SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pl7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 4pl7 ACTIN,THYMOSIN
BETA-4
(Homo
sapiens;
Komagataella
phaffii) 		3 / 3 GLU A 259
HIS A 263
ASP A 222
 None
 0.78A 1i9gA-4pl7A:
undetectable		 1i9gA-4pl7A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 4pl7 ACTIN,THYMOSIN
BETA-4
(Homo
sapiens;
Komagataella
phaffii) 		4 / 5 THR A 409
ASP A  25
PRO A  27
SER A 344
 None
 1.21A 2hdnA-4pl7A:
undetectable
2hdnB-4pl7A:
1.9
2hdnD-4pl7A:
2.3		 2hdnA-4pl7A:
7.18
2hdnB-4pl7A:
21.51
2hdnD-4pl7A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 4pl7 ACTIN,THYMOSIN
BETA-4
(Homo
sapiens;
Komagataella
phaffii) 		4 / 5 SER A 344
THR A 409
ASP A  25
PRO A  27
 None
 1.24A 2hdnB-4pl7A:
1.9
2hdnC-4pl7A:
undetectable
2hdnD-4pl7A:
2.4		 2hdnB-4pl7A:
21.51
2hdnC-4pl7A:
7.18
2hdnD-4pl7A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 4pl7 ACTIN,THYMOSIN
BETA-4
(Homo
sapiens;
Komagataella
phaffii) 		4 / 7 THR A 409
PRO A  27
SER A 344
LEU A  96
 None
 1.06A 2hdnE-4pl7A:
undetectable
2hdnF-4pl7A:
2.9
2hdnH-4pl7A:
2.7		 2hdnE-4pl7A:
7.18
2hdnF-4pl7A:
21.51
2hdnH-4pl7A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 4pl7 ACTIN,THYMOSIN
BETA-4
(Homo
sapiens;
Komagataella
phaffii) 		4 / 6 SER A 344
THR A 409
ASP A  25
PRO A  27
 None
 1.22A 2hdnJ-4pl7A:
3.6
2hdnK-4pl7A:
undetectable
2hdnL-4pl7A:
2.4		 2hdnJ-4pl7A:
21.51
2hdnK-4pl7A:
7.18
2hdnL-4pl7A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4pl7 ACTIN,THYMOSIN
BETA-4
(Homo
sapiens;
Komagataella
phaffii) 		4 / 5 LEU A 180
VAL A 139
LEU A 140
ARG A 116
 None
 1.07A 2oiqA-4pl7A:
undetectable		 2oiqA-4pl7A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4pl7 ACTIN,THYMOSIN
BETA-4
(Homo
sapiens;
Komagataella
phaffii) 		3 / 3 PRO A 243
ASP A 244
GLU A 205
 None
 0.67A 3v4tC-4pl7A:
undetectable		 3v4tC-4pl7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4pl7 ACTIN,THYMOSIN
BETA-4
(Homo
sapiens;
Komagataella
phaffii) 		4 / 7 MET A 123
ILE A  10
VAL A  76
TRP A  79
 None
 1.20A 4f4dA-4pl7A:
undetectable		 4f4dA-4pl7A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4pl7 ACTIN,THYMOSIN
BETA-4
(Homo
sapiens;
Komagataella
phaffii) 		4 / 8 MET A 123
ILE A  10
VAL A  76
TRP A  79
 None
 1.23A 4f4dB-4pl7A:
2.1		 4f4dB-4pl7A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 4pl7 ACTIN,THYMOSIN
BETA-4
(Homo
sapiens;
Komagataella
phaffii) 		4 / 7 ALA A 260
PRO A 258
LEU A 180
LEU A 267
 None
 0.90A 4iomA-4pl7A:
undetectable		 4iomA-4pl7A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 4pl7 ACTIN,THYMOSIN
BETA-4
(Homo
sapiens;
Komagataella
phaffii) 		5 / 10 ASP A 154
ALA A 138
GLY A 342
ILE A 341
VAL A 152
 CA  A 502 ( 4.5A)
None
None
None
None
 1.05A 4j5jB-4pl7A:
undetectable		 4j5jB-4pl7A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4pl7 ACTIN,THYMOSIN
BETA-4
(Homo
sapiens;
Komagataella
phaffii) 		4 / 8 MET A 305
GLU A 214
GLU A 413
ARG A 210
 None
ATP  A 501 (-3.7A)
None
None
 1.08A 4mj8B-4pl7A:
undetectable
4mj8C-4pl7A:
undetectable		 4mj8B-4pl7A:
17.66
4mj8C-4pl7A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 4pl7 ACTIN,THYMOSIN
BETA-4
(Homo
sapiens;
Komagataella
phaffii) 		5 / 12 ALA A 181
GLY A 302
MET A  16
GLY A  15
TYR A  69
 None
ATP  A 501 (-3.4A)
None
ATP  A 501 (-3.7A)
None
 1.29A 4r29A-4pl7A:
undetectable		 4r29A-4pl7A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 4pl7 ACTIN,THYMOSIN
BETA-4
(Homo
sapiens;
Komagataella
phaffii) 		5 / 12 ALA A 181
GLY A 302
MET A  16
GLY A  15
TYR A  69
 None
ATP  A 501 (-3.4A)
None
ATP  A 501 (-3.7A)
None
 1.27A 4r29B-4pl7A:
undetectable		 4r29B-4pl7A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4pl7 ACTIN,THYMOSIN
BETA-4
(Homo
sapiens;
Komagataella
phaffii) 		3 / 3 GLU A 259
HIS A 263
ASP A 222
 None
 0.87A 5c0oG-4pl7A:
undetectable		 5c0oG-4pl7A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4pl7 ACTIN,THYMOSIN
BETA-4
(Homo
sapiens;
Komagataella
phaffii) 		3 / 3 GLN A 137
THR A 106
ASP A  11
 CA  A 502 ( 4.4A)
None
CA  A 502 ( 4.8A)
 0.91A 5k9dA-4pl7A:
undetectable		 5k9dA-4pl7A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4pl7 ACTIN,THYMOSIN
BETA-4
(Homo
sapiens;
Komagataella
phaffii) 		5 / 10 PHE A 306
SER A 155
GLY A 302
PHE A 262
ILE A 274
 ATP  A 501 (-3.6A)
None
ATP  A 501 (-3.4A)
None
None
 1.14A 6ebpB-4pl7A:
undetectable		 6ebpB-4pl7A:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4pl7 ACTIN,THYMOSIN
BETA-4
(Homo
sapiens;
Komagataella
phaffii) 		5 / 10 PHE A 306
SER A 155
GLY A 302
PHE A 262
ILE A 274
 ATP  A 501 (-3.6A)
None
ATP  A 501 (-3.4A)
None
None
 1.17A 6ebpC-4pl7A:
undetectable		 6ebpC-4pl7A:
10.98