SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4plf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 4plf LACTATE
DEHYDROGENASE
(Apicomplexa) 		6 / 9 GLY A  15
ASP A  39
TYR A  71
ALA A  84
ILE A 109
GLU A 112
 NAI  A 401 ( 3.6A)
NAI  A 401 (-2.2A)
None
NAI  A 401 (-3.4A)
NAI  A 401 (-3.7A)
NAI  A 401 ( 3.5A)
 0.42A 1cetA-4plfA:
45.5		 1cetA-4plfA:
61.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 4plf LACTATE
DEHYDROGENASE
(Apicomplexa) 		4 / 7 GLY A 230
ARG A  99
ILE A 232
VAL A 233
 None
PYR  A 402 (-3.8A)
None
None
 0.98A 1rxcC-4plfA:
undetectable		 1rxcC-4plfA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4plf LACTATE
DEHYDROGENASE
(Apicomplexa) 		5 / 10 ALA A 249
ILE A  81
GLY A 153
HIS A 186
ASP A 134
 None
None
None
NAI  A 401 ( 3.4A)
None
 1.40A 2b17A-4plfA:
undetectable		 2b17A-4plfA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4plf LACTATE
DEHYDROGENASE
(Apicomplexa) 		5 / 11 GLN A  46
PRO A  45
ASP A  39
VAL A 113
ILE A 109
 None
None
NAI  A 401 (-2.2A)
None
NAI  A 401 (-3.7A)
 1.20A 3n23A-4plfA:
undetectable		 3n23A-4plfA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4plf LACTATE
DEHYDROGENASE
(Apicomplexa) 		4 / 7 THR A 225
VAL A 281
SER A 160
ASP A 309
 None
 1.21A 4iarA-4plfA:
undetectable		 4iarA-4plfA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4plf LACTATE
DEHYDROGENASE
(Apicomplexa) 		4 / 8 GLY A  85
GLY A  17
ILE A  19
LEU A  13
 NAI  A 401 (-4.0A)
NAI  A 401 (-3.3A)
NAI  A 401 (-3.7A)
None
 0.76A 4mwzB-4plfA:
undetectable		 4mwzB-4plfA:
23.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 4plf LACTATE
DEHYDROGENASE
(Apicomplexa) 		5 / 9 ASP A  39
VAL A  40
TYR A  71
ALA A  84
ILE A 109
 NAI  A 401 (-2.2A)
NAI  A 401 (-4.5A)
None
NAI  A 401 (-3.4A)
NAI  A 401 (-3.7A)
 0.91A 4oknB-4plfA:
38.7		 4oknB-4plfA:
32.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4plf LACTATE
DEHYDROGENASE
(Apicomplexa) 		5 / 12 PHE A 105
GLY A  85
ALA A  84
ASN A 131
PRO A 104
 None
NAI  A 401 (-4.0A)
NAI  A 401 (-3.4A)
NAI  A 401 ( 3.2A)
None
 1.11A 4rtpA-4plfA:
3.6		 4rtpA-4plfA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 4plf LACTATE
DEHYDROGENASE
(Apicomplexa) 		3 / 3 GLY A 153
CYH A 266
CYH A 268
 None
 0.96A 5inzB-4plfA:
undetectable		 5inzB-4plfA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4plf LACTATE
DEHYDROGENASE
(Apicomplexa) 		4 / 9 ILE A 213
VAL A 197
THR A 194
ASP A 219
 None
 0.93A 5lg3I-4plfA:
undetectable		 5lg3I-4plfA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4plf LACTATE
DEHYDROGENASE
(Apicomplexa) 		4 / 5 TYR A 274
GLN A 273
GLY A 156
ILE A 183
 None
 1.45A 6debB-4plfA:
4.0		 6debB-4plfA:
13.72