SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4plh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 4plh MALATE DEHYDROGENASE
(Apicomplexa) 		6 / 9 GLY A  11
ASP A  35
ILE A  36
TYR A  67
ALA A  80
ILE A 100
 NAI  A 403 ( 4.3A)
NAI  A 403 (-2.8A)
NAI  A 403 (-3.8A)
None
NAI  A 403 (-3.4A)
NAI  A 403 (-3.7A)
 0.58A 1cetA-4plhA:
46.9		 1cetA-4plhA:
55.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 4plh MALATE DEHYDROGENASE
(Apicomplexa) 		6 / 12 ALA A 259
GLY A 176
GLY A 175
SER A 302
LEU A 261
LEU A 291
 None
 1.42A 1ya4A-4plhA:
undetectable		 1ya4A-4plhA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4plh MALATE DEHYDROGENASE
(Apicomplexa) 		5 / 10 ALA A 240
ILE A  77
GLY A 144
HIS A 177
ASP A 125
 None
None
None
NAI  A 403 ( 3.7A)
None
 1.45A 2b17A-4plhA:
undetectable		 2b17A-4plhA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 4plh MALATE DEHYDROGENASE
(Apicomplexa) 		5 / 11 ILE A 241
ASN A 122
ILE A 118
VAL A  31
LEU A   9
 None
OXM  A 401 ( 3.3A)
None
None
None
 1.22A 3a51A-4plhA:
undetectable		 3a51A-4plhA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 4plh MALATE DEHYDROGENASE
(Apicomplexa) 		5 / 12 ILE A 241
ASN A 122
ILE A 118
VAL A  31
LEU A   9
 None
OXM  A 401 ( 3.3A)
None
None
None
 1.23A 3a51D-4plhA:
undetectable		 3a51D-4plhA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 4plh MALATE DEHYDROGENASE
(Apicomplexa) 		5 / 12 ILE A 241
ASN A 122
ILE A 118
VAL A  31
LEU A   9
 None
OXM  A 401 ( 3.3A)
None
None
None
 1.19A 3a51E-4plhA:
undetectable		 3a51E-4plhA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4plh MALATE DEHYDROGENASE
(Apicomplexa) 		5 / 11 GLN A  42
PRO A  41
ASP A  35
VAL A 104
ILE A 100
 None
None
NAI  A 403 (-2.8A)
None
NAI  A 403 (-3.7A)
 1.17A 3n23A-4plhA:
undetectable		 3n23A-4plhA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4plh MALATE DEHYDROGENASE
(Apicomplexa) 		4 / 7 THR A 216
VAL A 272
SER A 151
ASP A 300
 None
 1.25A 4iarA-4plhA:
undetectable		 4iarA-4plhA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4plh MALATE DEHYDROGENASE
(Apicomplexa) 		4 / 8 GLY A  81
GLY A  13
ILE A  15
LEU A   9
 NAI  A 403 (-4.3A)
NA  A 402 ( 3.3A)
NAI  A 403 ( 3.8A)
None
 0.70A 4mwzB-4plhA:
undetectable		 4mwzB-4plhA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4plh MALATE DEHYDROGENASE
(Apicomplexa) 		5 / 12 GLY A 175
GLY A 176
GLY A 147
ALA A 146
ILE A 254
 None
None
None
NAI  A 403 ( 4.5A)
None
 0.89A 4rtmA-4plhA:
3.5		 4rtmA-4plhA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 4plh MALATE DEHYDROGENASE
(Apicomplexa) 		4 / 7 GLY A 273
MET A 172
ALA A 259
ILE A 286
 None
 0.84A 4txnA-4plhA:
2.6		 4txnA-4plhA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 4plh MALATE DEHYDROGENASE
(Apicomplexa) 		4 / 7 GLY A 273
MET A 172
ALA A 259
ILE A 286
 None
 0.86A 4txnB-4plhA:
2.6		 4txnB-4plhA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 4plh MALATE DEHYDROGENASE
(Apicomplexa) 		4 / 7 GLY A 273
MET A 172
ALA A 259
ILE A 286
 None
 0.83A 4txnC-4plhA:
2.6		 4txnC-4plhA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 4plh MALATE DEHYDROGENASE
(Apicomplexa) 		4 / 7 GLY A 273
MET A 172
ALA A 259
ILE A 286
 None
 0.85A 4txnD-4plhA:
2.5		 4txnD-4plhA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4plh MALATE DEHYDROGENASE
(Apicomplexa) 		4 / 5 TYR A 265
GLN A 264
GLY A 147
ILE A 174
 None
 1.46A 6debB-4plhA:
4.0		 6debB-4plhA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 4plh MALATE DEHYDROGENASE
(Apicomplexa) 		3 / 3 ASP A  30
SER A  49
SER A  52
 None
 0.60A 6mxtA-4plhA:
undetectable		 6mxtA-4plhA:
22.04