SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4plb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		4 / 5 ARG B 601
ALA B 540
LYS B 502
GLU B 430
 None
 1.00A 1e7cA-4plbB:
undetectable		 1e7cA-4plbB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		5 / 12 LEU B1327
VAL B1308
ALA B1314
ILE B1317
ILE B1286
 None
 0.97A 1epbB-4plbB:
undetectable		 1epbB-4plbB:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		3 / 3 ILE B1230
ASP B1217
PHE B1218
 None
 0.52A 1uwjB-4plbB:
2.5		 1uwjB-4plbB:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		4 / 6 ALA B 614
GLU B 613
ILE B 612
LEU B 608
 None
 0.98A 1xvaA-4plbB:
undetectable
1xvaB-4plbB:
undetectable		 1xvaA-4plbB:
17.75
1xvaB-4plbB:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		5 / 11 ARG B 479
ILE B 478
ILE B 461
GLY B 488
PHE B 523
 None
 1.18A 2azyA-4plbB:
undetectable		 2azyA-4plbB:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		5 / 12 ILE B1289
THR B1290
LEU B1321
ASN B1319
VAL B1281
 None
 1.17A 2vn0A-4plbB:
0.9		 2vn0A-4plbB:
20.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		4 / 5 SER B1084
ARG B 458
GLY B 459
GLU B 477
 None
 0.98A 3k9fA-4plbB:
52.8
3k9fB-4plbB:
52.8
3k9fC-4plbB:
26.3		 3k9fA-4plbB:
32.71
3k9fB-4plbB:
32.71
3k9fC-4plbB:
19.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		4 / 6 SER B1084
ARG B 458
GLY B 459
GLU B 477
 None
 0.98A 3k9fA-4plbB:
52.8
3k9fB-4plbB:
52.8
3k9fD-4plbB:
26.3		 3k9fA-4plbB:
32.71
3k9fB-4plbB:
32.71
3k9fD-4plbB:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		4 / 6 LEU B 604
ALA B 514
THR B 507
LEU B 521
 None
 0.99A 3t3zB-4plbB:
undetectable		 3t3zB-4plbB:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		4 / 4 PRO B 456
LEU B 455
ILE B 431
ARG B 499
 None
 1.12A 4f4dA-4plbB:
2.2		 4f4dA-4plbB:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		4 / 7 TYR B 538
ILE B 503
TYR B 536
HIS B 501
 None
 1.19A 4g5jA-4plbB:
undetectable		 4g5jA-4plbB:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		4 / 8 ASN B1054
ASP B1040
LEU B1160
ILE B1144
 None
 0.99A 4k0bA-4plbB:
undetectable		 4k0bA-4plbB:
22.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		4 / 7 SER B1084
GLY B 436
GLY B 459
GLU B 477
 None
 0.91A 4koeA-4plbB:
53.6
4koeB-4plbB:
53.4
4koeD-4plbB:
28.2		 4koeA-4plbB:
32.71
4koeB-4plbB:
32.71
4koeD-4plbB:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		3 / 3 GLY B1106
GLU B1125
THR B1124
 None
 0.55A 4kouA-4plbB:
undetectable		 4kouA-4plbB:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		4 / 8 ASN B1054
ASP B1040
LEU B1160
ILE B1144
 None
 1.00A 4l7iA-4plbB:
undetectable		 4l7iA-4plbB:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		4 / 5 ILE B1452
LEU B1371
GLU B1454
VAL B1464
 None
 0.99A 4nkxB-4plbB:
undetectable		 4nkxB-4plbB:
21.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		4 / 5 ARG B 458
GLY B 459
GLU B 477
SER B1084
 None
 0.99A 4z3oA-4plbB:
53.9
4z3oB-4plbB:
53.6		 4z3oA-4plbB:
46.88
4z3oB-4plbB:
46.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		4 / 5 ARG B 458
GLY B 459
GLU B 477
SER B1085
 None
 0.87A 4z3oA-4plbB:
53.9
4z3oB-4plbB:
53.6		 4z3oA-4plbB:
46.88
4z3oB-4plbB:
46.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		3 / 3 VAL B1260
THR B1262
ARG B1303
 None
 0.77A 5b2tB-4plbB:
undetectable		 5b2tB-4plbB:
20.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		4 / 6 SER B1084
ARG B 458
GLY B 459
GLU B 477
 None
 1.10A 5btaA-4plbB:
53.3
5btaB-4plbB:
26.7
5btaC-4plbB:
53.3		 5btaA-4plbB:
41.64
5btaB-4plbB:
22.93
5btaC-4plbB:
41.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		4 / 6 SER B1084
ARG B 458
GLY B 459
GLU B 477
 None
 1.07A 5btcA-4plbB:
53.2
5btcC-4plbB:
53.0
5btcD-4plbB:
26.5		 5btcA-4plbB:
41.64
5btcC-4plbB:
41.64
5btcD-4plbB:
22.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		4 / 7 SER B1084
ARG B 458
GLY B 459
GLU B 477
 None
 0.95A 5btfA-4plbB:
52.9
5btfC-4plbB:
53.0
5btfD-4plbB:
26.6		 5btfA-4plbB:
41.64
5btfC-4plbB:
41.64
5btfD-4plbB:
22.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		4 / 5 SER B1084
ARG B 458
GLY B 459
GLU B 477
 None
 1.04A 5btiA-4plbB:
53.2
5btiB-4plbB:
28.2		 5btiA-4plbB:
41.64
5btiB-4plbB:
22.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		4 / 5 SER B1085
ARG B 458
GLY B 459
GLU B 477
 None
 1.21A 5btiA-4plbB:
53.2
5btiB-4plbB:
28.2		 5btiA-4plbB:
41.64
5btiB-4plbB:
22.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		4 / 5 SER B1084
ARG B 458
GLY B 459
GLU B 477
 None
 0.92A 5btiC-4plbB:
53.1
5btiD-4plbB:
26.5		 5btiC-4plbB:
41.64
5btiD-4plbB:
22.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		4 / 6 SER B1084
GLY B 436
ARG B 458
GLY B 459
 None
 0.68A 5cdnR-4plbB:
56.5
5cdnS-4plbB:
30.7		 5cdnR-4plbB:
99.79
5cdnS-4plbB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		4 / 6 SER B1084
GLU B1088
ARG B 458
GLY B 459
 None
 0.78A 5cdpA-4plbB:
58.5
5cdpB-4plbB:
31.5		 5cdpA-4plbB:
100.00
5cdpB-4plbB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		4 / 6 SER B1084
GLU B1088
GLY B 436
GLY B 459
 None
 0.70A 5cdpA-4plbB:
58.5
5cdpB-4plbB:
31.5		 5cdpA-4plbB:
100.00
5cdpB-4plbB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		4 / 5 SER B1085
ARG B 458
GLY B 459
GLU B 477
 None
 0.91A 5cdqA-4plbB:
57.3
5cdqB-4plbB:
30.5
5cdqC-4plbB:
57.2		 5cdqA-4plbB:
99.79
5cdqB-4plbB:
100.00
5cdqC-4plbB:
99.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		4 / 6 SER B1084
ARG B 458
GLY B 459
GLU B 477
 None
 1.01A 5cdqA-4plbB:
57.3
5cdqC-4plbB:
57.2
5cdqD-4plbB:
29.5		 5cdqA-4plbB:
99.79
5cdqC-4plbB:
99.79
5cdqD-4plbB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		4 / 5 SER B1085
ARG B 458
GLY B 459
GLU B 477
 None
 0.90A 5cdqR-4plbB:
57.4
5cdqS-4plbB:
30.5
5cdqT-4plbB:
57.5		 5cdqR-4plbB:
99.79
5cdqS-4plbB:
100.00
5cdqT-4plbB:
99.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		5 / 12 PHE B1022
ALA B1034
GLY B1178
MET B 622
LEU B 519
 None
 1.21A 5ul4A-4plbB:
4.5		 5ul4A-4plbB:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		4 / 6 ILE B1183
ILE B1131
LEU B1103
HIS B1046
 None
 1.06A 5vkqA-4plbB:
4.3
5vkqB-4plbB:
4.3		 5vkqA-4plbB:
17.69
5vkqB-4plbB:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		4 / 7 THR B1486
PHE B1218
HIS B1186
ILE B1213
 None
 1.13A 5vkqA-4plbB:
4.2
5vkqB-4plbB:
4.3		 5vkqA-4plbB:
17.69
5vkqB-4plbB:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		4 / 8 THR B1486
PHE B1218
HIS B1186
ILE B1213
 None
 1.13A 5vkqB-4plbB:
4.3
5vkqC-4plbB:
4.2		 5vkqB-4plbB:
17.69
5vkqC-4plbB:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		4 / 7 THR B1486
PHE B1218
HIS B1186
ILE B1213
 None
 1.11A 5vkqC-4plbB:
4.2
5vkqD-4plbB:
4.3		 5vkqC-4plbB:
17.69
5vkqD-4plbB:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		4 / 6 ILE B1183
ILE B1131
LEU B1103
HIS B1046
 None
 1.04A 5vkqA-4plbB:
4.3
5vkqD-4plbB:
4.3		 5vkqA-4plbB:
17.69
5vkqD-4plbB:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		3 / 3 MET B1113
ASP B1294
ARG B1299
 None
 1.18A 5z6jA-4plbB:
undetectable		 5z6jA-4plbB:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A
(Staphylococcus
aureus) 		4 / 4 ARG B1137
GLU B1134
GLU B1475
ARG B1479
 None
 1.32A 6fk2A-4plbB:
undetectable		 6fk2A-4plbB:
11.61