GLU B 180 SER B 233 VAL B 280	SF4 B 401 (-2.1A) SF4 B 401 ( 4.8A) SF4 B 401 ( 4.8A) None	0.77A	2fb2A-4pl2B: 12.0	2fb2A-4pl2B: 23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FT9_A_CHDA130_0 (FATTY ACID-BINDING PROTEIN 2, LIVER)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	5 / 12	VAL B 333 ILE B 277 ILE B 306 CYH B 304 PHE B 339	None	1.16A	2ft9A-4pl2B: undetectable	2ft9A-4pl2B: 15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2G78_A_REAA200_1 (CELLULAR RETINOIC ACID-BINDING PROTEIN 2)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	6 / 12	PHE B 57 LEU B 71 ILE B 18 ALA B 75 VAL B 45 MET B 60	None	1.22A	2g78A-4pl2B: undetectable	2g78A-4pl2B: 17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HMA_A_SAMA375_0 (PROBABLE TRNA (5-METHYLAMINOMETHYL -2-THIOURIDYLATE)-ME THYLTRANSFERASE)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	5 / 11	GLY B 348 SER B 89 ASP B 112 THR B 92 GLY B 91	None	1.33A	2hmaA-4pl2B: undetectable	2hmaA-4pl2B: 21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2J9D_A_ACTA1117_0 (HYPOTHETICAL NITROGEN REGULATORY PII-LIKE PROTEIN MJ0059)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	3 / 3	ASP B 364 ARG B 365 ARG B 368	None	0.99A	2j9dA-4pl2B: undetectable 2j9dC-4pl2B: undetectable	2j9dA-4pl2B: 17.89 2j9dC-4pl2B: 17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YVL_D_SAMD603_0 (HYPOTHETICAL PROTEIN)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	5 / 12	GLY B 179 GLY B 177 ALA B 118 ALA B 135 PHE B 139	SF4 B 401 (-3.8A) SF4 B 401 (-3.6A) None SF4 B 401 (-3.5A) None	1.17A	2yvlD-4pl2B: undetectable	2yvlD-4pl2B: 22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B2R_A_VDNA1_1 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	5 / 12	ILE B 170 ALA B 191 ILE B 149 VAL B 119 ILE B 97	None	1.10A	3b2rA-4pl2B: undetectable	3b2rA-4pl2B: 20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B2R_B_VDNB1_1 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	5 / 11	ILE B 170 ALA B 191 ILE B 149 VAL B 119 ILE B 97	None	1.09A	3b2rB-4pl2B: undetectable	3b2rB-4pl2B: 20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KO0_B_TFPB202_1 (PROTEIN S100-A4)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	3 / 3	GLU B 193 LEU B 196 ASP B 197	None	0.46A	3ko0A-4pl2B: undetectable	3ko0A-4pl2B: 13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KO0_S_TFPS202_2 (PROTEIN S100-A4)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	3 / 3	GLU B 193 LEU B 196 ASP B 197	None	0.34A	3ko0T-4pl2B: undetectable	3ko0T-4pl2B: 13.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3RFA_A_SAMA406_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE N)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	8 / 12	PHE B 131 CYH B 132 GLU B 180 PRO B 181 HIS B 235 VAL B 280 ILE B 309 TRP B 311	SF4 B 401 ( 4.6A) SF4 B 401 (-2.1A) SF4 B 401 ( 4.8A) None None None None None	0.59A	3rfaA-4pl2B: 52.4	3rfaA-4pl2B: 99.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3RFA_A_SAMA406_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE N)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	7 / 12	PHE B 131 CYH B 132 HIS B 235 GLU B 278 VAL B 280 ILE B 309 TRP B 311	SF4 B 401 ( 4.6A) SF4 B 401 (-2.1A) None None None None None	0.89A	3rfaA-4pl2B: 52.4	3rfaA-4pl2B: 99.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3RFA_A_SAMA406_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE N)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	8 / 12	PHE B 131 CYH B 132 MET B 176 GLU B 180 PRO B 181 HIS B 235 VAL B 280 ILE B 309	SF4 B 401 ( 4.6A) SF4 B 401 (-2.1A) None SF4 B 401 ( 4.8A) None None None None	0.75A	3rfaA-4pl2B: 52.4	3rfaA-4pl2B: 99.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3RFA_A_SAMA406_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE N)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	7 / 12	PHE B 131 CYH B 132 MET B 176 GLU B 180 PRO B 181 SER B 213 ILE B 309	SF4 B 401 ( 4.6A) SF4 B 401 (-2.1A) None SF4 B 401 ( 4.8A) None SF4 B 401 (-3.1A) None	0.91A	3rfaA-4pl2B: 52.4	3rfaA-4pl2B: 99.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3RFA_A_SAMA406_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE N)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	7 / 12	PHE B 131 CYH B 132 MET B 176 HIS B 235 GLU B 278 VAL B 280 ILE B 309	SF4 B 401 ( 4.6A) SF4 B 401 (-2.1A) None None None None None	1.04A	3rfaA-4pl2B: 52.4	3rfaA-4pl2B: 99.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3RFA_B_SAMB406_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE N)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	8 / 12	PHE B 131 CYH B 132 GLU B 180 PRO B 181 SER B 211 HIS B 235 VAL B 280 TRP B 311	SF4 B 401 ( 4.6A) SF4 B 401 (-2.1A) SF4 B 401 ( 4.8A) None None None None None	0.56A	3rfaB-4pl2B: 54.1	3rfaB-4pl2B: 99.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3RFA_B_SAMB406_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE N)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	7 / 12	PHE B 131 CYH B 132 MET B 176 GLU B 180 PRO B 181 SER B 211 SER B 213	SF4 B 401 ( 4.6A) SF4 B 401 (-2.1A) None SF4 B 401 ( 4.8A) None None SF4 B 401 (-3.1A)	0.92A	3rfaB-4pl2B: 54.1	3rfaB-4pl2B: 99.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3RFA_B_SAMB406_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE N)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	9 / 12	PHE B 131 CYH B 132 MET B 176 GLU B 180 PRO B 181 SER B 211 SER B 233 HIS B 235 VAL B 280	SF4 B 401 ( 4.6A) SF4 B 401 (-2.1A) None SF4 B 401 ( 4.8A) None None SF4 B 401 ( 4.8A) None None	0.76A	3rfaB-4pl2B: 54.1	3rfaB-4pl2B: 99.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3U6T_A_KANA4699_1 (RIBOSOME INACTIVATING PROTEIN)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	5 / 10	ILE B 77 GLU B 59 ALA B 79 GLU B 81 ARG B 154	None	1.16A	3u6tA-4pl2B: undetectable	3u6tA-4pl2B: 22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UFG_B_LEUB289_0 (GLYCYL-TRNA SYNTHETASE ALPHA SUBUNIT)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	3 / 3	PHE B 131 SER B 213 SER B 233	SF4 B 401 ( 4.6A) SF4 B 401 (-3.1A) SF4 B 401 ( 4.8A)	0.96A	3ufgB-4pl2B: undetectable	3ufgB-4pl2B: 20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K37_A_SAMA504_0 (ANAEROBIC SULFATASE-MATURATING ENZYME)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	5 / 11	CYH B 132 GLU B 180 SER B 233 VAL B 280 ILE B 309	SF4 B 401 (-2.1A) SF4 B 401 ( 4.8A) SF4 B 401 ( 4.8A) None None	0.65A	4k37A-4pl2B: 4.5	4k37A-4pl2B: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LJ0_A_ACTA505_0 (NAB2)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	3 / 3	LEU B 370 LYS B 367 THR B 366	None	0.59A	4lj0A-4pl2B: undetectable	4lj0A-4pl2B: 11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NKV_B_AERB601_2 (STEROID 17-ALPHA-HYDROXYLASE /17,20 LYASE)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	4 / 5	ARG B 25 ASP B 198 GLU B 193 VAL B 228	None	1.33A	4nkvB-4pl2B: undetectable	4nkvB-4pl2B: 22.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4PL1_A_SAMA401_0 (DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	7 / 11	PHE B 131 GLU B 180 PRO B 181 SER B 211 HIS B 235 ILE B 309 TRP B 311	SF4 B 401 ( 4.6A) SF4 B 401 ( 4.8A) None None None None None	0.64A	4pl1A-4pl2B: 50.8	4pl1A-4pl2B: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4PL1_A_SAMA401_0 (DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	7 / 11	PHE B 131 GLU B 180 PRO B 181 SER B 211 SER B 233 HIS B 235 ILE B 309	SF4 B 401 ( 4.6A) SF4 B 401 ( 4.8A) None None SF4 B 401 ( 4.8A) None None	0.48A	4pl1A-4pl2B: 50.8	4pl1A-4pl2B: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4PL1_A_SAMA401_0 (DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	5 / 11	PHE B 131 HIS B 235 GLU B 278 ILE B 309 TRP B 311	SF4 B 401 ( 4.6A) None None None None	0.99A	4pl1A-4pl2B: 50.8	4pl1A-4pl2B: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4PL1_A_SAMA401_0 (DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	7 / 11	PHE B 131 MET B 176 GLU B 180 PRO B 181 SER B 211 SER B 233 ILE B 309	SF4 B 401 ( 4.6A) None SF4 B 401 ( 4.8A) None None SF4 B 401 ( 4.8A) None	0.72A	4pl1A-4pl2B: 50.8	4pl1A-4pl2B: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4PL1_A_SAMA401_0 (DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	5 / 11	PHE B 131 MET B 176 SER B 233 GLU B 278 ILE B 309	SF4 B 401 ( 4.6A) None SF4 B 401 ( 4.8A) None None	1.16A	4pl1A-4pl2B: 50.8	4pl1A-4pl2B: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4PL1_A_SAMA401_0 (DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	5 / 11	PHE B 131 SER B 233 HIS B 235 GLU B 278 ILE B 309	SF4 B 401 ( 4.6A) SF4 B 401 ( 4.8A) None None None	0.91A	4pl1A-4pl2B: 50.8	4pl1A-4pl2B: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4PL1_B_SAMB401_0 (DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	6 / 10	CYH B 132 GLU B 180 PRO B 181 SER B 211 HIS B 235 TRP B 311	SF4 B 401 (-2.1A) SF4 B 401 ( 4.8A) None None None None	0.59A	4pl1B-4pl2B: 52.7	4pl1B-4pl2B: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4PL1_B_SAMB401_0 (DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	6 / 10	CYH B 132 GLU B 180 PRO B 181 SER B 211 SER B 233 HIS B 235	SF4 B 401 (-2.1A) SF4 B 401 ( 4.8A) None None SF4 B 401 ( 4.8A) None	0.52A	4pl1B-4pl2B: 52.7	4pl1B-4pl2B: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4PL1_B_SAMB401_0 (DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	6 / 10	CYH B 132 MET B 176 GLU B 180 PRO B 181 SER B 211 SER B 233	SF4 B 401 (-2.1A) None SF4 B 401 ( 4.8A) None None SF4 B 401 ( 4.8A)	0.70A	4pl1B-4pl2B: 52.7	4pl1B-4pl2B: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RP8_C_ASCC501_0 (ASCORBATE-SPECIFIC PERMEASE IIC COMPONENT ULAA)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	5 / 12	LEU B 298 ILE B 306 ILE B 254 ALA B 236 ILE B 232	None	1.14A	4rp8C-4pl2B: undetectable	4rp8C-4pl2B: 19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L6E_B_ACTB401_0 (N6-ADENOSINE-METHYLT RANSFERASE 70 KDA SUBUNIT N6-ADENOSINE-METHYLT RANSFERASE SUBUNIT METTL14)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	4 / 6	GLU B 111 ARG B 347 ARG B 344 ARG B 114	None	1.20A	5l6eA-4pl2B: undetectable 5l6eB-4pl2B: undetectable	5l6eA-4pl2B: 21.67 5l6eB-4pl2B: 20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MUG_A_VIVA301_1 (ALPHA-TOCOPHEROL TRANSFER PROTEIN)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	3 / 3	SER B 233 SER B 211 PHE B 131	SF4 B 401 ( 4.8A) None SF4 B 401 ( 4.6A)	0.92A	5mugA-4pl2B: 3.7	5mugA-4pl2B: 20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OM3_B_DXTB501_1 (ALPHA-1-ANTICHYMOTRY PSIN)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	4 / 6	LEU B 308 SER B 331 PHE B 330 HIS B 293	None	1.08A	5om3A-4pl2B: undetectable 5om3B-4pl2B: undetectable	5om3A-4pl2B: 15.25 5om3B-4pl2B: 8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6E43_A_BEZA502_0 (INDOLEAMINE 2,3-DIOXYGENASE 1)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	4 / 6	PHE B 330 LEU B 298 LEU B 295 HIS B 291	None	0.81A	6e43A-4pl2B: undetectable	6e43A-4pl2B: 22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6E43_B_BEZB502_0 (INDOLEAMINE 2,3-DIOXYGENASE 1)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	4 / 6	PHE B 330 LEU B 298 LEU B 295 HIS B 291	None	0.88A	6e43B-4pl2B: undetectable	6e43B-4pl2B: 22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6E43_C_BEZC502_0 (INDOLEAMINE 2,3-DIOXYGENASE 1)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	4 / 6	PHE B 330 LEU B 298 LEU B 295 HIS B 291	None	0.79A	6e43C-4pl2B: undetectable	6e43C-4pl2B: 22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6E43_D_BEZD502_0 (INDOLEAMINE 2,3-DIOXYGENASE 1)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	4 / 6	PHE B 330 LEU B 298 LEU B 295 HIS B 291	None	0.89A	6e43D-4pl2B: undetectable	6e43D-4pl2B: 22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FDY_U_DB8U302_1 (-)	4pl2	DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN (Escherichia coli)	5 / 9	LEU B 265 VAL B 275 SER B 213 LEU B 234 ILE B 277	None None SF4 B 401 (-3.1A) None None	1.36A	6fdyU-4pl2B: undetectable	6fdyU-4pl2B: 18.94

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1L7F_A_BCZA801_1","NEURAMINIDASE","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",3,"ARG B 141;ARG B 103;ARG B 144","None","0.66A","1l7fA-4pl2B:undetectable","1l7fA-4pl2B:21.46"],["1L7H_A_BCZA801_1","NEURAMINIDASE","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",3,"ARG B 141;ARG B 103;ARG B 144","None","0.65A","1l7hA-4pl2B:undetectable","1l7hA-4pl2B:21.46"],["1W76_A_GNTA1538_1","ACETYLCHOLINESTERASE","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",5,"GLY B 177;GLU B 278;SER B 233;PHE B 131;HIS B 235","SF4 B 401 (-3.6A);None;SF4 B 401 ( 4.8A);SF4 B 401 ( 4.6A);None","1.39A","1w76A-4pl2B:2.2","1w76A-4pl2B:20.87"],["2FB2_A_SAMA501_0","MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN A","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",4,"CYH B 132;GLU B 180;SER B 233;VAL B 280","SF4 B 401 (-2.1A);SF4 B 401 ( 4.8A);SF4 B 401 ( 4.8A);None","0.77A","2fb2A-4pl2B:12.0","2fb2A-4pl2B:23.39"],["2FT9_A_CHDA130_0","FATTY ACID-BINDING PROTEIN 2, LIVER","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",5,"VAL B 333;ILE B 277;ILE B 306;CYH B 304;PHE B 339","None","1.16A","2ft9A-4pl2B:undetectable","2ft9A-4pl2B:15.58"],["2G78_A_REAA200_1","CELLULAR RETINOIC ACID-BINDING PROTEIN 2","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",6,"PHE B  57;LEU B  71;ILE B  18;ALA B  75;VAL B  45;MET B  60","None","1.22A","2g78A-4pl2B:undetectable","2g78A-4pl2B:17.70"],["2HMA_A_SAMA375_0","PROBABLE TRNA (5-METHYLAMINOMETHYL-2-THIOURIDYLATE)-METHYLTRANSFERASE","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",5,"GLY B 348;SER B  89;ASP B 112;THR B  92;GLY B  91","None","1.33A","2hmaA-4pl2B:undetectable","2hmaA-4pl2B:21.58"],["2J9D_A_ACTA1117_0","HYPOTHETICAL NITROGEN REGULATORY PII-LIKE PROTEIN MJ0059","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",3,"ASP B 364;ARG B 365;ARG B 368","None","0.99A","2j9dA-4pl2B:undetectable;2j9dC-4pl2B:undetectable","2j9dA-4pl2B:17.89;2j9dC-4pl2B:17.89"],["2YVL_D_SAMD603_0","HYPOTHETICAL PROTEIN","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",5,"GLY B 179;GLY B 177;ALA B 118;ALA B 135;PHE B 139","SF4 B 401 (-3.8A);SF4 B 401 (-3.6A);None;SF4 B 401 (-3.5A);None","1.17A","2yvlD-4pl2B:undetectable","2yvlD-4pl2B:22.83"],["3B2R_A_VDNA1_1","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",5,"ILE B 170;ALA B 191;ILE B 149;VAL B 119;ILE B  97","None","1.10A","3b2rA-4pl2B:undetectable","3b2rA-4pl2B:20.48"],["3B2R_B_VDNB1_1","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",5,"ILE B 170;ALA B 191;ILE B 149;VAL B 119;ILE B  97","None","1.09A","3b2rB-4pl2B:undetectable","3b2rB-4pl2B:20.48"],["3KO0_B_TFPB202_1","PROTEIN S100-A4;PROTEIN S100-A4","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",3,"GLU B 193;LEU B 196;ASP B 197","None","0.46A","3ko0A-4pl2B:undetectable","3ko0A-4pl2B:13.39"],["3KO0_S_TFPS202_2","PROTEIN S100-A4;PROTEIN S100-A4","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",3,"GLU B 193;LEU B 196;ASP B 197","None","0.34A","3ko0T-4pl2B:undetectable","3ko0T-4pl2B:13.39"],["3RFA_A_SAMA406_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE N","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",8,"PHE B 131;CYH B 132;GLU B 180;PRO B 181;HIS B 235;VAL B 280;ILE B 309;TRP B 311","SF4 B 401 ( 4.6A);SF4 B 401 (-2.1A);SF4 B 401 ( 4.8A);None;None;None;None;None","0.59A","3rfaA-4pl2B:52.4","3rfaA-4pl2B:99.72"],["3RFA_A_SAMA406_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE N","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",7,"PHE B 131;CYH B 132;HIS B 235;GLU B 278;VAL B 280;ILE B 309;TRP B 311","SF4 B 401 ( 4.6A);SF4 B 401 (-2.1A);None;None;None;None;None","0.89A","3rfaA-4pl2B:52.4","3rfaA-4pl2B:99.72"],["3RFA_A_SAMA406_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE N","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",8,"PHE B 131;CYH B 132;MET B 176;GLU B 180;PRO B 181;HIS B 235;VAL B 280;ILE B 309","SF4 B 401 ( 4.6A);SF4 B 401 (-2.1A);None;SF4 B 401 ( 4.8A);None;None;None;None","0.75A","3rfaA-4pl2B:52.4","3rfaA-4pl2B:99.72"],["3RFA_A_SAMA406_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE N","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",7,"PHE B 131;CYH B 132;MET B 176;GLU B 180;PRO B 181;SER B 213;ILE B 309","SF4 B 401 ( 4.6A);SF4 B 401 (-2.1A);None;SF4 B 401 ( 4.8A);None;SF4 B 401 (-3.1A);None","0.91A","3rfaA-4pl2B:52.4","3rfaA-4pl2B:99.72"],["3RFA_A_SAMA406_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE N","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",7,"PHE B 131;CYH B 132;MET B 176;HIS B 235;GLU B 278;VAL B 280;ILE B 309","SF4 B 401 ( 4.6A);SF4 B 401 (-2.1A);None;None;None;None;None","1.04A","3rfaA-4pl2B:52.4","3rfaA-4pl2B:99.72"],["3RFA_B_SAMB406_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE N","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",8,"PHE B 131;CYH B 132;GLU B 180;PRO B 181;SER B 211;HIS B 235;VAL B 280;TRP B 311","SF4 B 401 ( 4.6A);SF4 B 401 (-2.1A);SF4 B 401 ( 4.8A);None;None;None;None;None","0.56A","3rfaB-4pl2B:54.1","3rfaB-4pl2B:99.72"],["3RFA_B_SAMB406_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE N","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",7,"PHE B 131;CYH B 132;MET B 176;GLU B 180;PRO B 181;SER B 211;SER B 213","SF4 B 401 ( 4.6A);SF4 B 401 (-2.1A);None;SF4 B 401 ( 4.8A);None;None;SF4 B 401 (-3.1A)","0.92A","3rfaB-4pl2B:54.1","3rfaB-4pl2B:99.72"],["3RFA_B_SAMB406_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE N","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",9,"PHE B 131;CYH B 132;MET B 176;GLU B 180;PRO B 181;SER B 211;SER B 233;HIS B 235;VAL B 280","SF4 B 401 ( 4.6A);SF4 B 401 (-2.1A);None;SF4 B 401 ( 4.8A);None;None;SF4 B 401 ( 4.8A);None;None","0.76A","3rfaB-4pl2B:54.1","3rfaB-4pl2B:99.72"],["3U6T_A_KANA4699_1","RIBOSOME INACTIVATING PROTEIN","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",5,"ILE B  77;GLU B  59;ALA B  79;GLU B  81;ARG B 154","None","1.16A","3u6tA-4pl2B:undetectable","3u6tA-4pl2B:22.43"],["3UFG_B_LEUB289_0","GLYCYL-TRNA SYNTHETASE ALPHA SUBUNIT","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",3,"PHE B 131;SER B 213;SER B 233","SF4 B 401 ( 4.6A);SF4 B 401 (-3.1A);SF4 B 401 ( 4.8A)","0.96A","3ufgB-4pl2B:undetectable","3ufgB-4pl2B:20.32"],["4K37_A_SAMA504_0","ANAEROBIC SULFATASE-MATURATING ENZYME","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",5,"CYH B 132;GLU B 180;SER B 233;VAL B 280;ILE B 309","SF4 B 401 (-2.1A);SF4 B 401 ( 4.8A);SF4 B 401 ( 4.8A);None;None","0.65A","4k37A-4pl2B:4.5","4k37A-4pl2B:20.00"],["4LJ0_A_ACTA505_0","NAB2","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",3,"LEU B 370;LYS B 367;THR B 366","None","0.59A","4lj0A-4pl2B:undetectable","4lj0A-4pl2B:11.75"],["4NKV_B_AERB601_2","STEROID 17-ALPHA-HYDROXYLASE\/17,20 LYASE","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",4,"ARG B  25;ASP B 198;GLU B 193;VAL B 228","None","1.33A","4nkvB-4pl2B:undetectable","4nkvB-4pl2B:22.40"],["4PL1_A_SAMA401_0","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",7,"PHE B 131;GLU B 180;PRO B 181;SER B 211;HIS B 235;ILE B 309;TRP B 311","SF4 B 401 ( 4.6A);SF4 B 401 ( 4.8A);None;None;None;None;None","0.64A","4pl1A-4pl2B:50.8","4pl1A-4pl2B:100.00"],["4PL1_A_SAMA401_0","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",7,"PHE B 131;GLU B 180;PRO B 181;SER B 211;SER B 233;HIS B 235;ILE B 309","SF4 B 401 ( 4.6A);SF4 B 401 ( 4.8A);None;None;SF4 B 401 ( 4.8A);None;None","0.48A","4pl1A-4pl2B:50.8","4pl1A-4pl2B:100.00"],["4PL1_A_SAMA401_0","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",5,"PHE B 131;HIS B 235;GLU B 278;ILE B 309;TRP B 311","SF4 B 401 ( 4.6A);None;None;None;None","0.99A","4pl1A-4pl2B:50.8","4pl1A-4pl2B:100.00"],["4PL1_A_SAMA401_0","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",7,"PHE B 131;MET B 176;GLU B 180;PRO B 181;SER B 211;SER B 233;ILE B 309","SF4 B 401 ( 4.6A);None;SF4 B 401 ( 4.8A);None;None;SF4 B 401 ( 4.8A);None","0.72A","4pl1A-4pl2B:50.8","4pl1A-4pl2B:100.00"],["4PL1_A_SAMA401_0","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",5,"PHE B 131;MET B 176;SER B 233;GLU B 278;ILE B 309","SF4 B 401 ( 4.6A);None;SF4 B 401 ( 4.8A);None;None","1.16A","4pl1A-4pl2B:50.8","4pl1A-4pl2B:100.00"],["4PL1_A_SAMA401_0","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",5,"PHE B 131;SER B 233;HIS B 235;GLU B 278;ILE B 309","SF4 B 401 ( 4.6A);SF4 B 401 ( 4.8A);None;None;None","0.91A","4pl1A-4pl2B:50.8","4pl1A-4pl2B:100.00"],["4PL1_B_SAMB401_0","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",6,"CYH B 132;GLU B 180;PRO B 181;SER B 211;HIS B 235;TRP B 311","SF4 B 401 (-2.1A);SF4 B 401 ( 4.8A);None;None;None;None","0.59A","4pl1B-4pl2B:52.7","4pl1B-4pl2B:100.00"],["4PL1_B_SAMB401_0","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",6,"CYH B 132;GLU B 180;PRO B 181;SER B 211;SER B 233;HIS B 235","SF4 B 401 (-2.1A);SF4 B 401 ( 4.8A);None;None;SF4 B 401 ( 4.8A);None","0.52A","4pl1B-4pl2B:52.7","4pl1B-4pl2B:100.00"],["4PL1_B_SAMB401_0","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",6,"CYH B 132;MET B 176;GLU B 180;PRO B 181;SER B 211;SER B 233","SF4 B 401 (-2.1A);None;SF4 B 401 ( 4.8A);None;None;SF4 B 401 ( 4.8A)","0.70A","4pl1B-4pl2B:52.7","4pl1B-4pl2B:100.00"],["4RP8_C_ASCC501_0","ASCORBATE-SPECIFIC PERMEASE IIC COMPONENT ULAA","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",5,"LEU B 298;ILE B 306;ILE B 254;ALA B 236;ILE B 232","None","1.14A","4rp8C-4pl2B:undetectable","4rp8C-4pl2B:19.83"],["5L6E_B_ACTB401_0","N6-ADENOSINE-METHYLTRANSFERASE 70 KDA SUBUNIT;N6-ADENOSINE-METHYLTRANSFERASE SUBUNIT METTL14","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",4,"GLU B 111;ARG B 347;ARG B 344;ARG B 114","None","1.20A","5l6eA-4pl2B:undetectable;5l6eB-4pl2B:undetectable","5l6eA-4pl2B:21.67;5l6eB-4pl2B:20.43"],["5MUG_A_VIVA301_1","ALPHA-TOCOPHEROL TRANSFER PROTEIN","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",3,"SER B 233;SER B 211;PHE B 131","SF4 B 401 ( 4.8A);None;SF4 B 401 ( 4.6A)","0.92A","5mugA-4pl2B:3.7","5mugA-4pl2B:20.77"],["5OM3_B_DXTB501_1","ALPHA-1-ANTICHYMOTRYPSIN;ALPHA-1-ANTICHYMOTRYPSIN","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",4,"LEU B 308;SER B 331;PHE B 330;HIS B 293","None","1.08A","5om3A-4pl2B:undetectable;5om3B-4pl2B:undetectable","5om3A-4pl2B:15.25;5om3B-4pl2B:8.77"],["6E43_A_BEZA502_0","INDOLEAMINE 2,3-DIOXYGENASE 1","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",4,"PHE B 330;LEU B 298;LEU B 295;HIS B 291","None","0.81A","6e43A-4pl2B:undetectable","6e43A-4pl2B:22.47"],["6E43_B_BEZB502_0","INDOLEAMINE 2,3-DIOXYGENASE 1","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",4,"PHE B 330;LEU B 298;LEU B 295;HIS B 291","None","0.88A","6e43B-4pl2B:undetectable","6e43B-4pl2B:22.47"],["6E43_C_BEZC502_0","INDOLEAMINE 2,3-DIOXYGENASE 1","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",4,"PHE B 330;LEU B 298;LEU B 295;HIS B 291","None","0.79A","6e43C-4pl2B:undetectable","6e43C-4pl2B:22.47"],["6E43_D_BEZD502_0","INDOLEAMINE 2,3-DIOXYGENASE 1","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",4,"PHE B 330;LEU B 298;LEU B 295;HIS B 291","None","0.89A","6e43D-4pl2B:undetectable","6e43D-4pl2B:22.47"],["6FDY_U_DB8U302_1","-","4pl2","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","Escherichia coli",5,"LEU B 265;VAL B 275;SER B 213;LEU B 234;ILE B 277","None;None;SF4 B 401 (-3.1A);None;None","1.36A","6fdyU-4pl2B:undetectable","6fdyU-4pl2B:18.94"]]