SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4pl9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 4pl9 ETHYLENE RECEPTOR 1
(Arabidopsis
thaliana) 		3 / 3 ASP A 456
LEU A 410
LEU A 412
 None
 0.77A 1np1B-4pl9A:
undetectable		 1np1B-4pl9A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 4pl9 ETHYLENE RECEPTOR 1
(Arabidopsis
thaliana) 		4 / 4 ILE A 467
PHE A 577
ILE A 464
THR A 574
 None
 1.10A 3ia4A-4pl9A:
undetectable		 3ia4A-4pl9A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4pl9 ETHYLENE RECEPTOR 1
(Arabidopsis
thaliana) 		5 / 10 ILE A 518
ASP A 513
SER A 551
ILE A 562
ILE A 526
 ADP  A 613 ( 4.8A)
CD  A 603 ( 2.1A)
None
None
ADP  A 613 (-4.1A)
 1.24A 3um5A-4pl9A:
undetectable		 3um5A-4pl9A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4pl9 ETHYLENE RECEPTOR 1
(Arabidopsis
thaliana) 		5 / 10 ILE A 518
ASP A 513
SER A 551
ILE A 562
ILE A 526
 ADP  A 613 ( 4.8A)
CD  A 603 ( 2.1A)
None
None
ADP  A 613 (-4.1A)
 1.20A 3um5B-4pl9A:
undetectable		 3um5B-4pl9A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 4pl9 ETHYLENE RECEPTOR 1
(Arabidopsis
thaliana) 		5 / 10 ILE A 467
PHE A 577
LEU A 419
ILE A 464
THR A 574
 None
 0.99A 4km0A-4pl9A:
undetectable		 4km0A-4pl9A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 4pl9 ETHYLENE RECEPTOR 1
(Arabidopsis
thaliana) 		5 / 12 ILE A 467
PHE A 577
LEU A 419
ILE A 464
THR A 574
 None
 0.96A 4km0B-4pl9A:
undetectable		 4km0B-4pl9A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 4pl9 ETHYLENE RECEPTOR 1
(Arabidopsis
thaliana) 		5 / 12 ILE A 467
PHE A 577
LEU A 419
ILE A 464
THR A 574
 None
 1.06A 4km2A-4pl9A:
undetectable		 4km2A-4pl9A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 4pl9 ETHYLENE RECEPTOR 1
(Arabidopsis
thaliana) 		5 / 12 ILE A 467
PHE A 577
LEU A 419
ILE A 464
THR A 574
 None
 1.00A 4km2B-4pl9A:
undetectable		 4km2B-4pl9A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4pl9 ETHYLENE RECEPTOR 1
(Arabidopsis
thaliana) 		5 / 11 ILE A 518
ASP A 513
SER A 551
ILE A 562
ILE A 526
 ADP  A 613 ( 4.8A)
CD  A 603 ( 2.1A)
None
None
ADP  A 613 (-4.1A)
 1.30A 4p68A-4pl9A:
undetectable		 4p68A-4pl9A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 4pl9 ETHYLENE RECEPTOR 1
(Arabidopsis
thaliana) 		5 / 9 PHE A 423
LEU A 443
VAL A 579
VAL A 509
LEU A 581
 None
 1.42A 4wnvA-4pl9A:
1.2		 4wnvA-4pl9A:
17.29